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14 Possible Causes for Conjunctival Pallor, Erythrocytes Decreased, Polychromasia in Peripheral Blood Smear

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[] The decrease of bilirubin and normal values of haptoglobin might be the concequence of diminished destruction of erythrocytes and their precursors.[]

  • Sideroblastic Anemia

    […] protoporphyrin), decreased ferrochelatase activity, and deletion of portions of the long arms of chromosomes 18 and 20.[] Blood Smear Peripheral blood smear images .[] Erythropoietic protoporphyria (EPP) is an autosomal dominant disorder due to the decreased activity of ferrochelatase.[]

  • Uremic Anemia

    […] in 38 hemodialysed patients was decreased and urea, creatinine and middle molecular substances had the effect on decreasing the osmotic resistance of erythrocyte in vitro[] A peripheral blood smear showed red blood cell fragmentation with a few schistocytes (asterisk, 6/high power field) and polychromasia (arrow).[] Deficient erythropoietin synthesis, iron deficiency, blood loss, and a decreased erythrocyte half-life are the main contributors to anemia associated with CKD.[]

  • Anemia due to Glutathione Metabolism Disorder

    Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[] The mild form of glutathione synthetase deficiency (OMIM 231900) is associated with decreased erythrocyte glutathione levels and well-compensated hemolytic disease.[]

  • Acquired Sideroblastic Anemia

    Clinical features, if present, are mostly nonspecific and may include fatigue, dyspnea , conjunctival pallor, and tachycardia .[] […] than the decrease in number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the[] Blood Smear Peripheral blood smear images .[]

  • Pancytopenia

    His exam is notable for conjunctival pallor and hepatosplenomegaly.[] One mechanism indicates direct effect of CMV on bone marrow cells leading to cellular injury and decrease of erythrocytes, lymphocytes, granulocytes, and platelets.[] blood smear examination for which Leishman stain was used.[]

  • Autoimmune Hemolytic Anemia

    On physical examination, conjunctival, buccal and/or nailbed pallor can be seen, depending on the degree of anemia.[] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[]

  • Hemolytic Anemia

    On physical examination, conjunctival, buccal and/or nailbed pallor can be seen, depending on the degree of anemia.[] In general, any condition which shortens erythrocyte survival or decreases mean erythrocyte age, such as autoimmune hemolytic anemia, hereditary spherocytosis and elliptocytosis[] Mean corpuscular volume was 96 fl, and the reticulocyte count was 11%, with marked polychromasia on peripheral smear.[]

  • Normocytic Normochromic Anemia

    Conjunctival pallor is a reliable sign, and its presence should prompt the clinician to order blood tests for anemia. 6 Aside from conjunctival pallor, few other signs are[] Microcytic anemia is characterized by a decrease in size of erythrocytes.[] Peripheral blood smear shows: Microcytosis and hypochromasia. There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs).[]

  • Zieve's Syndrome

    Physical examination was remarkable for scleral icterus, conjunctival pallor, and a dry oral mucosa.[] We suggest that this decrease in erythrocyte turnover helps to ameliorate hypertriglyceridemia.[] The patient's peripheral smear showed polychromasia, macrocytosis, tear drop cells, ovalocytes, spur cells, and schistocytes ( Figure 1 ).[]

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