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15 Possible Causes for Corneal Infiltrate, High Density Lipoprotein Decreased

  • Lecithin Acyltransferase Deficiency

    A 20-year-old male of Indian extraction presented with visual impairment principally due to bilateral diffuse punctate corneal infiltration, with peripheral ring opacities[tandfonline.com] They showed a marked decrease in plasma high density lipoproteins (HDL) and a decrease in the ester ratio of plasma total cholesterol.[ncbi.nlm.nih.gov] This is the first report of lecithin-cholesterol acyltransferase deficiency in Iran.The diagnosis was confirmed by a low high-density lipoprotein cholesterol concentration[ncbi.nlm.nih.gov]

  • Hypercholesterolemia

    These include a soft tissue mass on a tendon caused by cholesterol deposits called a xanthoma and a grayish-white ring on the cornea due to lipid infiltration known as a corneal[nsgc.org] Traditionally, risk factors for cardiovascular disease in adults have included elevated levels of low-density lipoprotein (LDL), decreased levels of high-density lipoprotein[pediatricheartspecialists.com] However, blood total cholesterol, low-density lipoprotein cholesterol, and hepatic cholesterol were elevated by the HCD compared to ND, and those concentrations were decreased[ncbi.nlm.nih.gov]

  • Heterozygous Familial Hypercholesterolemia

    D: Arcus cornealis results from cholesterol infiltration around the corneal rim (arrow).[ncbi.nlm.nih.gov] Beyond that, hypertension, a family history of cardiovascular disease, diabetes mellitus, elevated lipoprotein(a), smoking, male sex, and low levels of high-density lipoproteins[symptoma.com] The treatment target was achievement of low-density lipoprotein cholesterol (LDL-C) levels 1.8 mmol/l for very high CV risk patients and 2.6 mmol/l for high CV risk patients[termedia.pl]

  • Arcus Senilis

    infiltrate, often with overlying epithelial defect • Lecithin-cholesterol acetyltransferase (LCAT) deficiency: Corneal opacity resembling arcus senilis in patients with LCAT[entokey.com] Xanthelasma: clinical indicator of decreased levels of high-density lipoprotein cholesterol. South Med J 1989 ; 82 : 570 -4.[doi.org] It is due to a lipid infiltration of the corneal stroma. With age the condition progresses to form a complete ring.[medical-dictionary.thefreedictionary.com]

  • Rheumatoid Arthritis

    Scleritis and corneal ulcerations are rare but more serious problems. Sjogren’s Syndrome.[hopkinsarthritis.org] Serum lipoprotein(a) level was found to be significantly increased and high-density lipoprotein significantly decreased in women who have RA compared with healthy women. 15[web.archive.org] Approximately 10 to 15% of patients with rheumatoid arthritis develop Sjogren’s syndrome , a chronic inflammatory disorder characterized by lymphocytic infiltration of lacrimal[hopkinsarthritis.org]

  • Arcus Juvenilis

    infiltrate, often with overlying epithelial defect • Lecithin-cholesterol acetyltransferase (LCAT) deficiency: Corneal opacity resembling arcus senilis in patients with LCAT[entokey.com] The serum high density lipoprotein was decreased. Renal function test revealed elevated serum creatinine with significant proteinuria.[ncbi.nlm.nih.gov] Xanthelasma: clinical indicator of decreased levels of high-density lipoprotein cholesterol. South Med J 1989 ; 82 : 570 -4.[bmj.com]

  • Tangier Disease

    The combination of exposure keratopathy and corneal infiltration can cause significant visual impairment.[ncbi.nlm.nih.gov] Tangier's Disease (main mutations) FHA Signs/symptoms: Decreased high density lipoprotein (HDL) cholesterol. Orange tonsils, enlarged spleen, lymph nodes, hepatomegaly.[diagene.ch] Tangier disease (TD) (OMIM#205400) is a rare autosomal recessive disorder resulting from mutations in the ABCA1 gene, leading to decreased levels of plasma high-density lipoproteins[ncbi.nlm.nih.gov]

  • Hyperlipidemia Type 5

    […] arcus 0001084 Diabetes mellitus 0000819 Hepatic steatosis Fatty infiltration of liver Fatty liver [ more ] 0001397 Hepatomegaly Enlarged liver 0002240 Obesity Having too[rarediseases.info.nih.gov] […] circulating high-density lipoprotein cholesterol Decreased HDL cholesterol Low HDL-cholesterol [ more ] 0003233 Decreased LDL cholesterol concentration 0003563 Diabetes mellitus[rarediseases.info.nih.gov] Furthermore, decreased high-density lipoprotein (HDL) cholesterol is commonly seen among patients with all types of HTG.[mdpi.com]

  • Xanthoma Disseminatum

    Ocular examination revealed conjunctival and left corneal infiltration by yellow minute papules with normal visual field.[jpgmonline.com] Fenofibrate, the final combination agent, activates PPARα and improves high density lipoprotein functions such as reverse cholesterol transport and anti-inflammatory activity[ncbi.nlm.nih.gov] Corneal xanthoma in childhood. Arch Ophthalmol 1966; 76 :221–9. 5 DeBarge LR, Chan CC, Greenberg SC, McLean IW, Yannuzzi LA, Nussenblatt RB.[nature.com]

  • Oculomotor Apraxia

    On examination, an irregular, granular, perilimbic corneal infiltrate is observed. In most cases, both eyes are affected during the disease course.[hindawi.com] Hypercholesterolaemia was noted in 75% of patients, with elevated levels of low density lipoprotein cholesterol and low levels of high density lipoprotein cholesterol ( n[academic.oup.com] On examination of patients with IK, an irregular, granular corneal infiltration is observed, affecting particularly the posterior part of the cornea, near the limbus.[rheumatology.oxfordjournals.org]

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