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14 Possible Causes for Cortical Thinning, Generalized Rhythmic Slowing

  • Alzheimer Disease

    Na, Dae Ryong Kang and Sang Won Seo, Higher education affects accelerated cortical thinning in Alzheimer's disease: a 5-year preliminary longitudinal study, International[dx.doi.org] ., posterior cingulate, precuneus, and/or temporoparietal cortices) on FDG-PET, and (3) cortical thinning/gray matter loss in a specific anatomic distribution (i.e., lateral[ncbi.nlm.nih.gov] Dysexecutive versus amnesic phenotypes of very mild Alzheimer’s disease are associated with distinct clinical, genetic and cortical thinning characteristics.[doi.org]

  • Traumatic Brain Injury

    Blast-Exposed Veterans With Mild Traumatic Brain Injury Show Greater Frontal Cortical Thinning and Poorer Executive Functioning .[doi.org]

  • Hydrocephalus

    Fetuses who develop progressive ventricular enlargement and cortical thinning from hydrocephalus before 28 weeks may have irreversible damage by 32 weeks.[chop.edu] A CT scan showed severe dilation of the brain’s lateral ventricles, while an MRI scan revealed massive enlargement of the lateral third and fourth venricles, a very thin cortical[sciencedaily.com] Prenatal factors such as progression, degree of cortical mantle thinning to less than 1.5 cm and in utero duration of greater than four weeks are associated with a poor prognosis[chop.edu]

  • Parkinson's Disease

    Other effective techniques to promote relaxation include slow rotational movements of the extremities and trunk, rhythmic initiation, diaphragmatic breathing, and meditation[en.wikipedia.org] thinning in patients with Parkinson’s disease longitudinally, Brain, 10.1093/brain/awu036, 137, 4, (1120-1129), (2014).[oadoi.org] In terms of improving flexibility and range of motion for people experiencing rigidity, generalized relaxation techniques such as gentle rocking have been found to decrease[en.wikipedia.org]

  • Benign Familial Infantile Epilepsy

    […] parasagittal theta 2.5-3Hz generalized spike or polyspike-wave discharges (myoclonus) interrupted by slow wave paroxysmal bursts (atonia) AEDs of choice: Valproate, levetiracetam[emilytam.com] […] atrophy, thin CC AD 50% SCN1A AD 13% PLCB1 AR 2 cases TBC1D24 AR 1 family West syndrome TSC1/2 Tuberous sclerosis AD 20% (where onset of spasms without other prior seizures[rch.org.au] Other abnormalities included unilateral rhythmic frontotemporal or parietotemporal SW and brief bursts of generalized spike waves (alone or in association with the above-mentioned[emedicine.medscape.com]

  • Benign Familial Neonatal Epilepsy

    Secondarily generalized rhythmic spike-wave activity ( C ), clinically accompanied by apnea and cyanosis is followed by generalized slowing of the background activity ( D[karger.com] […] atrophy, thin CC AD 50% SCN1A AD 13% PLCB1 AR 2 cases TBC1D24 AR 1 family West syndrome TSC1/2 Tuberous sclerosis AD 20% (where onset of spasms without other prior seizures[rch.org.au] […] paroxysmal exertional dystonia AD MECP2 Atypical Rett syndrome XD FOXG1 Atypical Rett syndrome AD Migrating focal seizures of infancy (MMPSI) KCNT1 Delayed myelination, cortical[rch.org.au]

  • West Syndrome

    Hypsarrhythmia represents a completely chaotic and disorganized background pattern consisting of high amplitude slow waves and spikes that are asynchronous, non-rhythmic,[web.archive.org] The MRI report found the evidence of cortical thinning and hyperintense signal on T2 WI, FLAIR and IR involving bilateral occipital poles.[doctor.ndtv.com] […] atrophy, thin CC AD 50% SCN1A AD 13% PLCB1 AR 2 cases TBC1D24 AR 1 family West syndrome TSC1/2 Tuberous sclerosis AD 20% (where onset of spasms without other prior seizures[rch.org.au]

  • Rolandic Epilepsy

    Other abnormalities included unilateral rhythmic frontotemporal or parietotemporal SW and brief bursts of generalized spike waves (alone or in association with the above-mentioned[emedicine.com] Backes, Early onset of cortical thinning in children with rolandic epilepsy, NeuroImage: Clinical, 2, (434), (2013). Tracy A.[doi.org] Early onset of cortical thinning in children with rolandic epilepsy.[frontiersin.org]

  • Anti-NMDA Receptor Encephalitis

    slowing or intermittent rhythmic delta activity on EEG, and some subcortical MRI abnormalities).[doi.org] 2008 , vol. 70 (pg. 504 - 11 ) Immunotherapy-responsive seizure-like episodes with potassium channel antibodies, Neurology, 2008 , vol. 71 (pg. 1647 - 8 ) Gyral and sulcal cortical[doi.org] […] lesions), and the later appearance of basal ganglia and brainstem-localised features (movement disorders, fall in level of consciousness, dysautonomia, CSF oligoclonal bands, generalized[doi.org]

  • Benign Familial Chorea

    Slow waves (3-6 Hz) can occur continually or in intermittent rhythmic paroxysms. They may be generalized or predominantly over the frontal and central regions.[emedicine.medscape.com] Skeletal survey may show thinning of the cortices of long bones with wormian bones in mild cases.[www2.le.ac.uk]

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