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55 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Hyperbilirubinemia

  • Hereditary Spherocytosis

    Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] In the case of severe hyperbilirubinemia out of proportion with hemolysis, other causes of hyperbilirubinemia must be considered.[ncbi.nlm.nih.gov] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    AIHAs can result in the classic set of symptoms associated with anemia (see page) as well as an unconjugated hyperbilirubinemia and in some cases jaundice if hemolysis is[pathwaymedicine.org] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] […] findings are based on the severity of the patient's hemolysis and may include varying degrees of anemia, reticulocytosis, elevated lactate dehydrogenase (LDH), indirect hyperbilirubinemia[clinicaladvisor.com]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] We report an infant with neonatal hyperbilirubinemia due to pyruvate kinase deficiency.[ncbi.nlm.nih.gov]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] Long-term phenobarbital treatment (2 mg/kg body weight/day) permanently reduced hyperbilirubinemia in a patient with congenital non-spherocytic hemolytic anemia due to erythrocyte[ncbi.nlm.nih.gov]

  • Fetal Erythroblastosis

    The phenotype of severe nonspherocytic hemolytic anemia, jaundice, hepatosplenomegaly, and marked erythroblastosis is more severe than that present in congenital dyserythropoietic[readbyqxmd.com] Risk Zone as a Predictor of Hyperbilirubinemia 39 TABLE 5.[pediatrics.aappublications.org] Fetal and neonatal edition, 2018 May 25 [PubMed] Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants., Amin SB,Wang H,, The Journal[knowledge.statpearls.com]

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com] These results confirm the authors' previous findings and add neonatal manifestations not previously described, particularly hyperbilirubinemia and thrombocytopenia.[ncbi.nlm.nih.gov]

  • Traumatic Hemolytic Anemia

    […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] The destruction of RBCs in HAs is characterized by an increased breakdown of hemoglobin which results in unconjugated hyperbilirubinemia clinically evidenced by jaundice,[ncbi.nlm.nih.gov] Unconjugated hyperbilirubinemia is present along with an elevated LDH. With intravascular hemolysis, hemoglobin spills from the destroyed red cells into the plasma.[thebigl.co]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    If t he fluidity of the cell interior or the surplus of cell surface is reduced, the “conformation instability” of the erythrocyte will decrease.[content.iospress.com] .: Glucose phosphate isomerase deficiency with congenital nonspherocytic hemolytic anemia: A new variant (type Nordhorn). II.[link.springer.com] […] and readmitted to hospital owing to hyperbilirubinemia over five years.[ncbi.nlm.nih.gov]

  • Toxic Hemolytic Anemia

    […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] Unconjugated (indirect) hyperbilirubinemia and jaundice occur when the conversion of hemoglobin to bilirubin exceeds the liver’s capacity to conjugate and excrete bilirubin[merckmanuals.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

  • Acquired Toxic Hemolytic Anemia

    Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] Unconjugated (indirect) hyperbilirubinemia and jaundice occur when the conversion of hemoglobin to bilirubin exceeds the liver’s capacity to conjugate and excrete bilirubin[msdmanuals.com]

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