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134 Possible Causes for COX Negative Fibers

  • Progressive External Ophthalmoplegia - Myopathy - Emaciation Syndrome

    Ragged- red fibers are mostly COX negative, but svme (arrow) are strongly posittoe.[documents.tips] D), respectively. reveul marked decrease in the number of ragged-red fibers and increase in iyto- chrome c oxidase (GOXI uctivity in the second biopsy.[documents.tips]

  • Myopathy

    COX-negative fibers Mitochondrial myopathy. COX-negative fibers. Mitochondria in RRF Mitochondrial myopathy. Abnormal mitochondria.[neuropathology-web.org] Small numbers of COX-negative fibers are also seen in inflammatory myopathies, especially inclusion body myositis, and in old people without muscle disease.[neuropathology-web.org] In addition,in some mitochondrial myopathies, especially CPEO, KSS, and MERRF, the muscle contains Cytochrome C Oxidase-negative fibers .[neuropathology-web.org]

  • Mitochondrial Neurogastrointestinal Encephalomyopathy Type 4B

    The peroneus brevis showed neurogenic atrophy, and slight lipid accumulation in type 2 fibers without RRF and COX negative fibers.[em-consulte.com] COX-negative fibers Mitochondrial myopathy. COX-negative fibers. Abnormal mitochondria in RRF Mitochondrial proliferation in a ragged red fiber.[neuropathology-web.org] EM of the deltoid muscle biopsy showed one ragged red fiber (RRF), a few cytochrome oxydase (COX) negative fibers and moderate lipid storage in type 2 fibers with no mitochondrial[em-consulte.com]

  • Myositis

    fibers.[orpha.net] […] stains Rarely, cytochrome oxidase / COX negative fibers are seen Electron microscopy description Molecular / cytogenetics description Differential diagnosis Amyotrophic lateral[pathologyoutlines.com] There are an increased number of ragged red fibers and COX negative fibers. Some nuclei containing eosinophilic inclusions appear to be enlarged within the vacuoles.[ncbi.nlm.nih.gov]

  • Autoimmune Polyendocrinopathy

    Single-muscle fiber analysis showed significantly higher levels of both the mutations in COX-negative than in normal fibers.[ncbi.nlm.nih.gov] Muscle biopsy shows abundant COX-negative fibers, subsarcolemmal mitochondrial aggregates and markedly reduced activities of all respiratory chain complexes.[ncbi.nlm.nih.gov] Genetic analysis identified two new cosegregating mutations in Met-tRNA (m.4415A G) and Cox III (m.9922A C), located in highly conserved regions of MtDNA.[ncbi.nlm.nih.gov]

  • Myopathy and Diabetes mellitus

    Ragged-red and cytochrome c oxidase (COX)-negative fibers were present in muscle biopsies.[ncbi.nlm.nih.gov]

  • Mitochondrial Myopathy

    Analysis of single muscle fibers revealed a significantly higher level of mutated mtDNA in COX-negative fibers.[ncbi.nlm.nih.gov] […] and endomysial fibrosis) and mitochondrial alterations [ragged-red, cytochrome c oxidase (COX)-negative fibers].[ncbi.nlm.nih.gov] Muscle biopsy showed ragged-red and COX-negative fibers associated with discrete inflammatory infiltrates and necrotizing features.[ncbi.nlm.nih.gov]

  • MERRF Syndrome

    Single-fiber PCR analysis showed that the proportion of mutant genomes was higher in cytochrome c oxidase (COX)-negative ragged red fibers (RRFs) than in COX-positive non-RRFs[ncbi.nlm.nih.gov] Muscle biopsy of the proband showed abnormal mitochondrial proliferation and COX-negative fibers.[omim.org] Skeletal muscle biopsy showed multiple COX-negative fibers and ragged red fibers. Genetic analysis identified a heteroplasmic mutation in the MTTF gene (590070.0002).[omim.org]

  • Vacuolar Neuromyopathy

    COX-negative fibers Mitochondrial myopathy. COX-negative fibers. Mitochondria in RRF Mitochondrial myopathy. Abnormal mitochondria.[neuropathology-web.org] Small numbers of COX-negative fibers are also seen in inflammatory myopathies, especially inclusion body myositis, and in old people without muscle disease.[neuropathology-web.org] In addition,in some mitochondrial myopathies, especially CPEO, KSS, and MERRF, the muscle contains Cytochrome C Oxidase-negative fibers .[neuropathology-web.org]

  • Cerivastatin

    Muscle histochemistry revealed ragged-red fibers and cytochrome c oxidase negative (COX) fibers, and biochemistry showed a defect of COX activity.[ncbi.nlm.nih.gov]

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