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50 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Reticulocytes Increased

  • Hereditary Spherocytosis

    Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases.[medical-labs.net] Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive.[ncbi.nlm.nih.gov]

  • Congenital Hemolytic Anemia

    After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination[ncbi.nlm.nih.gov] Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org]

  • Pyruvate Kinase Deficiency

    Char10C mice also display a reduction in anemia phenotypes associated with the PklrG338D mutation including decreased splenomegaly, decreased circulating reticulocytes, increased[ncbi.nlm.nih.gov] decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org]

  • Glycogen Storage Disease Type 1

    Phk activity in erythrocytes was markedly decreased (12% residual activity) while the parents' erythrocyte Phk activities were in the heterozygote range (mother: 56%; father[academic.oup.com] Chronic hepatitis Albuminuria Distal renal tubular acidosis Hepatocellular adenoma Hypocitraturia Cataract Hyperreflexia Gait disturbance Full cheeks Carcinoma Elevated erythrocyte[mendelian.co] […] hypoplastic anemia Hyperkalemia Inflammation of the large intestine Intestinal obstruction Episodic fever Amyloidosis Antinuclear antibody positivity Acute hepatic failure Decreased[mendelian.co]

  • Toxic Hemolytic Anemia

    Increased reticulocytes lead to increased MCV but not like megaloblastic anemias. Serum bilirubin is raised. Urine urobilinogen is positive.[labpedia.net] […] and the inability of bone marrow to compensate for the decreased life span.[diagnose-me.com] Hemolysis, in these patients, usually occurs 24 to 48 hours after exposure and is characterized by diminished hemoglobin and hematocrit, increase in reticulocyte count, increase[path.upmc.edu]

  • Congenital Dyserythropoietic Anemia

    On this treatment, hemoglobin and reticulocytes increased and transfusions became unnecessary.[ncbi.nlm.nih.gov] We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com]

  • Acquired Toxic Hemolytic Anemia

    The complete blood count (CBC) serves as the diagnostic cornerstone, providing the anemic level hemoglobin and hematocrit and the increased reticulocyte count indicative of[accessmedicine.mhmedical.com] Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

  • Hypersplenism

    Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors[5minuteconsult.com] As a disorder, hypersplenism typically involves a distended spleen (splenomegaly), decreased levels of leukocytes, erythrocytes and platelets, shorter platelet and erythrocyte[symptoma.com] […] abscess (rare) Splenectomy sometimes indicated Elliptocytosis with hemolysis Nonspherocytic congenital hemolytic anemias Hodgkin’s disease (for staging) Idiopathic myelofibrosis[for-surgeons.com]

  • Fetal Erythroblastosis

    He or she will be anemic, with increased reticulocyte count, anisocytosis, spherocytosis, and young (nucleated, immature) red blood cells released into circulation.[symptoma.com] The phenotype of severe nonspherocytic hemolytic anemia, jaundice, hepatosplenomegaly, and marked erythroblastosis is more severe than that present in congenital dyserythropoietic[readbyqxmd.com] Peripheral blood morphology shows increased reticulocytes. Erythroblasts (also known as nucleated red blood cells) occur in moderate and severe disease.[moondragon.org]

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