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18 Possible Causes for Corneal Opacity, Onset of Skin Lesions at Birth

  • Winchester Syndrome

    The syndrome is characterized by short stature, coarse face, corneal opacities, generalized osteolysis and progressive painful arthropathy with joint stiffness and contractures[ncbi.nlm.nih.gov] Other manifestations include pigmented lesions on the skin, coarse facies, corneal opacities, and cardiac defects. Most affected children are apparently normal at birth.[ncbi.nlm.nih.gov] Abstract The Winchester syndrome, a rare inherited disorder, is characterized by dwarfism, carpal-tarsal osteolysis, rheumatoid-like small joint destruction, corneal opacities[ncbi.nlm.nih.gov]

  • Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum

    Other features of MONA can include clouding of the clear front covering of the eye (corneal opacity), excess hair growth (hypertrichosis), overgrowth of the gums, heart abnormalities[ncbi.nlm.nih.gov] Onset is usually between ages six months and six years (range: birth to 11 years).[ncbi.nlm.nih.gov] Various additional features including coarse face, corneal opacities, gum hypertrophy, and EKG changes have been reported.[malacards.org]

  • Late Congenital Syphilis

    Stigmata due to late congenital syphilis are perforation of palate, corneal opacities, optic atrophy and periosteal changes of tibia. [6] The transmission of infection to[ijstd.org] Syphilis, Congenital also see TORCH Onset of symptoms may be from birth to 3 months of age.[johnsarm.net] Eyes revealed dense corneal opacities with complete loss of vision in right eye. Left eye was normal. Patient was edentulous.[ijdvl.com]

  • Palmoplantar Keratosis

    Linear and star-like corneal opacities in the epithelium resembling dendrites (pseudodendritic keratitis) have been described together with thickening of the conjunctiva.[disorders.eyes.arizona.edu] It is the combination of family history of both tylosis and oesophageal cancer, late onset skin lesions (i.e. substantially after birth but before puberty) and, more recently[ojrd.biomedcentral.com] Unna-Thost disease is commonly associated with secondary fungal and bacterial infections. [1] Corneal opacities, pilitorti, hearing loss, hypohidrosis and dental abnormalities[faoj.org]

  • Ophthalmia Neonatorum

    These seven were subjected to irritation testing using three separate methods: the bovine corneal opacity and permeability (BCOP) test; the hen's egg test-chorioallantoic[ncbi.nlm.nih.gov] Viral conjunctivitis Onset is acute, 1-14 days after birth: unilateral/bilateral serosanguinous discharge vesicular skin lesions.[patient.info] These seven were subjected to irritation testing using three separate methods: the bovine corneal opacity and permeability (BCOP) test; the hen’s egg test—chorioallantoic[mbio.asm.org]

  • Gonococcal Conjunctivitis

    Figure 3 After the antibiotics were initiated for 3 weeks, the cornea was normal without corneal epithelial defect and corneal opacity in the right eye and the conjunctiva[nature.com] Viral conjunctivitis The onset is acute usually 1-14 days after birth: unilateral/bilateral serosanguinous discharge vesicular skin lesions.[intechopen.com] Foreign body sensation and corneal opacity on penlight exam. Red flags : Severe pain/photophobia/decreased acuity.[hopkinsguides.com]

  • Chorioretinitis

    ); sclerosing keratitis (severe inflammatory changes seen in the cornea associated with corneal scarring); and iridocyclitis (inflammatory changes seen in the iris) ( Hise[doi.org] […] system Most common findings are respiratory distress syndrome and skin lesions May be associated with signs of meningitis Transmission during birth, postnatally via contact[amboss.com] opacities reported) Sclerosing keratitis % new cases Dichotomous E H E Iridocyclitis % new cases Dichotomous E E Chorioretinitis % new cases Dichotomous E Optic nerve disease[doi.org]

  • Howell-Evans Syndrome

    […] white dot opacities) NSDHL (NADPH steroid dehydrogenase) CHILD syndrome gene defect NSDHL (NADPH steroid dehydrogenase-like protein) Conradi-Hunermann-Happle Syndrome EBP[brainscape.com] It is the combination of family history of both tylosis and oesophageal cancer, late onset skin lesions (i.e. substantially after birth but before puberty) and, more recently[ojrd.biomedcentral.com] […] sulfatase (STS), arlysulfatase C Lamellar ichthyosis gene defect Gene defect in Sjogren Larsson syndrome FALDH gene ("fall down" - bc they have spastic dtetraplegia and the corneal[brainscape.com]

  • Rambaud-Gallian Syndrome

    “Acute Symptoms in the Neonatal Period: Neonatal Metabolic Distress”) Hyperventilation attacks ( Table 66-37 ) Ocular Symptoms Cataracts ( Table 66-38 ) Corneal opacity ([ommbid.mhmedical.com] Onset is at birth or during the neonatal period. The skin lesions may affect the entire body, or may manifest on palms and soles or head and scalp only.[findzebra.com] Last update: August 2006 Hashimoto-Pritzker histiocytosis (HPH) is a variant of Langerhans cell histiocytosis (see this term) characterized by multiple disseminated skin lesions[findzebra.com]

  • Congenital Herpes Simplex Infection

    opacities, and eyelid colobomas) sporadic 4 ACC with embryologic malformations: meningomyelocele, porencephaly, leptomeningeal angiomatosis, cranial stenosis, spinal dysraphism[scielo.br] […] system Most common findings are respiratory distress syndrome and skin lesions May be associated with signs of meningitis Transmission during birth, postnatally via contact[amboss.com] Some patients have also had ophthalmic and neurologic findings typical of epidermal nevus syndrome , including seizures, mental retardation, corneal opacities, and eyelid[emedicine.medscape.com]

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