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75 Possible Causes for Creatine Kinase Normal or Increased, Difficulty Climbing Stairs, Vacuolization

  • Limb-Girdle Muscular Dystrophy

    climbing stairs or getting up from chairs.[sharecare.com] […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] Patients with congenital and mitochondrial myopathies usually present normal creatine kinase levels, and frequent ptosis.[doi.org]

  • Limb-Girdle Muscular Dystrophy Type 1E

    LGMD1 patients may need to use walking aids, can have difficulties climbing stairs and lose the ability to walk.[mdfgauteng.org] Pathologic findings in one of the patients showed rimmed vacuoles.[ncbi.nlm.nih.gov] kinase normal-to-moderate increase Genetic testing gold standard Slit-lamp examination to evaluate for cataracts classically posterior subcapsular cataracts Electrocardiogram[medbullets.com]

  • Oculo-Pharyngo-Distal Myopathy

    climbing stairs Lower limb muscle weakness Limb muscle weakness Pectus carinatum Dysphonia Hypomimic face Lactic acidosis Congenital cataract Hypertrophic cardiomyopathy[mendelian.co] Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] climbing stairs, arising from a low chair or toilet, or getting up from a squatted position.[slideplayer.com]

  • Glycogen Storage Disease Type 2

    climbing stairs Frequent falls Scapular winging Respiratory Frequent infections Respiratory insufficiency Cardio-respiratory failure (death) Respiratory failure/insufficiency[cuh.nhs.uk] At juvenile onset, a more moderate vacuolization without significant differences in overall morphology is notable.[ncbi.nlm.nih.gov] Laboratory results are significant for an elevated creatine kinase level of 1,423 U/L (normal 200 U/L). There was no increase of lactate on forearm nonischemic testing.[medbullets.com]

  • Muscular Dystrophy

    Symptoms may include: Progressive muscle weakness and wasting (atrophy) Waddling way of walking Difficulty climbing stairs Difficulty rising from lying or sitting Repeated[cedars-sinai.edu] Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation . J Neurol Sci, 1981; 51: 141–155.[link.springer.com] Serum creatine kinase concentration is usually normal but is sometimes increased by up to 3-fold.[orpha.net]

  • Distal Myopathy Type 3

    Eventually, affected individuals may have difficulty climbing stairs or walking for an extended period of time.[ghr.nlm.nih.gov] Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] Serum creatine kinase concentration is usually normal but is sometimes increased by up to 3-fold.[orpha.net]

  • Sarcotubular Myopathy

    Patients may complain of difficulty climbing stairs or fixing their hair in the morning.[hickoryneurology.net] The vacuoles are similar to those described in sarcotubular myopathy. TRIM32 sequencing revealed the common c.1459G A mutation at homozygosity.[ncbi.nlm.nih.gov] Asymptomatic individuals may also present with a high creatine kinase (CK) level or malignant hyperthermia.[slideshare.net]

  • Childhood Dermatomyositis

    A child with JM has great difficulty climbing stairs and just getting up from a sitting position. Walking and running become very challenging and exhausting.[curejm.org] Numerous dark-stained fibers and vacuoles were observed in periodic acid-Schiff (PAS) staining.[ijdvl.com] […] correlates with successful treatment); and (d) dynamic range (increases in creatine kinase with PM/DM are often 20–50 times normal).[rheumaknowledgy.com]

  • Inclusion Body Myositis

    Case 5 A 52-year-old HIV-positive man presented with a 2-year history of fatigue and difficulties climbing stairs.[karger.com] The coexistence of ring fibres, rimmed vacuoles and inclusion-body myositis-type inclusions in a child with congenital myopathy has not been previously reported.[ncbi.nlm.nih.gov] Labs including CBC, CMP, ANA, ESR, CRP, and TSH were normal. Serum creatine kinase was 6,500.[n.neurology.org]

  • Granulomatous Myositis

    58275 What treatment is recommended for Granulomatous Myositis Some features of body myositis, muscle wastage causing unsteadiness walking, and extreme difficulty climbing[healthmagic.gq] Vacuoles Acid maltase positive lysosomal vacuoles. Rimmed vacuoles inclusion body myositis. Freezing artifacts (clear). PAS glycogen storage disease.[librepathology.org] Serum creatine kinase level was normal. View larger version (59K) Fig. 27 — 68-year-old man with newly diagnosed Shulman's syndrome.[ajronline.org]

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