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17 Possible Causes for Corneal Opacity, Thickening of the Mitral Valve Leaflets

  • Mucopolysaccharidosis

    Regardless of phenotype, all patients had various degrees of infiltrated facies, short stature, dysostosis multiplex, joint contractures, and corneal opacity typical of the[ncbi.nlm.nih.gov] The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema.[icd9data.com] Typical symptoms are stiff joints, corneal opacities, carpal tunnel syndrome and mild skeletal changes. Aortic valve disease can be present.[orpha.net]

  • Mucopolysaccharidosis 1 H-S

    Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[ncbi.nlm.nih.gov] Corneal opacity is seen between two and four years of age and requires keratoplasty to restore sight.[orpha.net] Typical symptoms include stiff joints, corneal opacities, carpal tunnel syndrome and mild skeletal changes.[cags.org.ae]

  • Fabry Disease

    […] without significant luminal occlusion. c Section through the mitral valve apparatus demonstrating mild mitral valve leaflet thickening and ballooning of the anterior and[doi.org] opacity, lysosomal disease with restrictive cardiomyopathy, lysosomal disease with hypertrophic cardiomyopathy, rare hereditary metabolic disease with peripheral neuropathy[commons.wikimedia.org] Valves were examined for the presence of focal or diffuse thickening of the leaflets or subvalvular apparatus (for the mitral valve).[pediatrics.aappublications.org]

  • Mucopolysaccharidosis 4

    […] minimal to mild thickened mitral and/or aortic valve leaflets.[journals.plos.org] To give a synopsis of the disease: There is severe growth retardation (adult height 82 to 115 cm); the skull is unusually thick and dense; there are corneal opacities (clouding[medicinenet.com] They presented marked growth retardation, spinal deformity, chest deformity, genu valgum, and corneal opacities.[cags.org.ae]

  • Mucopolysaccharidosis 1

    Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[ncbi.nlm.nih.gov] Typical symptoms are stiff joints, corneal opacities, carpal tunnel syndrome and mild skeletal changes. Aortic valve disease can be present.[orpha.net] opacities, clawhand, aortic valve disease, normal stature, mild or absent intellectual impairment, and nearly normal life span, depending on cardiac complications.[icd10data.com]

  • Mucopolysaccharidosis 4A

    Valvular involvement, with thickening and stiffening of the valve leaflets, commonly leads to mitral and aortic regurgitation and/or stenosis [ 24 ].[link.springer.com] Cornea Corneal opacities are universally present in all forms of MPS I.31 Fine grey punctate opacities are first seen in the anterior stroma; later, as the disease progresses[touchophthalmology.com] Slowly progressive corneal clouding, found in 50% of affected individuals (ages 1-65 years), is the most common ophthalmologic finding in MPS IVA.[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 2

    Fig. 1 Subcostal echocardiographic view showing anterior (arrowhead) and posterior mitral valve thickening with subvalvular involvement (asterisk).[karger.com] Mucopolysaccharidosis II (Hunter disease) with corneal opacities. Report on two patients at the extremes of a wide clinical spectrum.[emedicine.medscape.com] The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema.[icd10data.com]

  • Autosomal Dominant Deafness 28

    The major risk factors for cerebrovascular events include age older than 50 years, thickened mitral valve leaflets, atrial fibrillation and a need for mitral valve surgery[patient.info] Congenital corneal opacities present in approximately 3/100,000 newborns [ 40 ].[link.springer.com] Mitral valve prolapse (MVP) is an abnormal bulging of one or both of the mitral valve leaflets into the left atrium during ventricular systole. [ 1 ] MVP is defined on echocardiography[patient.info]

  • Mucopolysaccharidosis 1S

    Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[ncbi.nlm.nih.gov] In this series, the occurrence of some clinical features linked to the Scheie syndrome is consistent with the literature, such as systematic valvulopathies, corneal opacity[mdpi.com] opacity, and hearing impairment. 2–4 Neurological manifestations may differ considerably depending on the type of MPS.[elsevier.es]

  • Congenital Stenosis of the Inferior Vena Cava

    MRI: mildly thickened anterior mitral valve leaflet.[my.clevelandclinic.org] […] size and shape Microcornea Excludes: that associated with buphthalmos (743.22) 743.42 Corneal opacities, interfering with vision, congenital 743.43 Other corneal opacities[theodora.com] I feel mild SOB when take a walk sometimes, but most of the time I can still travel around. 1) Can MR be a complication post-myectomy since the surgeon excised my thickening[my.clevelandclinic.org]

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