Congophilic-staining: Causes & Reasons

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Possible Causes for congophilic staining

Amyloidosis

Systemic light chain amyloidosis (AL) is a life-threatening disease caused by aggregation and deposition of monoclonal immunoglobulin light chains (LC) in target organs. Severity of heart involvement is the most important factor determining prognosis. Here, we report the 4.0 Å resolution cryo-electron microscopy map[…] [ncbi.nlm.nih.gov]

ADan Amyloidosis

In particular, they are congophilic (stained with Congo red), they fluorescent following staining with thioflavin S and they are composed of fibrils which are visible under [neurologia.com.pl]

Glomerulonephritis

Three glomeruli (including the two with crescents) showed small segmental mesangial accumulations of Congophilic material that stained immunohistochemically for amyloid A [academic.oup.com]

Cerebral Neoplasm

F, Congophilic deposits have apple green birefringence (Congo red stain and polarized light, original magnification 400). [archivesofpathology.org]

Ampulla of Vater Obstruction Syndrome

Ampullary biopsy with kappa light chain immunohistochemistry staining revealing infiltration with a congophilic material of apple-green birefringence consistent with amyloid [acgcasereports.gi.org]

Plummer-Vinson Syndrome

(D) Positive result for serum amyloid A protein immunohistochemistry staining in the blood vessel wall (immunoperoxidase, 100). [synapse.koreamed.org]

(C) The acellular material in the vessel wall showing congophilic and apple-green birefringence on polarization (Congo red, 200). [synapse.koreamed.org]

Multiple Myeloma

Microscopic examination of the gastric mass revealed amorphous deposits that were congophilic in nature and stained positive with Alcian blue. [ncbi.nlm.nih.gov]

Some authors associate weak Congo red staining of the fibrils with delayed disease onset and associate a strong affinity to Congo red with early presentation of the disease [cjasn.asnjournals.org]

Of note, in elderly Swedish patients with SSA (WT-TTR), postmortem analysis revealed minimal congophilic material in the renal cortex, although, as previously mentioned, SSA [cjasn.asnjournals.org]

Paraparesis

Congophilic angiopathy was present. There was mild patchy loss of pigmented neurons of the substantia nigra with no Lewy bodies. [academic.oup.com]

Bielschowsky silver stains of the cerebral cortex and hippocampus showed numerous NFTs, and many ‘cotton wool’ and classical neuritic plaques. [academic.oup.com]

Myositis

The Congo red stain demonstrates congophilic material in vacuolated fibers that is likely to represent amyloid deposition. [ncbi.nlm.nih.gov]

Myofibrillar Myopathy Type 3

Originalien Published: 23 December 2012 Zwei Fälle mit rein distalem Phänotyp der Beine Myofibrillary myopathy due to the ZASP mutation Ala147Thr Two cases with exclusively distal leg involvement Der Nervenarzt volume 84, pages 209–213 (2013)Cite this article 402 Accesses 4 Citations Metrics details Zusammenfassung Es[…] [link.springer.com]

Immunoglobulin Heavy Chain Deficiency

Nima Rezaei gained his medical degree from Tehran University of Medical Sciences in 2002 and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and[…] [books.google.de]

Hereditary Corneal Dystrophy

These are poorly visualized with routine hematoxylin-eosin staining; however, the lesions are congophilic and revealed as distinct amyloid deposits with Congo red staining [entokey.com]

Lattice Corneal Dystrophy Type 1

These are poorly visualized with routine hematoxylin-eosin staining; however, the lesions are congophilic and revealed as distinct amyloid deposits with Congo red staining [entokey.com]

Sarcotubular Myopathy

Congo red stained sections viewed underrhodamine optics revealed no congophilic deposits. [documents.tips]

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Left Ventricular Noncompaction

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Primary Amyloidosis

Hereditary Proximal Myopathy with Early Respiratory Failure

Variably contain: β amyloid, desmin, SMI-31 binding Cytoplasmic bodies (95%) Stain for F-actin (Phalloidin) "Necklace" pattern in muscle fibers 38 Muscle fiber splitting: [neuromuscular.wustl.edu]

Myofibrillar pathology : Cytoplasmic aggregates Contain: Actin ; Desmin In type I muscle fibers Myofibrillar pathology Not typical Cytoplasmic bodies Eosinophilic inclusions Congophilic [neuromuscular.wustl.edu]

Heavy Chain Disease

[…] the non-Congophilic deposits. [cjasn.asnjournals.org]

When the biopsy stains for a single HC isotype and does not stain for LC isotypes, the diagnosis of HCDD should be suspected. [cjasn.asnjournals.org]

[…] immunohistologic analysis of tissue from an affected organ, in most cases the kidney, using a panel of Ig chain-specific antibodies, including anti-κ and anti-λ LC antibodies to stain [cjasn.asnjournals.org]

Distal Myopathy Type 3

Variably contain: β amyloid, desmin, SMI-31 binding Cytoplasmic bodies (95%) Stain for F-actin (Phalloidin) "Necklace" pattern in muscle fibers 38 Muscle fiber splitting: [neuromuscular.wustl.edu]

Limb-Girdle Muscular Dystrophy

Pleomorphic hyaline, granular & amorphous deposits Congo red: Hyaline structures often Congophilic Abnormal fiber regions wthout oxidative enzyme activity Vacuoles: Small [neuromuscular.wustl.edu]

[…] inclusions: Few Myofibfillar stains: Rare desmin & αB-crystallin aggregates Ultrastructure: Cytoplasmic inclusions, 15–21 nm filaments Serum CK: Mildly high; 300 to 400 EMG [neuromuscular.wustl.edu]

Congo red: Some regions congophilic Autophagocytosis Nuclei: 7% to 8% show early apoptotic changes Denervation: Scattered esterase angular muscle fibers NOTE: αB-crystallin [neuromuscular.wustl.edu]

Limb-Girdle Muscular Dystrophy Type 1G

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Muscular Dystrophy-Dystroglycanopathy Type C4

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 2F

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 2E

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 1E

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 2Q

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 2J

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Muscular Dystrophy-Dystroglycanopathy Type C3

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Muscular Dystrophy-Dystroglycanopathy Type C5

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Limb-Girdle Muscular Dystrophy Type 2L

Abnormal hyaline structures are congophilic and contain many degraded proteins. Oxidative enzymes and ATPase activity is absent in the areas containing inclusions. [emedicine.medscape.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]