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20 Possible Causes for Congophilic Inclusions, Vacuolization

  • Inclusion Body Myositis

    The coexistence of ring fibres, rimmed vacuoles and inclusion-body myositis-type inclusions in a child with congenital myopathy has not been previously reported.[ncbi.nlm.nih.gov] […] aspects of the IBM phenotype: vacuolation, congophilic inclusions, and clusters of immunocolocalizing amyloid beta-peptide (Abeta) and TTR accumulations.[ncbi.nlm.nih.gov] Abstract OBJECTIVE: Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature.[ncbi.nlm.nih.gov]

  • Distal Myopathy

    Extremely large variations in muscle fibre diameter (the size of some fibres exceeding 200-250 microns), rimmed vacuoles, necrotic fibres invaded by macrophages, atrophic[ncbi.nlm.nih.gov] Muscle biopsy showed rare rimmed vacuoles, minicore-like structures and congophilic inclusions.[ncbi.nlm.nih.gov] Congophilic Variably contain: β amyloid, desmin, SMI-31 binding Cytoplasmic bodies (95%) Stain for F-actin (Phalloidin) "Necklace" pattern in muscle fibers 38 Muscle fiber[neuromuscular.wustl.edu]

  • Inclusion Body Myopathy

    The most significant muscle pathology is the presence of rimmed vacuoles, which appear to play a major role in muscle atrophy and weakness.[ncbi.nlm.nih.gov] Muscle biopsies showed necrotic, regenerating, and rimmed vacuolated fibers as well as congophilic inclusions in some of the fibers.[ncbi.nlm.nih.gov] The vacuoles either appear empty or contain granular or amorphous basophilic inclusions or congophilic masses.[ncbi.nlm.nih.gov]

  • Distal Myopathy Type 3

    Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] Congophilic Variably contain: β amyloid, desmin, SMI-31 binding Cytoplasmic bodies (95%) Stain for F-actin (Phalloidin) "Necklace" pattern in muscle fibers 38 Muscle fiber[neuromuscular.wustl.edu] Yonsei Medical Journal. 2013; 54(3): 578-582 [Pubmed] 7 Distal myopathy with rimmed vacuoles and inflammation: A genetically proven case Kannan, M.A. and Challa, S. and Urtizberea[neurologyindia.com]

  • Tibial Muscular Dystrophy

    The main target of the disease, the tibial anterior muscle, shows progressive dystrophic changes with rimmed vacuoles at the early stages and complete replacement pathology[ncbi.nlm.nih.gov] Congophilic Variably contain: β amyloid, desmin, SMI-31 binding Cytoplasmic bodies (95%) Stain for F-actin (Phalloidin) "Necklace" pattern in muscle fibers 38 Muscle fiber[neuromuscular.wustl.edu] Histopathological changes in muscle are compatible with muscular dystrophy, with the exception that rimmed vacuoles are a rather common finding.[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] inclusions: Few Myofibfillar stains: Rare desmin & αB-crystallin aggregates Ultrastructure: Cytoplasmic inclusions, 15–21 nm filaments Serum CK: Mildly high; 300 to 400 EMG[neuromuscular.wustl.edu] Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[ncbi.nlm.nih.gov]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    : Few Distal dystrophy Rimmed vacuoles Dominant DNAJB6 7q36 10 to 50 years Legs: Distal Normal, or Slight Myopathic Vacuoles HIBM1 Dominant Desmin 2q35 25 to 40 years Legs[neuromuscular.wustl.edu] ; DMRV; Nonaka myopathy; Rimmed vacuole myopathy; Quadriceps Sparing Myopathy; GNE myopathy "OMIM Entry # 605820 - Nonaka Myopathy".[en.wikipedia.org] Myopathy Panel analyzes up to five genes associated with inclusion body myopathy ( IBM ), which encompasses a group of myopathies that present with characteristic rimmed vacuoles[invitae.com]

  • Vacuolar Neuromyopathy

    […] muscular dystrophy 32 HP:0003560 9 centrally nucleated skeletal muscle fibers 32 HP:0003687 10 scapular winging 32 HP:0003691 11 neck flexor weakness 32 HP:0003722 12 rimmed vacuoles[malacards.org] Muscle biopsy showed vacuolar changes and congophilic inclusions, and molecular analysis revealed a pathogenic mutation in the DNAJB6 gene.[mayoclinic.pure.elsevier.com] Congophilic Variably contain: β amyloid, desmin, SMI-31 binding Cytoplasmic bodies (95%) Stain for F-actin (Phalloidin) "Necklace" pattern in muscle fibers 38 Muscle fiber[neuromuscular.wustl.edu]

  • Adult Polyglucosan Body Disease

    […] recurrent episodes after exercise Treatment: Low carbohydrate diet; Regular exercise Skeletal muscle Abnormal glycogen accumulation: Coarse granular, Amylase-resistant, Cytoplasmic[neuromuscular.wustl.edu] They were non argyrophilic and non congophilic. Ultrastructurally, the inclusion bodies consisted of aggregates of filamentous materials showing partial periodicity.[onlinelibrary.wiley.com] Normal intratecal synthesis. 14 Loc Lidia, 32 y NCVs: severely decreased for a severe sensory-motor myelinic polineuropathy Mielobiopsy: vacuolated cells ASA: 12 mmoles/h[docplayer.it]

  • Semantic Dementia

    […] in gray matter -- neuronal loss, gliosis, vacuolation of neuropil -- "spongiform" changes On autopsy of pt with prion dz, what does brain look like?[quizlet.com] Fig. 2 Photomicrographs showing diagnostic features. ( A ) (Case 18: haematoxylin and eosin) Congophilic angiopathy and cortical ischaemia. ( B ) (Case 18: ubiquitin immunohistochemistry[doi.org] ) Ubiquitin-positive inclusion in the inferior olivary nucleus in Alzheimer's disease. ( C ) (Case 16: tau immunohistochemistry) Pick bodies in the granule cells of the dentate[doi.org]

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