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27 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Mean Corpuscular Volume Increased

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Reticulocyte counts are usually elevated, and an increased MCV (mean corpuscular volume) (greater than 100 fl) can be seen, due to the larger size of reticulocytes in comparison[cancertherapyadvisor.com] At 2 to 4 weeks after diagnosis, acute anemia, characterized by an elevated mean corpuscular volume (MCV), reticulocytosis, an undetectable haptoglobin level, and an increased[nejm.org]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] Mean corpuscular hemoglobin concentration (MCHC) is increased (35-38%) in approximately 50% of patients.[clinicaladvisor.com] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org]

  • Hereditary Spherocytosis

    Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] […] count 19%, mean sphered corpuscular volume 71.66 fl, total bilirubin 57.60 μmol/l, and blood smears showed increased spherocytosis.[ncbi.nlm.nih.gov] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[ncbi.nlm.nih.gov]

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com] The decrease of bilirubin and normal values of haptoglobin might be the concequence of diminished destruction of erythrocytes and their precursors.[ncbi.nlm.nih.gov]

  • Refractory Megaloblastic Anemia

    Lack of CTP, TMP, and UTP leads to a decreased nucleic acid synthesis and decreased erythrocyte formation resulting in Megaloblastic anemia.[usmle.biochemistryformedics.com] In a recent study, 7 percent of patients had a mean corpuscular volume greater than 96 fL, and 1.7 percent had a mean corpuscular volume greater than 100 fL. 2 With the advent[aafp.org] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed , Scholar , Google , WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed ,[lsd-project.jp]

  • Fetal Erythroblastosis

    The phenotype of severe nonspherocytic hemolytic anemia, jaundice, hepatosplenomegaly, and marked erythroblastosis is more severe than that present in congenital dyserythropoietic[readbyqxmd.com]

  • Toxic Hemolytic Anemia

    […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] VPA is also shown to affect the mean corpuscular volume (MCV) of erythrocytes.[bmcnephrol.biomedcentral.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

  • Traumatic Hemolytic Anemia

    […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org] Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[aafp.org]

  • Acquired Toxic Hemolytic Anemia

    Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

  • Hereditary Sideroblastic Anemia

    […] and gama-interferon inhibit red cell production Shortened erythrocyte survival Autoimmune diseases may also cause antibody-mediated destruction CBC: Mild anemia (Hgb 9-11[quizlet.com] The mean corpuscular volume (MCV) is normal or increased, but can be low. High serum iron and transferrin saturation also occur.[patient.info] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp]

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