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177 Possible Causes for Cortisol Increased, Cushing's Disease, Gynecomastia

  • Chronic Alcoholism

    ENDOCRINE – Cirrhosis leading to gynecomastia and testicular atrophy, amenorrhea/infertility. Alcohol can also cause hypoglycemia in alcoholics.[] Osteoporosis increases the risk of fractures, especially in the proximal femur of the hip.[] Alcoholic Liver Disease Physical Examination Constitutional Fever Skin Spider angioma Parotid and lacrimal gland enlargement Palmer erythema Jaundice Decreased body hair Gynecomastia[]

  • Pituitary Neoplasm

    Tumor-dependent symptoms seen in pituitary adenomas include: Amenorrhea, galactorrhea, gynecomastia, and infertility in the case of prolactinoma.[] , due both to the estrogen-induced increase in cortisol binding globulin (CBG) levels and an increase in cortisol production.[] A 52-year-old woman developed recurrent hypercortisolism 3 yr after successful surgical treatment of Cushing's disease.[]

  • Adrenocortical Carcinoma

    We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia.[] From the 24-h urine collection sample, urine aldosterone and urine cortisol levels were greatly increased.[] This was suggestive of primary adrenal disease as cortisol levels normally suppress to less than 50% of basal levels in pituitary driven Cushing’s disease.[]

  • Cushing's Disease

    In the corticotropin-releasing hormone (CRH) test, ACTH and cortisol increased only by 28%.[] If Cushing's disease remains untreated it may be fatal.[] We have also shown that the paradoxical increase in serum cortisol was preceded by a paradoxical increase in ACTH.[]

  • Adrenal Cortical Adenoma

    A physical exam may reveal central obesity, hirsutism, striae, and gynecomastia. An ophthalmologic exam may reveal retinopathy secondary to chronic hypertension.[] These androgen secreting tumours frequently present in women with increased facial hair growth (hirsutism), irregular periods and infertility sometimes with masculinization[] The adrenal tissue of patients with Cushing's disease was predominantly yellow.[]

  • Obesity

    Some of the endocrine changes associated with protein-energy malnutrition, such as decreased plasma IGF-1 levels, increased plasma cortisol and a relative reduction in plasma[] Exclusion criteria were coronary heart disease; type 1 or type 2 diabetes; renal, liver, or respiratory failure; gout; obesity with known cause (Cushing's disease, hypothyroidism[] Taylor, Low Calorie Dieting Increases Cortisol, Psychosomatic Medicine, 72, 4, (357), (2010). Jung Sun Lee, Joan G.[]

  • Pituitary Adenoma

    […] can cause reduced testosterone production and the most common symptoms of prolactinomas in men are erectile dysfunction, decreased libido, enlargement of breast tissue (gynecomastia[] F 36 24 Increased cortisol, 24 h urinary cortisol, dexamethasone suppression test 12 Patient no.[] However, it is very rare that acromegaly shows subclinical Cushing's disease (SCD) beyond the lineage.[]

  • Paraneoplastic Syndrome

    Pathology: Loss of Purkinje cells Yo antibody syndrome Yo staining Cerebellar Purkinje cell Epidemiology: Most common in Sex Female ( 95%) Male: 3 patients reported, 2 with gynecomastia[] Endocrine: SIADH  Syndrome of inappropriate ADH (secretion)  1. insertion of aquaporin-2 in apical membrane in distal tubule: increased water absorption  2.[] Medical therapy of Cushing's disease. Pituitary. 2002; 5 :77-82 [ PubMed ] [ Google Scholar ] 15. Nayar MK, Lombard MG, Furlong NJ, McNulty SJ, Hardy KJ, Vora J.[]

  • Small Cell Carcinoma of the Lung

    This can lead to weight gain, weakness, diabetes, increased body and facial hair, and thin or darkened skin (Cushing’s syndrome).[] In rare cases, carcinoid lung tumors may produce too much ACTH, a substance that causes the adrenal glands to make too much cortisol and other hormones.[]

  • Adrenal Cushing Syndrome

    […] adenomas and carcinomas Virilization: in females-male pattern baldness, clitoromegaly and deepening of voice Feminization: in males-loss of libido, testicular atrophy and gynecomastia[] Increased cortisol levels send a signal to the pituitary gland to decrease ACTH secretion, in order to maintain cortisol at normal levels.[] KEYWORDS: Adrenal insufficiency; Adrenocortical adenoma; Cushing disease; Cushing syndrome[]

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