Cortical Tubers: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Cortical Tubers

Tuberous Sclerosis

Early appearance of cortical tubers on cerebral ultrasound in newborn infants is very rare. Mostly TSC is diagnosed on MRI and not by cerebral ultrasound. [ncbi.nlm.nih.gov]

The multiple cortical tubers cause multiple or wide epileptic networks in these cases. [ncbi.nlm.nih.gov]

KEYWORDS: Cortical tuber; Epilepsy; Focal cortical dysplasia; Hippocampal sclerosis; Tuberous sclerosis [ncbi.nlm.nih.gov]

Tuberous Sclerosis Type 2

Until now cortical tubers have been neglected in this respect. [journals.plos.org]

Ultrastructure of tuberous sclerosis: cortical tuber and subependymal tumor. Ann Neurol, 9 (1981), pp. 174-181 [6] M. Mizuguchi, S. Takashima. [elsevier.es]

Two types of lesions are static (hamartias) ; cortical tubers, and subcortical heterotopic nodules, whereas subependymal nodules are often progressive (hamartoma), hence the [atlasgeneticsoncology.org]

Tuberous Sclerosis Type 1

ASD severity and cortical tubers  N=52, 2-17 years, 46.2% boys  Cortical tuber count  MRI • Total • Per lobe  ASD severity  ADOS (calibrated severity scores) • Total [slideshare.net]

The presence of both white matter radial migration lines and cortical tubers is also counted only once. [path.upmc.edu]

Subependymal Giant Cell Astrocytoma

CONCLUSION: This is the first description of cortical tubers harboring SEGA tissue. [ncbi.nlm.nih.gov]

[…] analysis of cortical tubers and perituberal cortex. [springermedizin.de]

GS expression and mTOR pathway activation were also documented in cortical tubers. [ncbi.nlm.nih.gov]

Rhabdomyoma of the Myocardium

tubers Hypomelanotic maculae No Negative Multiple thabdomyomas Mental retardation Subependymal nodule 15 Heart murmur West syndrome Cortical tubers Hypomelanotic maculae [bmccardiovascdisord.biomedcentral.com]

The definitive diagnosis was confirmed at autopsy, which showed multiple macroscopic and microscopic rhabdomyomas in the myocardium, associated with multifocal cortical tubers [circ.ahajournals.org]

A 7 year old male with a history of a seizure disorder and developmental delay is found to have cortical tubers on brain magnetic resonance imaging. [healio.com]

Hamartoma of the Central Nervous System

Cortical tubers Tuberous sclerosis. Cortical lesions (tubers). The lesions are firm, and cortical/white matter demarcation is lost. Compare to adjacent normal cortex. [neuropathology-web.org]

tubers), subependymal nodules, subependymal giant cell astrocytomas -Mass effect symptoms, such as hydrocephalus and papilledema -Seizures or infantile spasms. [pedclerk.bsd.uchicago.edu]

Cortical blindness as severe neuro-ophthalmological manifestation of tuberous sclerosis complex Case Report Abstract Patients with retinal lesions related to tuberous sclerous [egms.de]

Subungual Fibroma

Additional Evaluative Tests CT or MRI of the head should be considered for cortical tubers or other clinically occult manifestations of TSC. [thelamfoundation.org]

Usually begins in infancy or early childhood and may precede appearance of skin lesions by years The greater the number of tumours (cortical tubers) in the brain, the greater [dermnetnz.org]

[…] sclerosis are as follows: Brain: Cortical tuber Retina : Phakomas Skin : Angiofibroma Heart : Rhabdomyoma Bone : Sclerotic lesions Lung : Lymphangioma Kidney: Angiomyolipoma [journals.publishmed.com]

Fibrillary Astrocytoma

We present the clinical, computed tomography and magnetic resonance imaging findings of a fibrillary astrocytoma originating from a cortical tuber in a 4-year-old female with [ncbi.nlm.nih.gov]

Mizuguchi M, Takashima S, Yamanouchi H, Nakazato Y, Mitani H, Hino O: Novel cerebral lesions in the Eker rat model of tuberous sclerosis: Cortical tuber and anaplastic ganglioglioma [karger.com]

Although giant cell astrocytoma may develop from these subependymal nodules, tumor formation is very rare in the cortical nodules. [ncbi.nlm.nih.gov]

Absence of Septum Pellucidum

[…] hamartomas of tuberous sclerosis hemimegalencephaly focal cortical dysplasia (Type I and Type IIb) Palmini classification (2004) Barkovich classification (2005) Blumcke classification [radiopaedia.org]

[…] pattern microcephaly with lissencephaly microcephaly with extensive polymicrogyria macrocephalies (megalencephaly/macrocephaly) abnormal cell proliferation non-neoplastic cortical [radiopaedia.org]

Malformations of the central nervous system malformations of cortical development abnormal cell proliferation or apoptosis abnormal brain size microcephaly with normal to simplified cortical [radiopaedia.org]

Complex Cortical Dysplasia with other Brain Malformations Type 3

Until now cortical tubers have been neglected in this respect. [journals.plos.org]

HPV16 E6 protein was expressed in all FCDIIB specimens in balloon cells (BC), but not in regions without BCs or control tissue including normal brain and cortical tubers. [pediatricneurologybriefs.com]

Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol. 2001;49:67–78. 15. [j-epilepsy.org]

Complex Cortical Dysplasia with other Brain Malformations Type 4

Until now cortical tubers have been neglected in this respect. [journals.plos.org]

Cortical blindness as severe neuro-ophthalmological manifestation of tuberous sclerosis complex Case Report Abstract Patients with retinal lesions related to tuberous sclerous [egms.de]

Non-neoplastic cortical hamartomas of tuberous sclerosis cortical dysplasia with balloon cells hemimegalencephaly type II focal cortical dysplasia Neoplastic gangliogliomas [radiopaedia.org]

Complex Cortical Dysplasia with other Brain Malformations Type 2

Until now cortical tubers have been neglected in this respect. [journals.plos.org]

Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol. 2001;49:67–78. 15. [j-epilepsy.org]

Non-neoplastic cortical hamartomas of tuberous sclerosis cortical dysplasia with balloon cells hemimegalencephaly type II focal cortical dysplasia Neoplastic gangliogliomas [radiopaedia.org]

Complex Cortical Dysplasia with Other Brain Malformations Type 5

Until now cortical tubers have been neglected in this respect. [journals.plos.org]

Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol. 2001;49:67–78. 15. [j-epilepsy.org]

Tubers typically appear as areas of increased signal intensity in the cortical and subcortical regions on T2-weighted and fluid attenuated inversion recovery MRI. [jdrntruhs.org]

Enamel Hypoplasia - Cataracts - Aqueductal Stenosis

Consequently, there is cortical malformations, including tubers, focal cortical dysplasia type IIb, ganglioglioma, and hemimegalencephaly Tuberous sclerosis is characterized [sites.google.com]

Cortical tubers generally form on the surface of the brain and can lead to various neurologic symptoms depending on location. Renal. [healio.com]

Neuropathological lesions of TSC include subependymal nodules (SENs), cortical and subcortical hamartomas (tubers), areas of focal cortical hypoplasia, and heterotopic gray [clinicalgate.com]

Hippus

tubers. [onlinelibrary.wiley.com]

tubers ( Fig. 2 ). [onlinelibrary.wiley.com]

[…] sagittal T 2 ‐fluid‐attenuated inversion recovery (FLAIR): Multiple ill‐defined areas of hyperintense signal in T 2 ‐FLAIR sequence suggested the radiologic diagnosis of cortical [onlinelibrary.wiley.com]

Angiomyolipoma

[…] sclerosis include facial angiofibromas, cortical tubers, subependmal nodules, giant cell astrocytomas, cardiac rhabdomyomas, lymphagniomyomatosis, and renal angiomyolipomas [appliedradiology.com]

MRI revealed multiple T2 hyperintense cortical tubers (Figure 3B). [oatext.com]

The classic triad of tuberous sclerosis consists of adenoma sebaceum, seizures, and mental retardation, but is only seen in one-third of patients.Major features of tuberous [appliedradiology.com]

Hereditary Neurocutaneous Angioma

cortical tuber. [thamburaj.com]

Sclerosis (Bourneville's Disease)” Tuberous Sclerosis In our body, the cortical development malformation, Tuberous Sclerosis, aka Bourneville-Pringle disease, is a phakomatosis [wellnessadvocate.com]

Neuropathological lesions of TSC include subependymal nodules (SENs), cortical and subcortical hamartomas (tubers), areas of focal cortical hypoplasia, and heterotopic gray [neupsykey.com]

Renal Angiomyolipoma

MRI revealed multiple T2 hyperintense cortical tubers (Figure 3B). [oatext.com]

Other intracranial growths such as subependymal astrocytomas and cortical tubers are evidence of CNS involvement that can interfere with brain function leading to seizures [disorders.eyes.arizona.edu]

Northern Epilepsy

tubers) are absent. [clinicaladvisor.com]

On magnetic resonance imaging the typical features of sub-ependymal tubers (fig 2), cortical tubers, and giant cell astrocytoma can be readily visualised. [jnnp.bmj.com]

Underlying pathologies in these cases may include the following: Encephalitis and/or meningitis Tuberous sclerosis Brain malformations (eg, cortical dysplasias) Hypoxia-ischemia [emedicine.medscape.com]

Anaplastic Ganglioglioma

Cortical tuber. Trapped cortical neurons in diffuse astrocytoma. Papillary glioneuronal tumor. See also Neuropathology tumours. Pilocytic Astrocytoma. [librepathology.org]

[…] sclerosis: cortical tuber and anaplastic ganglioglioma. ( 10744057 ) Mizuguchi M....Hino O. 2000 30 Extracranial metastasis of anaplastic ganglioglioma through a ventriculoperitoneal [malacards.org]

[…] immunohistochemical study and molecular analysis of p53 tumor suppressor gene. ( 12030414 ) Suzuki H....Takei H. 2002 29 Novel cerebral lesions in the Eker rat model of tuberous [malacards.org]

Hemimegalencephaly

The white-matter lesions were better seen in the neonatal period, whereas cortical tubers were better detected at a later age. [ncbi.nlm.nih.gov]

Within this classification based on histological and morphological criteria, HME find itself in the same group as the cortical harmatomas of Tuberous Sclerosis Complex (TSC [epilepsygenetics.net]

We describe two children with complex cortical malformations as well as the typical intracranial manifestations of tuberous sclerosis complex. [ncbi.nlm.nih.gov]

Joubert Syndrome Type 14

Benign Tumors of the Eye, Heart, and Lungs

The most common are cortical tubers, subependymal giant cell astrocytomas (SEGAs) and subependymal nodules. [childrenshospital.org]

cortical/subcortical tubers. [2] The tubers are typically triangular in configuration, with the apex pointed towards the ventricles, and are thought to represent foci of [en.wikipedia.org]

Brain involvement in TSC Three types of brain lesions are seen in TSC: cortical tubers, for which the disease is named, generally form on the surface of the brain but may [ninds.nih.gov]

Renal Fibroma

Cortical tuber. Subependymal nodule (SEN). Subependymal giant cell astrocytoma (SEGA). Cardiac rhabdomyoma, single or multiple. [patient.info]

tuber Non-renal hamartoma Subependymal nodule Retinal achromatic patch SGCT(subependymal giant cell tumour) Confetti skin lesions Cardiac rhabdomyomas, single or multiple [academic.oup.com]

Joubert Syndrome Type 20

Childhood-Onset Idiopathic Basal Ganglia Calcification

The term 'tuberous sclerosis,' which was coined by Bourneville (1880), refers to one of the characteristic lesions of the disease, i.e., cortical brain tubers that subsequently [rrnursingschool.biz]

Fascial Plaques, Ungual Fibroma), brain (Cortical Tubers, Subependymal Nodules, seizures, Intellectual disability/development delay), kidney (Angiolipoma, cysts) and heart [ojrd.biomedcentral.com]

[…] plaques, ungual fibromas), brain (cortical tubers, subependymal nodules, seizures, mental retardation/developmental delay), kidney (angiomyolipomas, cysts), and heart (rhabdomyomas [canglish1.tripod.com]

Dyschromatosis Universalis Hereditaria Type 1

Cortical tuber 7. Subependymal nodule 8. Subependymal giant cell astrocytoma 9. Cardiac rhabdomyoma, single or multiple 10. Lymphangiomyomatosis 11. [ijdvl.com]

Cerebellar Vermis Aplasia with Associated Features Suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome

cortical/subcortical tubers. [2] The tubers are typically triangular in configuration, with the apex pointed towards the ventricles, and are thought to represent foci of [en.wikipedia.org]

tubers, subependymal nodules, giant cell astrocytoma, cardiac rhabdomyoma, lymphangiomyomatosis, lymph node angiomyolipoma. [hawaii.edu]

Subependymal tumors and cortical tubers are the two characteristic neurologic features of TSC. [slideshare.net]

Sacrococcygeal Dysgenesis Association

tuber... ‏ [books.google.com]

[…] forehead plaque Nontraumatic ungual or periungual fibroma Hypomelanotic macules (three or more) Shagreen patch (connective tissue nevus) Multiple retinal nodular hamartomas Cortical [books.google.com]

Infantile Choroidocerebral Calcification Syndrome

tubers. [appliedradiology.com]

Similar to cortical tuber. [radnotes.co.nz]

The ensuing anomalies of neuronal proliferation and differentiation result in varied expression of hamartomas in the brain—referred to as subependymal nodules and cortical [appliedradiology.com]