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65 Possible Causes for Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased, Splenomegaly

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[] Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[]

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[] The diagnosis of HLH after SOT is especially difficult, as several of the diagnostic criteria, including fever, splenomegaly, and cytopenias, are nonspecific and can be seen[]

  • Pyruvate Kinase Deficiency

    She is doing well with mild splenomegaly.[] decreased erythrocyte pyruvate kinase (PK) activity.[] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[]

  • Congenital Hemolytic Anemia

    Children with massive splenomegaly had similar outcomes compared with children without massive splenomegaly.[] Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[]

  • Traumatic Hemolytic Anemia

    Splenomegaly and Hypersplenism (link accessible from “Related Topics” below) On a microscopic level the hematologist can see red blood cell fragments with odd shapes in a[] […] and the inability of bone marrow to compensate for the decreased life span.[] Physical findings include orthostatic hypotension, tachycardia, jaundice, icteris, and splenomegaly.[]

  • Congenital Dyserythropoietic Anemia

    CDA I patients have a moderate macrocytic anemia with frequent splenomegaly and occasional hepatomegaly.[] We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[]

  • Glycogen Storage Disease Type 1

    Ultrasound revealed a small, cirrhotic liver, portal vein thrombosis, and splenomegaly.[] Phk activity in erythrocytes was markedly decreased (12% residual activity) while the parents' erythrocyte Phk activities were in the heterozygote range (mother: 56%; father[] Hepatomegaly, usually without enlargement of the spleen (splenomegaly), begins to develop in fetal life and is usually noticeable in the first few months of life.[]

  • Hypersplenism

    RESULTS: While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[] As a disorder, hypersplenism typically involves a distended spleen (splenomegaly), decreased levels of leukocytes, erythrocytes and platelets, shorter platelet and erythrocyte[] […] abscess (rare) Splenectomy sometimes indicated Elliptocytosis with hemolysis Nonspherocytic congenital hemolytic anemias Hodgkin’s disease (for staging) Idiopathic myelofibrosis[]

  • Toxic Hemolytic Anemia

    Splenomegaly. Venous thrombosis occasionally. 15. Severe form. There is severe hemolysis associated with hemoglobinemia,hemoglobinuria and shock.[] […] and the inability of bone marrow to compensate for the decreased life span.[] Hemolytic anemia in splenomegaly. Paroxysmal nocturnal hemoglobinuria. Anemia due to acquired RBCs membrane abnormality. Secondary to liver and kidneys diseases.[]

  • Acquired Toxic Hemolytic Anemia

    Pediatricians frequently fail to order a reticulocyte count or detect splenomegaly on physical examination before referring a patient with anemia.[] Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[]

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