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18 Possible Causes for Craniosynostosis, Umbilical Hernia, Wide Space Between the First and Second Toe

  • Down Syndrome

    Boyadjiev, Genetic advances in craniosynostosis, American Journal of Medical Genetics Part A, 173, 5, (1406-1429), (2017) ., Practice Bulletin No. 187, Obstetrics & Gynecology[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

  • Craniofrontonasal Dysplasia

    hernia Abnormality of the breast Aplasia / Hypoplasia of the nipples Unilateral breast hypoplasia Abnormality of the digestive system Umbilical hernia Abnormality of the[familydiagnosis.com] Affected females had hypertelorism, broad nasal root, frontal bossing, craniosynostosis, syndactyly of toes and fingers, and vertical grooving of nails.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Dubowitz Syndrome

    His abdomen was obese with striae and a small midline umbilical hernia. His hands were short with tapered fingers; his nails appeared normal.[journals.plos.org] A "new" clinical subtype is defined, which also includes anorectal anomalies and premature craniosynostosis.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Cutis Laxa

    hernia.[healthceo.blogspot.com] , MEGF8, MSX2, POR, RAB23, RECQL4, SKI, SLC25A24, TCF12, TGFBR1, TGFBR2, TWIST1, WDR19, WDR35, ZIC1 Del Dup NGS Craniosynostosis, type 1 TWIST1 Sanger Del Dup NGS Crouzon[ctgt.net] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Atelosteogenesis Type 2

    Posterior helical ear pits, abdominal wall defects including umbilical hernia, and renal anomalies. Neonatal hypoglycemia and history of hydramnios and prematurity.[musculoskeletalkey.com] Crouzon-like craniosynostosis with acanthosis nigricans Craniosynostosis (Muenke type) Antley-Bixler syndrome Craniosynostosis (Boston type) Saethre-Chotzen syndrome Shprintzen-Goldberg[emedicine.medscape.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Genee-Wiedemann Syndrome

    Congenital umbilical hernia is common.[mun-h-center.se] […] microtia, skin tags, significant developmental delay, cleft palate EFTUD2 gene on chromosome 17q21 Baller Gerold syndrome (OMIM# 218600) Abnormally shaped skull, coronal craniosynostosis[gynecology-obstetrics.imedpub.com] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com]

  • Adactyly of Foot

    Imperforate Anus Pilonidal Cysts Preauricular Cysts Skin Lesions Requiring Surgery Soft Tissue Tumors – Cysts –Hemangiomas – (non-cancerous) Tracheoesophageal Fistula Umbilical[shrinerschildrens.org] Other skeletal anomalies (craniosynostosis, syndactyly, brachydactyly, oligodactyly and ectrodactyly) may also be present.[dysnet.org] Synonyms:Anterior Polydactyly Replaces: Anterior Duplication of the Limb, Tibial Polydactyly Foot, Preaxial Polydactyly of Subjective: A widely spaced gap between the first[quizlet.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    hernia, preauricular skin tags, and supernumerary teeth.[entokey.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Associated features include a hoarse cry,umbilical hernia, dry and cold extremities, myxedema, mottledskin, and mental retardation.[quizlet.com]

  • Nicolaides-Baraitser Syndrome

    During examination, it was found that the patient had an umbilical hernia [Figure 3].[ijpd.in] 2 Craniosynostosis Mental Retardation Clefting Syndrome Craniosynostosis, Adelaide Type Craniosynostosis, Calcification of Basal Ganglia, and Facial Dysmorphism Craniosynostosis-Mental[rgd.mcw.edu] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Multiple Endocrine Neoplasia Type 2B

    hernia ) or lower abdomen (inguinal hernia).[ghr.nlm.nih.gov] […] with myopathy; gastrointestinal complaints, especially constipation; symptoms derived from medullary carcinoma of the thyroid ; symptoms derived from pheochromocytoma ; craniosynostosis[en.wikipedia.org] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com]

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