Cortical Dysplasia: Causes & Reasons

Possible Causes for Cortical Dysplasia

[…] encephalopathy, and cortical dysplasia. [ncbi.nlm.nih.gov]

The underlying etiology consisted of lissencephaly, Down's syndrome, and focal cortical dysplasia. [ncbi.nlm.nih.gov]

With the exception of a discussion of focal cortical dysplasias, most of the information in chapters on the known etiologic causes of infantile spasms is familiar to neurologists [nejm.org]

Trisomy 12p

Structural brain abnormalities include polymicrogyria and focal cortical dysplasia. [epilepsydiagnosis.org]

[…] sulci and cisterna magna; hemispheric atrophy with microgyria; internal hydrocephalus; cortical dysplasia; ectopic glial tissue in the leptomeninges; and bilateral small [synapse.koreamed.org]

[…] have been reported in association with trisomy 12p.461314 Central nervous system abnormalities include moderate ventricular dilatation; enlargement of sylvian fissures, cortical [synapse.koreamed.org]

Congenital Muscular Dystrophy

In view of cortical dysplasia with characteristic distribution, cerebellar abnormalities, preserved general configuration of the brain and normal ophthalmologic examination [neurologyindia.com]

Merosin-negative congenital muscular dystrophy, occipital epilepsy with periodic spasms and focal cortical dysplasia. Report of three Italian cases in two families. [ncbi.nlm.nih.gov]

dysplasia or cerebellar hypoplasia.8'9 Cognitive function generally is normal in children with isolated white matter changes but can be impaired in patients with additional [healio.com]

Angiocentric Glioma

Associated cortical dyslamination consistent with cortical dysplasia was found in the surrounding cortex. [ncbi.nlm.nih.gov]

OBJECTIVE: To describe the clinicopathologic features of 5 angiocentric gliomas and to evaluate for coexistent malformation of cortical development/cortical dysplasia. [ncbi.nlm.nih.gov]

Some patients with AG present focal cortical dysplasia. [ncbi.nlm.nih.gov]

Ganglioglioma

We report 2 cases of triple pathology including hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia. [ncbi.nlm.nih.gov]

The pathology included desmoplastic infantile ganglioglioma (DIG) and extensive focal cortical dysplasia in the overlying cortex. [ncbi.nlm.nih.gov]

A subset of composite tumors are associated with adjacent focal cortical dysplasia. [ncbi.nlm.nih.gov]

Rasmussen Syndrome

Less than 10% of T cells isolated from brain specimens from eight surgical cases of focal cortical dysplasia (FCD), a condition that is also characterized by intractable seizures [ncbi.nlm.nih.gov]

Special Consideration: Epilepsy Surgery for Rasmussen’s Encephalitis In this section : Tuberous Sclerosis Complex | Focal Cortical Dysplasia | Hemimegalencephaly | Rasmussen [uclahealth.org]

Sometimes, Ramussen’s encephalitis can also include cortical dysplasia. There is no known cause or cure for Rasmussen’s encephalitis. [brainrecoveryproject.org]

Temporal Lobe Epilepsy

Focal cortical dysplasia (FCD) represents a common cause of refractory epilepsy. [ncbi.nlm.nih.gov]

dysplasia. 2010 Elsevier Ltd. [ncbi.nlm.nih.gov]

[…] cavernous malformation AVM It is essential to review the whole scan carefully as there is a high (5-20%) incidence of dual pathology, especially in cases of cortical dysplasia [radiopaedia.org]

Congenital Merosin-Positive Muscular Dystrophy

These were associated with bilateral occipital posterior cortical dysplasia. The 190 VALENTINA T. [repositorio.chporto.pt]

These were associated with bilateral occipital posterior cortical dysplasia. [actamedicaportuguesa.com]

Magnetic resonance imaging findings were consistent with pontocerebellar hypoplasia, bilateral opercular abnormalities and focal cortical dysplasia as well as minute periventricular [discovery.ucl.ac.uk]

Polymicrogyria

Advanced neuroradiologic and neurophysiologic techniques are required to provide an effective and safe resection of the epileptogenic cortex in cortical dysplasias. [ncbi.nlm.nih.gov]

Among the more frequently identified are cortical dysplasia, pachygyria, and polymicrogyria. The pathogenesis of these common developmental anomalies remains uncertain. [ncbi.nlm.nih.gov]

dysplasia type II, hemimegalencephaly, or tuberous sclerosis. [medlink.com]

Aprosencephaly and Cerebellar Dysgenesis

Congenital pseudoporencephaly Cortical dysplasia Cortical dysplasia with hemimegalencephaly Cystic malformation of posterior fossa Defect of telencephalic division Derodidymis [emedcodes.com]

dysplasia Cortical dysplasia with hemimegalencephaly Cystic malformation of posterior fossa Defect of telencephalic division Derodidymis Dural arteriovenous malformation [icd9data.com]

Pathology: Cytoarchitectonically, it is similar to the focal cortical dysplasia. Tumor-like, dense nodules (tubers) are found in the cortex. [tankonyvtar.hu]

Congenital Cerebral Cyst

 Focal cortical dysplasia  Heterotopic grey matter  Porencephaly  Arachnoid cyst  Cystic tumor 8.  Focal cortical dysplasia ◦ sometimes may have a cleft on the cortical [slideshare.net]

[…] surface focal cortical dysplasia may have a cleft on the cortical surface that does not extend completely to the ventricular surface heterotopic grey matter assessing the [radiopaedia.org]

dysplasia, pontocerebellar atrophy, ocular abnormalities, myopathy, elevated serum creatine kinase levels, and hemolytic anemia. [pubfacts.com]

Warburg Micro Syndrome 3

dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. [malacards.org]

Abstract : Warburg MICRO Syndrome is a rare, autosomal recessive syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical [hal.archives-ouvertes.fr]

Definition A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum [uniprot.org]

Developmental and Epileptic Encephalopathy Type 2

A surgically treated case of early-infantile epileptic encephalopathy (EIEE) with suppression-bursts associated with focal cortical dysplasia is reported. [ncbi.nlm.nih.gov]

Magnetic resonance imaging (MRI) suggested focal cortical dysplasia in the left prefrontal area. [ncbi.nlm.nih.gov]

Neuroimaging study showed no brain abnormalities in the female patient, while it revealed in the male patient a bilateral asymmetrical cortical dysplasia. [moh-it.pure.elsevier.com]

Epilepsia Partialis Continua

Cortical dysplasia has been increasingly recognized as a cause of epilepsy. [ncbi.nlm.nih.gov]

Rarely, EPC may also present in association with cortical dysplasia. [ncbi.nlm.nih.gov]

MRI showed focal megaencephaly around the motor cortex suggestive of cortical dysplasia. [ncbi.nlm.nih.gov]

Septo-Optic Dysplasia

Except for schizencephaly, the association of septo-optic dysplasia with another major type of disorder of neuronal migration and organization such as cortical dysplasia, [ncbi.nlm.nih.gov]

The term SOD-Plus was recently proposed to describe SOD associated with cortical dysplasia. [ncbi.nlm.nih.gov]

The association of septo-optic dysplasia and cortical dysplasia is described as septo-optic dysplasia-plus. [ncbi.nlm.nih.gov]

Autosomal Recessive Primary Microcephaly Type 10

[…] find publications by category + 745 results match your criteria cerebellar cortical dysplasia De Novo Mutated TUBB2B Associated Pachygyria Diagnosed by Medical Exome Sequencing [pubfacts.com]

Dysplasia, Complex, With Other Brain Malformations 5 Costello Syndrome Crane-Heise Syndrome Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardationsyndrome Craniofacial [familydiagnosis.com]

dysplasia, complex, with other brain malformations 1, 614039 KIF2A Cortical dysplasia, complex, with other brain malformations 3, 615411 TUBG1 Cortical dysplasia, complex [gsdseq.ir]

Subcortical Band Heterotopia

We have studied the coding regions of the DCX gene in 11 Japanese patients with cortical dysplasia and have identified three different mutations (R186C in exon 3, R272X and [ncbi.nlm.nih.gov]

The method was introduced to improve the visualization of blurred gray-white matter junctions associated with focal cortical dysplasia but was found to be applicable also [ncbi.nlm.nih.gov]

Nivelon-Nivelon-Mabille Syndrome

dysplasia Non-small cell lung cancer Nonallergic atopic dermatitis Noninsulin-dependent diabetes mellitus with deafness Nonketotic hyperglycinemia Nonmedullary thyroid carcinoma [mindmappedia.com]

dysplasia Nonmedullary thyroid carcinoma, with cell oxyphilia Nonne-Milroy disease Non-small cell lung cancer Nonsyndromic hereditary hearing impairment Noonan like syndrome [wikidoc.org]

[…] congenital stationary Nijmegen Breakage Syndrome Nivelon Nivelon Mabille syndrome Noble Bass Sherman syndrome Non functioning pancreatic endocrine tumor Non-lissencephalic cortical [mindmappedia.com]

Acquired Porencephaly

Individual chapters describe subgroups including lissencephalies, subependymal heterotopia, non-lissencephalic cortical dysplasias, anomalies of the corpus callosum, hemimegalencephaly [books.google.com]

Three had developmental causes (one hemimegalencephaly, one global cortical dysplasia and one bilateral porencephaly), acquired in 1 perinatal ischemic insult, and progressive [neurology.org]

Lennox-Gastaut Syndrome

We report, here, a patient with LGS and focal cortical dysplasia, who became seizure-free after epilepsy surgery. [ncbi.nlm.nih.gov]

However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable [ncbi.nlm.nih.gov]

LGS is usually caused by bilateral diffuse encephalopathy but localized cortical lesions, such as cortical dysplasia, cortical tuberous sclerosis, tumor, band heterotopia, [ncbi.nlm.nih.gov]

Hemimegalencephaly

The classification of cerebral cortical dysplasia is difficult and there are histological similarities between focal cortical dysplasia (FCD) and hemimegalencephaly. [ncbi.nlm.nih.gov]

[…] due to cortical dysplasia. [hemifoundation.homestead.com]

Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy. [ncbi.nlm.nih.gov]

Tuberous Sclerosis

Little is known about the relation between cortical dysplasia and ASD severity in TSC. [ncbi.nlm.nih.gov]

KEYWORDS: Epilepsy; Focal cortical dysplasia; Phospholipase C delta 1; Transient receptor potential channel 4; Tuberous sclerosis complex [ncbi.nlm.nih.gov]

On imaging, he was noted to have multiple lesions in the left parietal and temporal lobes consistent with focal cortical dysplasia and a subependymal nodule. [ncbi.nlm.nih.gov]

Spondyloepimetaphyseal Dysplasia-Hypotrichosis Syndrome

[…] non-pleiotropic Spastic paraplegia 10, autosomal dominant (SPG10) [MIM: 604187 ] KIF5C O60282 non-pleiotropic Cortical dysplasia, complex, with other brain malformations [sbg.bio.ic.ac.uk]

[…] plastica Intermittent hydrarthrosis Lennox-Gastaut syndrome Pilomatrixoma TRAPS syndrome Zonular cataract Familial atrial fibrillation Tetralogy of Fallot Isolated focal cortical [csbg.cnb.csic.es]

See Anhidrotic ectodermal dysplasia, Congenital hip dysplasia, Coronal dysplasia, Cortical dysplasia, Familial focal facial dermal dysplasia, Fibrodysplasia ossificans progressiva [medical-dictionary.thefreedictionary.com]

Medial Sclerosis

Cortical Dysplasia Cortical dysplasia is a congenital abnormality in the brain’s development. Congenital means that the condition was present at birth. [inova.org]

Cortical dysplasia Cortical dysplasia is a congenital abnormality in the brain’s development. Congenital means that the condition was present at birth. [inova.org]

[…] focal cortical dysplasia. [radiologyassistant.nl]

Monosomy 21q

I and J, Generalized cortical dysplasia. [nature.com]

Multiple malformations including structural brain malformations (e.g. cerebral atrophy, cortical dysplasia, and corpus callosum dysgenesis) and heart defects (e.g. patent [orpha.net]

Regions deleted in individuals with cortical dysplasia ( black ); regions deleted in individuals without cortical dysplasia ( gray ). [nature.com]

Severe Neonatal-Onset Encephalopathy with Microcephaly

dysplasia 25799227 NDE1 Lissencephaly with microcephaly (AR), plus deletion a risk factor for generalized epilepsy 21529751 PCDH19 Epilepsy in females with mental retardation [tests.labmed.washington.edu]

dysplasia With cerebellar hypoplasia Diffuse white matter changes WM changes and cortical dysplasia WM changes and cerebellar hypoplasia Laminin α2 (merosin) 6q2 CMD with [mrineonatalbrain.com]

Dysplasia-Focal Epilepsy Syndrome PTHSL1 CDFES 610042 Genetic Test Registry Pitt-Hopkins-Like Syndrome 2 PTHSL2 614325 Genetic Test Registry Rett Syndrome Autism, Dementia [ukgtn.nhs.uk]

Familial Infantile Myoclonic Epilepsy

dysplasia-focal epilepsy syndrome C12orf57 Temtamy syndrome CPA6 Epilepsy, familial temporal lobe, 5; Febrile seizures, familial, 11 CRH Autosomal dominant nocturnal frontal [asperbio.com]

Benign infantile epilepsy can be mimicked by focal cortical dysplasia. [neupsykey.com]

Progressive Myoclonic Epilepsy Type 7

dysplasia Isolated focal cortical dysplasia type I Isolated focal cortical dysplasia type II Ito hypomelanosis Jeavons syndrome Joubert syndrome Joubert syndrome and related [se-atlas.de]

dysplasia-focal epilepsy syndrome C12orf57 Temtamy syndrome CPA6 Epilepsy, familial temporal lobe, 5; Febrile seizures, familial, 11 CRH Autosomal dominant nocturnal frontal [asperbio.com]

dysplasia-focal epilepsy syndrome / Pitt-Hopkins-like syndrome 1 610042 FOXG1 Rett syndrome (congenital variant) 613454 KCNJ10 EAST/SESAME syndrome 612780 KCNJ11 Neonatal [impactgenetics.com]

Lissencephaly

Cobblestone lissencephaly (COB) previously designated as lissencephaly "type 2", is a brain malformation consisting of a complex cortical dysplasia with glioneuronal heterotopia [dnatesting.uchicago.edu]

[…] polymicrogyria and other cortical dysplasias. [ncbi.nlm.nih.gov]

Lissencephaly (agyria) is a cortical dysplasia associated with a disturbance in the migration of neocortical neurons. [ncbi.nlm.nih.gov]

Versive Seizure

Nobili et al. (2004) recently reported three patients with hypermotor seizures, symptomatic of temporobasal cortical dysplasia, where SEEG showed temporal lobe ictal onset [onlinelibrary.wiley.com]

According to the literature [ 21 ], focal cortical dysplasia type I is related to temporal lobe seizures [ 14, 19 ]. [alliedacademies.org]

According to the literature [21], focal cortical dysplasia type I is related to temporal lobe seizures [14,19]. [alliedacademies.org]