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784 Possible Causes for Cranial Nerve Involvement, Paraplegia

  • Multiple Sclerosis

    Pelizaeus-Merzbacher disease and spastic paraplegia type 2 are allelic X-linked disorders associated with defective myelination of the central nervous system and mutations[] Examples of common clinical features include 23,24 : brainstem and cranial nerve involvement: optic neuritis internuclear ophthalmoplegia (often bilateral) trigeminal neuralgia[] […] societies: Alpha Omega Alpha , American Academy of Physical Medicine and Rehabilitation , American Association of Neuromuscular and Electrodiagnostic Medicine , American Paraplegia[]

  • Syringomyelia

    A 40-year-old man with complete paraplegia since 1991 as a consequence of a Th4 vertebral fracture showed a great posttraumatic syringomyelia that extended up to C2 vertebral[] Spastic paraparesis: Legs Arms Skeletal Scoliosis Cranial nerve involvement: With syringobulbia Most often unilateral XII: Tongue weakness & hemiatrophy IX - X: Dysphagia[] […] for rapid progression of curve; - left thoracic scoliosis is common; - treatment of the scoliosis without recognition of syringomyelia and Chiari malformation can lead to paraplegia[]

  • Amyotrophic Lateral Sclerosis

    The most common form of autosomal recessive hereditary spastic paraplegia is caused by mutations in the SPG11/KIAA1840 gene on chromosome 15q.[] Diagnosis Electrodiagnostic tests MRI of the brain and, if no cranial nerve involvement, cervical spine Laboratory tests to check for other, treatable causes Diagnosis of[] Pathogenic mutations in the KIF5A-SPG10 gene, encoding the kinesin HC5A, can be associated with autosomal dominant hereditary spastic paraplegia (ADHSP).[]

  • Meningitis

    Without early surgery, patients can develop severe kyphosis leading to respiratory insufficiency, painful costopelvic impingement and paraplegia.[] Multiple cranial nerve involvement may be associated with basal meningeal involvement as seen in carcinomatous meningitis and sarcoidosis.[] Some pachymeningitis are cranial and induce headaches and cranial nerve palsies. Others are spinal and responsible for nerve roots or spinal cord compression.[]

  • Primary Progressive Multiple Sclerosis

    […] patients and presents with optic neuritis and other isolated spinal cord/brainstem abnormalities, the clinical presentation of PPMS is comprised of two main symptoms - spastic paraplegia[] Examples of common clinical features include 23,24 : brainstem and cranial nerve involvement: optic neuritis internuclear ophthalmoplegia (often bilateral) trigeminal neuralgia[] It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia[]

  • Systemic Lupus Erythematosus

    RESPIRATORY: infections and PE’s, pleuralitis, pleural effusion, pulmonary fibrosis NEUROLOGICAL: cranial and peripheral nerve lesions, transverse myelitis - weakness and paraplegia[] She was positive for anti-aquaporin-4 (AQP4) antibody and had typical cranial and longitudinally extended spinal lesions but no optic nerve involvement.[]

  • Meningococcal Meningitis

    He responded well to antibiotics but was not investigated for causes of paraplegia. While at home in a rural area, he developed pressure ulcers, anemia and depression.[] nerve involvement and abnormal pupils).[] A 29 year old male developed paraplegia during the acute phase of meningococcal meningitis.[]

  • Tick Paralysis

    He presented flaccid paraplegia and arreflexia that progressed until causing dyspnea. The clinical symptoms subsided 48 h after the ticks spontaneously detached.[] If the tick continues to feed, the weakness ascends to the upper extremities over a matter of hours, followed by cranial nerve involvement.[] Early cranial nerve involvement is a feature, particularly the presence of both internal and external ophthalmoplegia.[]

  • Epidermal Nevus Syndrome

    We report a case of a patient with diagnosed ENS without any primary CNS lesions, who developed paraplegia resulting from spinal cord hemorrhage.[] , convergence, and 3rd, 4th, and 6th cranial nerve involvement. ‎[] Six months later, she developed flaccid paraplegia, followed by an intrathoracic angioma and angiomas of the C7 and T5 vertebrae.[]

  • Mycosis Fungoides

    Deafness from eighth cranial nerve involvement in a patient with large-cell transformation of mycosis fungoides. Eur J Haematol 2000 ; 64 : 340 –343 Grew JP.[] We report a case with changes in the midbrain and pons in a patient in whom cranial nerve signs developed 2 years after the initial diagnosis of mycosis fungoides (MF), in[] Chua et al ( 9 ) reported eighth cranial nerve deficits that caused deafness in a patient in whom CT and MR imaging findings were negative but in whom CSF findings revealed[]

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