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15 Possible Causes for Craniosynostosis, Sleep Apnea, Wide Space Between the First and Second Toe

  • Down Syndrome

    Boyadjiev, Genetic advances in craniosynostosis, American Journal of Medical Genetics Part A, 173, 5, (1406-1429), (2017) ., Practice Bulletin No. 187, Obstetrics & Gynecology[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Obstructive sleep apnea (OSA) is more common in children with Down syndrome, affecting up to 60% of patients, and may persist in up to 50% of patients after adenotonsillectomy[ncbi.nlm.nih.gov]

  • Dubowitz Syndrome

    A "new" clinical subtype is defined, which also includes anorectal anomalies and premature craniosynostosis.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Severe obstructive sleep apnea in a patient with spinal muscle atrophy. Chest . 2004 Nov. 126(5):1705-7. [Medline] . [Full Text] . Yasuma F, Kuru S, Konagaya M.[emedicine.medscape.com]

  • Craniofrontonasal Dysplasia

    Affected females had hypertelorism, broad nasal root, frontal bossing, craniosynostosis, syndactyly of toes and fingers, and vertical grooving of nails.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The patient’s initial symptoms included frequent headaches, history of obstructive sleep apnea, and abnormal head shape.[ncbi.nlm.nih.gov]

  • Kleiner Holmes Syndrome

    Learn more Other less relevant matches: Low match CRANIOSYNOSTOSIS 1; CRS1 Craniosynostosis is a primary abnormality of skull growth involving premature fusion of the cranial[mendelian.co] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic[books.google.de]

  • Atelosteogenesis Type 2

    Crouzon-like craniosynostosis with acanthosis nigricans Craniosynostosis (Muenke type) Antley-Bixler syndrome Craniosynostosis (Boston type) Saethre-Chotzen syndrome Shprintzen-Goldberg[emedicine.medscape.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] or commonly referred to as Sleep Apnea. 18. frequent respiratory infections 19. frequent ear infections. 20. connective tissue disorder 21. dislocation of the shoulders 22[tawnymullins77.blogspot.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    […] syndrome,” and (c) simple or single craniosynostosis.[entokey.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Syndromic craniosynostosis (20 percent) such as Crouzon, Apert, Pfeiffer, Muenke and Saethre-Chotzen syndrome occur due to mutations in the FGFR2, FGFR2, FGFR1 FGFR3, and[reviewofophthalmology.com]

  • Multiple Endocrine Neoplasia Type 2B

    […] with myopathy; gastrointestinal complaints, especially constipation; symptoms derived from medullary carcinoma of the thyroid ; symptoms derived from pheochromocytoma ; craniosynostosis[en.wikipedia.org] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com] Narrowing of the airway causes frequent upper respiratory infections and short pauses in breathing during sleep (sleep apnea).[ghr.nlm.nih.gov]

  • Greenberg Dysplasia

    1 CRS1 123100 Genetic Test Registry Craniosynostosis 2 Craniosynostosis, Boston-Type CRS2 CSB 604757 Genetic Test Registry Craniosynostosis 5, Susceptibility To CRS5 615529[ukgtn.nhs.uk] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] apnea, profound hypotonia, motor delay or excessive sweating, and can awake from sleep with emesis.[nature.com]

  • Trisomy 10p

    Med Klin (1968) 0.76 Studies of malformation syndromes of man XXXIX: a craniosynostosis-craniofacial dysostosis syndrome with mental retardation and other malformations: "[pubrank.carbocation.com] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com] Craniosynostosis with syndactyly. Aplasia Cutis Congenita.[neurometplus.com]

  • MORM Syndrome

    Every year we care for more than 150 children with craniosynostosis syndromes , including Apert.[seattlechildrens.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] "Interactions Between Obesity and Obstructive Sleep Apnea" . Chest . 137 (3): 711–719. doi : 10.1378/chest.09-0360 . PMC 3021364 .[en.wikipedia.org]

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