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35 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Lactate Dehydrogenase Increased

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[clinicaladvisor.com] Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] Other biochemical changes of hemolysis also are also present, including: increased lactate dehydrogenase (LDH) increased unconjugated bilirubin decreased serum haptoglobin[steadyhealth.com]

  • Autoimmune Hemolytic Anemia

    Unconjugated bilirubin is usually, but not always, elevated and urine urobilinogen is increased. Lactate dehydrogenase is usually elevated into the thousands.[clinlabnavigator.com] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info]

  • Glycogen Storage Disease Type 1

    The incresased levels of pyruvate lead to increased lactate produciton via lactate dehydrogenase (LDH) and alanine via alanine transaminase (ALT).[themedicalbiochemistrypage.org] Phk activity in erythrocytes was markedly decreased (12% residual activity) while the parents' erythrocyte Phk activities were in the heterozygote range (mother: 56%; father[academic.oup.com] Chronic hepatitis Albuminuria Distal renal tubular acidosis Hepatocellular adenoma Hypocitraturia Cataract Hyperreflexia Gait disturbance Full cheeks Carcinoma Elevated erythrocyte[mendelian.co]

  • Toxic Hemolytic Anemia

    DISCUSSION The initial symptoms and laboratory findings of hemolytic anemia, depressed hemoglobin and haptoglobin concentrations, increased lactate dehydrogenase, increased[clinchem.aaccjnls.org] […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] Hemolysis is associated with a release of RBC lactate dehydrogenase (LDH).[emedicine.medscape.com]

  • Acquired Toxic Hemolytic Anemia

    Breakdown of RBCs releases lactate dehydrogenase and potassium, leading to elevation of both in serum.[accessmedicine.mhmedical.com] Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

  • Congenital Hemolytic Anemia

    Diagnosis is based on several laboratory parameters 1 : reticulocytosis increased unconjugated bilirubin increased lactate dehydrogenase decreased haptoglobin Pathology With[radiopaedia.org] Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org]

  • Anemia due to Glutathione Metabolism Disorder

    Total and unconjugated bilirubin : levels are increased due to increased RBC destruction Serum lactate dehydrogenase (LDH) level : increased Serum haptoglobin level : decreased[medcaretips.com] Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[annals.org] D58.9 ICD-10-CM Diagnosis Code D58.9 Hereditary hemolytic anemia, unspecified 2016 2017 2018 2019 Billable/Specific Code nonspherocytic congenital or hereditary NEC D55.8[icd10data.com]

  • Pyruvate Kinase Deficiency

    PAGE BREAK Patients who achieved at least 1 g/dL increase in hemoglobin also demonstrated an increase in haptoglobin and decrease in lactate dehydrogenase in the first weeks[healio.com] decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org]

  • Traumatic Hemolytic Anemia

    Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info] […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] increased lactate dehydrogenase (cellular destruction), and reticulocytosis, which is a normal compensatory response of the bone marrow to the RBC loss.[ncbi.nlm.nih.gov]

  • Red Blood Cell Disorder

    Additional causes include a decreased rate of erythrocyte production and increased destruction of RBCs. Table 40-1 lists common causes of various types of anemia.[intranet.tdmu.edu.ua] Summary Epidemiology PK deficiency is the most frequent cause of congenital nonspherocytic hemolytic anemia with a prevalence estimated at 1/20,000 in the general white population[orpha.net] , as in patients with congenital nonspherocytic hemolytic anemia due to glucose-6-phosphate dehydrogenase or pyruvate kinase deficiency.[mayomedicallaboratories.com]

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