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4 Possible Causes for Conjugated Hyperbilirubinemia Type 3

  • Neurofibromatosis Type 1

    Laboratory investigations revealed iron deficiency anemia and conjugated hyperbilirubinemia. Tumor markers were normal.[ncbi.nlm.nih.gov] A 66-year-old lady with neurofibromatosis type 1 presented with painless progressive jaundice for six months.[ncbi.nlm.nih.gov] Abdominal computed tomography showed a 3 2 cm heterogenous mass in the periampullary region with mild dilation of the common bile duct and another 2 1.7 cm mass in the fourth[ncbi.nlm.nih.gov]

  • Gastrointestinal Stromal Tumor

    Laboratory investigations revealed iron deficiency anemia and conjugated hyperbilirubinemia. Tumor markers were normal.[ncbi.nlm.nih.gov] CASE PRESENTATION: A 66-year-old lady with neurofibromatosis type 1 presented with painless progressive jaundice for six months.[ncbi.nlm.nih.gov] Abdominal computed tomography showed a 3 2 cm heterogenous mass in the periampullary region with mild dilation of the common bile duct and another 2 1.7 cm mass in the fourth[ncbi.nlm.nih.gov]

  • Rotor Syndrome

    The molecular mechanism we identified in RS may also underlie a similar disorder called hepatic uptake and storage syndrome, or conjugated hyperbilirubinemia type III (OMIM[doi.org] This also applies to drug-drug interactions mediated through OATP1B1/3 inhibition.[doi.org]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    Clinical features • Severe pruritus • Conjugated hyperbilirubinemia • Low or normal levels of gamma glutamyl transpeptidase in types 1 and 2 • Serum bile acid concentrations[clinicalgate.com] […] in the bile salt export protein ( BSEP ) gene ABCB11 chromosome 2q24 codes for a protein expressed on the canaliculus • PFIC3 mutations in the multidrug resistance ( MDR 3[clinicalgate.com] […] are usually high decreased bile acids have also been reported in some cases • PFIC 3 carries a high risk for hepatocellular carcinoma in young children ( Knisely et al 2006[clinicalgate.com]

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