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39 Possible Causes for Cortical Thinning, EEG Generalized Slowing

  • Alzheimer Disease

    Na, Dae Ryong Kang and Sang Won Seo, Higher education affects accelerated cortical thinning in Alzheimer's disease: a 5-year preliminary longitudinal study, International[dx.doi.org] ., posterior cingulate, precuneus, and/or temporoparietal cortices) on FDG-PET, and (3) cortical thinning/gray matter loss in a specific anatomic distribution (i.e., lateral[ncbi.nlm.nih.gov] Dysexecutive versus amnesic phenotypes of very mild Alzheimer’s disease are associated with distinct clinical, genetic and cortical thinning characteristics.[doi.org]

  • Traumatic Brain Injury

    Blast-Exposed Veterans With Mild Traumatic Brain Injury Show Greater Frontal Cortical Thinning and Poorer Executive Functioning .[doi.org]

  • Hydrocephalus

    Fetuses who develop progressive ventricular enlargement and cortical thinning from hydrocephalus before 28 weeks may have irreversible damage by 32 weeks.[chop.edu] A CT scan showed severe dilation of the brain’s lateral ventricles, while an MRI scan revealed massive enlargement of the lateral third and fourth venricles, a very thin cortical[sciencedaily.com] Prenatal factors such as progression, degree of cortical mantle thinning to less than 1.5 cm and in utero duration of greater than four weeks are associated with a poor prognosis[chop.edu]

  • Unverricht-Lundborg Syndrome

    The EEG usually shows photosensitivity, abnormal slow background, generalized high-amplitude multispikes, 3- to 5-Hertz spike waves or polyspike and wave complexes.[epilepsy.com] Thus the progression of cortical thinning cannot be explained by age alone.[ajnr.org] […] syndrome. [6] The interictal EEG shows a generalized slow spike-wave pattern, further activated by drowsiness and sleep. [16] EEG findings progressive myoclonic epilepsy[emedicine.medscape.com]

  • Temporal Lobe Epilepsy

    Advanced neurophysiologic techniques such as EEG and magnetoencephalography source imaging can help to determine the area generating the initial and propagated interictal[ncbi.nlm.nih.gov] Stufflebeam , Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy , NeuroImage , 52 , 4 ,[doi.org] EEG showed focal slow waves and epileptic abnormalities on temporal regions in 1 patient and was normal in the other affected individuals.[diagenode.com]

  • West Syndrome

    EEG results indicated generalized slow activity. After she was diagnosed as having vitamin B(12) deficiency, parenteral treatment with vitamin B(12) was initiated.[ncbi.nlm.nih.gov] The MRI report found the evidence of cortical thinning and hyperintense signal on T2 WI, FLAIR and IR involving bilateral occipital poles.[doctor.ndtv.com] […] atrophy, thin CC AD 50% SCN1A AD 13% PLCB1 AR 2 cases TBC1D24 AR 1 family West syndrome TSC1/2 Tuberous sclerosis AD 20% (where onset of spasms without other prior seizures[rch.org.au]

  • Benign Familial Infantile Epilepsy

    Cognitive deficits Abnormal imaging in 2/3, cryptogenic in 1/3 EEG findings: Slow generalized spike-and-wave discharges (1-2 Hz) AEDs of choice: Valproate, clonazepam, ethosuximide[emilytam.com] […] atrophy, thin CC AD 50% SCN1A AD 13% PLCB1 AR 2 cases TBC1D24 AR 1 family West syndrome TSC1/2 Tuberous sclerosis AD 20% (where onset of spasms without other prior seizures[rch.org.au] Subsequent EEGs may show diffuse slowing and/or generalized discharges while other imaging remains normal.[rarediseases.org]

  • Autistic Disorder

    Scalp video-EEG recordings revealed an epileptic encephalopathy with generalized slow spike-and-wave complexes alternating with electrodecremental periods, which generally[ncbi.nlm.nih.gov] Abnormal neuronal migration leads to circumscribed foci of thin cortical areas in ASD human brain especially in frontal lobe containing smaller pyramidal neurons and interneurons[doi.org] Both nonspecific changes, such as slowing or asymmetry, and epileptiform discharges, consisting of spikes or sharp wave discharges, sharp slow waves, generalized spike-wave[doi.org]

  • Vascular Dementia

    Prominent posterior slow-wave activity on EEG with periodic fluctuations in the pre-alpha/ theta range.[indianjpsychiatry.org] thinning 41 and cortical atrophy, 42 which occurs 10 years before the onset of symptoms.[scielo.br] Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology. 2012;79(20):2025–8.[doi.org]

  • Persistent Vegetative State

    EEG findings included normal, continuous generalized slowing, intermittent generalized slowing, background slowing, background suppression, alpha, generalized periodic pattern[ncbi.nlm.nih.gov] MRI revealed large ventricles and thin bands of cortical tissue indicating laminar necrosis that particularly involved the posterior parietal and occipital regions.[dx.doi.org] EEG findings had no association with etiology and varied from one pattern to another in the same patients’ EEGs obtained at different times (see table).[journals.lww.com]

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