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229 Possible Causes for corepressor

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  • Y-Linked Deafness 1

    Recently, it has been shown that TBLR1, another homologue whose gene resides on chromosome 3, and TBL1X act as a corepressor/coactivator exchanger for several nuclear receptors[link.springer.com] Cell 63:1205–1218 Google Scholar Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (2000) A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40[link.springer.com] EMBO J 22:1336–1346 Google Scholar Zhang J, Kalkum M, Chait BT, Roeder RG (2002) The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the[link.springer.com]

  • Retinoid

    As a result, TBLR1-RARα exhibited diminished transcriptional activity by recruitment of more transcriptional corepressors compared with RARα.[ncbi.nlm.nih.gov] (NCoR) and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressors and is largely unresponsive to ligand activation.[ncbi.nlm.nih.gov] Activation and regulation of RXR heterodimers is achieved by complex allosteric mechanisms, which involve the binding of ligands, DNA, coactivators and corepressors, and entail[ncbi.nlm.nih.gov]

  • Horseshoe Kidney

    B-cell lymphoma 6 corepressor (BCOR) gene internal tandem duplication (ITD) was identified as a recurrent somatic alteration in approximately 85% of CCSKs.[ncbi.nlm.nih.gov]

  • Mifepristone

    Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor Mol. Endocrinol. 18(1), (2004) . 3.[caymanchem.com]

  • Rosiglitazone

    Interestingly, further experiments showed RGL reversed LPS-induced nuclear receptor corepressor (NCoR) degradation.[ncbi.nlm.nih.gov]

  • Renal Cell Carcinoma

    […] investigations showed that LUCAT1 induced cell cycle G1 arrest by regulating the expression of cyclin D1, cyclin-dependent kinase 4, and phosphorylated retinoblastoma transcriptional corepressor[ncbi.nlm.nih.gov]

  • Neonatal Hyperbilirubinemia

    In this study, we report that deletion of intestinal nuclear receptor corepressor 1 (NCoR1) completely diminishes hyperbilirubinemia in hUGT1 neonates because of intestinal[ncbi.nlm.nih.gov]

  • Marginal Zone Lymphoma

    All TBL1XR1 mutations were located within the WD40 domain, and TBL1XR1 mutants transfected into 293T cells increased TBL1XR1 binding with nuclear receptor corepressor (NCoR[ncbi.nlm.nih.gov]

  • Bronchiolitis Obliterans

    Analysis of miR-144 in the biopsy specimens demonstrated 4.1 0.8-fold increases in BOS( ) compared with BOS(-) patients, with a significant reduction in TGIF1 (3.6 1.2-fold), a corepressor[ncbi.nlm.nih.gov]

  • Mowat-Wilson Syndrome

    The zinc finger homeo box 1 B (Smad interacting protein-1) is a transcription corepressor of Smad target genes with functions in the patterning of neural crest derived cells[ncbi.nlm.nih.gov] ZFHX1B encodes Smad-interacting protein-1 (SMADIP1 or SIP1), a transcriptional corepressor involved in the transforming growth factor-beta signaling pathway.[ncbi.nlm.nih.gov]

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