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64 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Hepatomegaly

  • Glycogen Storage Disease Type 1

    The syndrome results in hepatomegaly secondary to glycogen accumulation, glucose and galactose intolerance, fasting hypoglycaemia, a characteristic proximal tubular nephropathy[en.wikipedia.org] Phk activity in erythrocytes was markedly decreased (12% residual activity) while the parents' erythrocyte Phk activities were in the heterozygote range (mother: 56%; father[academic.oup.com] Abstract A male child presented at 5 months of age with vomiting, diarrhoea, hypoglycaemia and hepatomegaly.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    […] hepatitis B virus, drug usage or cholestatic syndrome and in around 40% of cases its etiology will be defined as autoimmune. 22 One patient from the present sample developed hepatomegaly[scielo.br] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] H1N1 influenza–associated AIHA in children may respond to treatment with oseltamivir and intravenous immunoglobulin. [6] Fetal splenomegaly and associated hepatomegaly could[emedicine.medscape.com]

  • Hereditary Spherocytosis

    Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[ncbi.nlm.nih.gov] Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] Hepatomegaly may be present. Cholelithiasis (pigment stones) is common and may be the presenting symptom.[merckmanuals.com]

  • Congenital Hemolytic Anemia

    […] in the newborn period 516 Hepatomegaly in children General overview 517 Hepatomegaly with portal hypertention and obstructive jaundice 519 Liver calcifications in the pediatric[books.google.ro] Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org]

  • Fetal Erythroblastosis

    Also, the newborn will be anemic and pale and present splenomegaly and hepatomegaly, caused by extramedullary hematopoiesis. Portal hypertension has the same cause.[symptoma.com] The phenotype of severe nonspherocytic hemolytic anemia, jaundice, hepatosplenomegaly, and marked erythroblastosis is more severe than that present in congenital dyserythropoietic[readbyqxmd.com] […] haemolyticus neonatorum (fetal erythroblastosis) with the following symptoms: anemia (due to the hemolysis) splenomegaly (location of the macrophages that destroy the erythrocytes) hepatomegaly[embryology.ch]

  • Pyruvate Kinase Deficiency

    He rapidly developed important splenomegaly and hepatomegaly, associated with hepatic failure marked by ascites, coagulopathy, hypoalbuminemia, and severe cholestasis.[pediatrics.aappublications.org] decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org]

  • Congenital Dyserythropoietic Anemia

    CDA I patients have a moderate macrocytic anemia with frequent splenomegaly and occasional hepatomegaly.[orpha.net] We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com]

  • Toxic Hemolytic Anemia

    […] long term therapeutic treatment have shown symptoms of hypersensitivity hepatitis with nausea, vomiting, epigastric or right upper quadrant pain, myalgias, fever, jaundice, hepatomegaly[path.upmc.edu] […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] […] particularly focus on general appearance (signs of fatigue, paleness), jaundice (yellow skin and eyes), paleness of the nail beds, enlarged spleen ( splenomegaly ) or liver (hepatomegaly[emedicinehealth.com]

  • Traumatic Hemolytic Anemia

    […] symptoms of anemia (paleness, fatigue, dyspnea, palpitations), findings such as familial or personal history of jaundice, exposure to toxics, leg ulcers, lymphadenopathies, hepatomegaly[ncbi.nlm.nih.gov] […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] Examination New onset of pallor and anemia Jaundice Gallstones Splenomegaly /- hepatomegaly INVESTIGATIONS Confirm haemolysis Increased absolute reticulocyte count LDH (elevation[lifeinthefastlane.com]

  • Acquired Toxic Hemolytic Anemia

    Examination New onset of pallor and anemia Jaundice Gallstones Splenomegaly /- hepatomegaly INVESTIGATIONS Confirm haemolysis Increased absolute reticulocyte count LDH (elevation[lifeinthefastlane.com] Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

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