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25 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Osmotic Fragility Increased

  • Hereditary Spherocytosis

    Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] fragility: increased; basis for diagnostic testing Diagrams / tables Images hosted on other servers: Scatter diagram of CBC Treatment Splenectomy (prolongs survival of red[pathologyoutlines.com] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[ncbi.nlm.nih.gov]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] Osmotic fragility of fresh blood was increased, and postsplenectomy blood showed a fraction of extremely fragile cells.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] In patients with Evans syndrome, the mechanism of destruction of erythrocytes is thought to be similar to AIHA.[cancertherapyadvisor.com] Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[aafp.org]

  • Glycogen Storage Disease Type 1

    Phk activity in erythrocytes was markedly decreased (12% residual activity) while the parents' erythrocyte Phk activities were in the heterozygote range (mother: 56%; father[academic.oup.com] Chronic hepatitis Albuminuria Distal renal tubular acidosis Hepatocellular adenoma Hypocitraturia Cataract Hyperreflexia Gait disturbance Full cheeks Carcinoma Elevated erythrocyte[mendelian.co] […] hypoplastic anemia Hyperkalemia Inflammation of the large intestine Intestinal obstruction Episodic fever Amyloidosis Antinuclear antibody positivity Acute hepatic failure Decreased[mendelian.co]

  • Fetal Erythroblastosis

    The phenotype of severe nonspherocytic hemolytic anemia, jaundice, hepatosplenomegaly, and marked erythroblastosis is more severe than that present in congenital dyserythropoietic[readbyqxmd.com] fragility of the red cells may be greatly increased. [3], [18] As all other cell lines were in normal range with a low reticulocyte count since birth indicating a possible[doi.org] […] due to anti-M shows two features that resemble ABO hemolytic disease rather than Rh hemolytic disease: First, the DAT is only weakly positive or negative and second, the osmotic[doi.org]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] Partial PK deficiency was associated with decreased red cell ATP content and markedly increased osmotic fragility.[ncbi.nlm.nih.gov]

  • Anemia due to Glutathione Metabolism Disorder

    Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[annals.org] D58.9 ICD-10-CM Diagnosis Code D58.9 Hereditary hemolytic anemia, unspecified 2016 2017 2018 2019 Billable/Specific Code nonspherocytic congenital or hereditary NEC D55.8[icd10data.com] Usually the anemia is episodic, but some of the unusual variants of G-6-PD may cause nonspherocytic congenital hemolytic disease (see below).[g6pd.org]

  • Hereditary Elliptocytosis

    70% of control values, and total erythrocyte spectrin content in one proband was also decreased on SDS-PAGE.[ncbi.nlm.nih.gov] MCHC more than 36% C. increased osmotic fragility D. all of the above D. all of the above spherocytes on the peripheral smear MCHC more than 36% increased osmotic fragility[quizlet.com] , as in patients with congenital nonspherocytic hemolytic anemia due to glucose-6-phosphate dehydrogenase or pyruvate kinase deficiency.[mayomedicallaboratories.com]

  • Acquired Toxic Hemolytic Anemia

    Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] […] incubated osmotic fragility Negative DAT Increased MCHC 36% due to relative cellular dehydration Increased bilirubin, LDH (may be subtle) 18 (Incubated) Osmotic Fragility[slideplayer.com]

  • Congenital Hypoplastic Anemia

    The second of these cases provided an unusual opportunity to study human erythrocyte precursor dynamics.[ncbi.nlm.nih.gov] 1) Hb F - often increased 2) EPO - increased 3) Serum iron - increased 4) %TS - increased 5) Ferritin normal 6) In Fanconi's anemia Increased osmotic fragility Increased instability[quizlet.com] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp]

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