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17 Possible Causes for Cortical Thinning, Intermittent Slow Activity

  • Alzheimer Disease

    Na, Dae Ryong Kang and Sang Won Seo, Higher education affects accelerated cortical thinning in Alzheimer's disease: a 5-year preliminary longitudinal study, International[dx.doi.org] Dysexecutive versus amnesic phenotypes of very mild Alzheimer’s disease are associated with distinct clinical, genetic and cortical thinning characteristics.[doi.org] ., posterior cingulate, precuneus, and/or temporoparietal cortices) on FDG-PET, and (3) cortical thinning/gray matter loss in a specific anatomic distribution (i.e., lateral[ncbi.nlm.nih.gov]

  • Traumatic Brain Injury

    Blast-Exposed Veterans With Mild Traumatic Brain Injury Show Greater Frontal Cortical Thinning and Poorer Executive Functioning .[doi.org]

  • Hydrocephalus

    Fetuses who develop progressive ventricular enlargement and cortical thinning from hydrocephalus before 28 weeks may have irreversible damage by 32 weeks.[chop.edu] A CT scan showed severe dilation of the brain’s lateral ventricles, while an MRI scan revealed massive enlargement of the lateral third and fourth venricles, a very thin cortical[sciencedaily.com] Prenatal factors such as progression, degree of cortical mantle thinning to less than 1.5 cm and in utero duration of greater than four weeks are associated with a poor prognosis[chop.edu]

  • Unverricht-Lundborg Syndrome

    Thus the progression of cortical thinning cannot be explained by age alone.[ajnr.org] The interictal EEG showed frequent intermittent generalized theta slowing, but no clear-cut epileptiform activity.[frontiersin.org] In visual assessment of MR images, focal brain abnormalities were not found but cortical thickness analysis and texture analysis revealed subtle brain changes in patients[uef.fi]

  • Benign Familial Infantile Epilepsy Type 4

    […] atrophy, thin CC AD 50% SCN1A AD 13% PLCB1 AR 2 cases TBC1D24 AR 1 family West syndrome TSC1/2 Tuberous sclerosis AD 20% (where onset of spasms without other prior seizures[rch.org.au] EEG during the first years of life remained without clear epileptic discharges but showed slowing of background activity.[karger.com] The EEG examination showed normal background activity with a normal driving response to intermittent photic stimulation (IPS) (a).[onlinelibrary.wiley.com]

  • Progressive Myoclonic Epilepsy Type 3

    However, voxel-based morphometry may show cortical and thalamic atrophy and thinned cortical thickness in the sensorimotor areas.[ 9 ] [ 10 ] Abnormalities in the EEG (background[thieme-connect.com] Cranial CT yielded normal results; EEG revealed overall slowing of the background activity plus some diffuse spike-wave complexes.[elsevier.es] The EEG showed slow background activity with generalised epileptiform discharges manifesting as spike/polyspike wave complexes of variable duration that persisted throughout[elsevier.es]

  • Neuronal Ceroid Lipofuscinosis

    In the first, subjects with CLN2 exhibited differing rates of cortical thinning versus age.[ncbi.nlm.nih.gov] EEG showed slow background with IRDA (intermittent rhythmic delta activity).[ncbi.nlm.nih.gov] Therefore, cortical thinning in the GFAP / Vim / PPT1 / brains was more severe than in the PPT1 / or GFAP / Vim / brains.[jneurosci.org]

  • Progressive Supranuclear Palsy

    Relative to controls, PSPs patients had a focal, bilateral cortical thinning mainly located in the prefrontal/precentral cortex and temporal pole.[ncbi.nlm.nih.gov] On examination, she had vertical upgaze palsy and downgaze slowing, intermittent myoclonic jerks of the hand and mild symmetrical bradykinesia with axial rigidity.[doi.org] A further SPECT showed widespread hypoperfusion of the cerebral cortex, with thinning of the cortical thickness.[dovepress.com]

  • Alpers Syndrome

    The brain MR imaging was remarkable for diffuse cerebral atrophy, considerable decrease in white matter and cortical thinning of the frontal, posterior temporal and occipital[pjms.com.pk] The patterns of EEG seen in are highly variable and may include high amplitude slow activity or intermittent continuous spike-wave activity.[symptoma.com] These include diminished white matter and cortical thinning of the frontal posterotemporal and occipital lobes. 9 Lesions of the thalamus also have been reported. 10 The cases[pjms.com.pk]

  • Persistent Vegetative State

    MRI revealed large ventricles and thin bands of cortical tissue indicating laminar necrosis that particularly involved the posterior parietal and occipital regions.[dx.doi.org]

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