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2,970 Possible Causes for Cornified Cell Envelope, Eosinophilia, Palmar Hyperlinearity

  • Atopic Dermatitis

    We present the case of a 6 year old patient that developed de novo atopic dermatitis, eosinophilia and high levels of total IgE under systemic treatment with tacrolimus.[ncbi.nlm.nih.gov] Among patients, reduced level of monomeric filaggrin and NMF correlated with the presence of FLG mutations and clinical phenotypes such as xerosis, palmar hyperlinearity and[ncbi.nlm.nih.gov] A major predisposing factor for AD is the existence in many patients of a mutation in the gene encoding for the filaggrin protein, which is a component of the cornified cell[merckmanuals.com]

  • Peeling Skin Syndrome Type A

    A rare autosomal recessive form of congenital, ichthyosis characterised by peeling of skin, erythema, pruritus, short stature, eosinophilia, increased IgE A rare autosomal[medical-dictionary.thefreedictionary.com] Palmar and plantar areas are spared or present erythema, slight thickening of the skin or palmar hyperlinearity. An underlying erythroderma is present.[sites.uclouvain.be] A shortage of transglutaminase 5 weakens the cornified cell envelope, which allows the outermost cells of the epidermis to separate easily from the underlying skin and peel[ghr.nlm.nih.gov]

  • Ichthyosis Vulgaris

    The main characteristics of IV are fine-scale on the arms and legs, palmar hyperlinearity, and keratosis pilaris.[ncbi.nlm.nih.gov] The resultant matrix is cross-linked to form a major component of the cornified cell envelope.[ncbi.nlm.nih.gov] cell envelope (CCE).[flipper.diff.org]

    Missing: Eosinophilia
  • Congenital Non-Bullous Ichthyosiform Erythroderma ARCI2

    \n\nIchthyosis prematurity syndrome (608649) is a self-improving form of\nichthyosis that includes respiratory complications at birth and\npersistent eosinophilia and is caused[lifemodules.org] hyperlinearity were observed.[ncbi.nlm.nih.gov] Ichthyosis prematurity syndrome ({608649}) is a self-improving form of ichthyosis that includes respiratory complications at birth and persistent eosinophilia and is caused[diseaseinfosearch.org]

  • Ichthyosis

    Consequently, defects in epidermal barrier function lead to pruritus, a susceptibility to skin infections and AD (often with elevation of total immunoglobulin E levels and eosinophilia[onlinelibrary.wiley.com] Palms and soles show accentuated creases and when affecting the palms this sign is referred to as palmar hyperlinearity or as “ichthyosis palms”.[medizin.uni-muenster.de] cell envelope of the upper epidermis and leads to defective cornification and desquamation. [9], [10] The severity of symptoms can vary, from the mildest types such as ichthyosis[ijpd.in]

  • Peeling Skin Syndrome

    Three consanguinous newborn babies had a congenital ichthyosis with eosinophilia and elevated total immunoglobulin E.[ncbi.nlm.nih.gov] cornified cell envelope.[ncbi.nlm.nih.gov] Inflammatory/Type B PSS: Laboratory tests classically show evidence of atopy including eosinophilia and elevated IgE.[dermatologyadvisor.com]

    Missing: Palmar Hyperlinearity
  • Acral Peeling Skin Syndrome

    Inflammatory/Type B PSS: Laboratory tests classically show evidence of atopy including eosinophilia and elevated IgE.[dermatologyadvisor.com] Cystatin A is a protease inhibitor found in the cornified cell envelope, and loss-of-function mutations have previously been reported in two cases of exfoliative ichthyosis[ncbi.nlm.nih.gov] Some cases result from mutations in the TGM5 gene that encodes transglutaminase 5, which has an important role in cross-linking cornified cell envelope proteins.[ncbi.nlm.nih.gov]

    Missing: Palmar Hyperlinearity
  • Atopy

    It can be concluded that nasal cytology with eosinophilia assessment can be a useful tool for an early diagnosis of atopic disease in children.[ncbi.nlm.nih.gov] Smoking, age above 40 years, and blood eosinophilia may affect a good outcome for atopy. Poorly controlled asthma may lead to many long-term changes in the body.[symptoma.com] Weiss Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels [4.] L.R.[archbronconeumol.org]

    Missing: Cornified Cell Envelope Palmar Hyperlinearity
  • Lamellar Ichthyosis

    , rheumatism, dermatitis; articular nodules, dermographism, episodic hand & foot edema, eosinophilia, generalized pruritic dermatitis, urticaria Netherton's s.[readbag.com] Ultrastructural examination revealed incomplete formation of cornified cell envelopes and electron-dense materials adjacent to plasma membranes.[ncbi.nlm.nih.gov] Malformation of the cornified cell envelope (CCE) arising from mutations of the transglutaminase (TGase) 1 gene (TGM1) is the cause of some cases of lamellar ichthyosis (LI[ncbi.nlm.nih.gov]

    Missing: Palmar Hyperlinearity
  • Ichthyosis-Prematurity Syndrome

    When examined at 2–37 years of age, all patients exhibited skin xerosis, fine or focal scaling (Fig. 1c), palmar hyperlinearity or keratoderma, and frequent occurrence of[medicaljournals.se] Many patients also develop food/respiratory allergies with elevated IgE levels and eosinophilia.[nature.com] […] characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia[orpha.net]

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