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3,453 Possible Causes for Creatine Kinase Normal or Increased, Vacuolization, Weight Loss due to Dysphagia

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] Myopathological findings showed rimmed vacuoles with varying degrees of muscular dystrophic changes.[ncbi.nlm.nih.gov] Histological features included basophilic-rimmed vacuoles, but the typical OPMD intranuclear filaments were absent.[ncbi.nlm.nih.gov]

  • Inclusion Body Myositis

    The coexistence of ring fibres, rimmed vacuoles and inclusion-body myositis-type inclusions in a child with congenital myopathy has not been previously reported.[ncbi.nlm.nih.gov] Besides, it can lead to unintended weight loss. Due to a higher incidence of aspiration pneumonia, life expectancy is assumed to be shorter [ 12 ].[link.springer.com] Labs including CBC, CMP, ANA, ESR, CRP, and TSH were normal. Serum creatine kinase was 6,500.[n.neurology.org]

  • Distal Myopathy Type 3

    Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] Serum creatine kinase concentration is usually normal but is sometimes increased by up to 3-fold.[orpha.net] Table 2 Differential diagnosis of distal myopathies CREATINE KINASE The serum creatine kinase concentration may be helpful if it is increased but it may be normal or only[jnnp.bmj.com]

    Missing: Weight Loss due to Dysphagia
  • Hemangioblastoma

    Microscopically, the neoplasm was seen to be composed of vascular channels associated with foamy stromal cells, containing clear cytoplasmic vacuoles.[ncbi.nlm.nih.gov] loss or aspiration); stage III decompensated abnormal function with weight loss of 10% or less of body weight over 6 months due to dysphagia, or daily cough, gagging, or[neurologyindia.com] Tumor was composed of numerous capillaries and stromal cells with cytoplasmic vacuolization.[ncbi.nlm.nih.gov]

    Missing: Creatine Kinase Normal or Increased
  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] Surgery may also help relieve problems due to dysphagia and should be considered if there is marked weight loss, near-fatal choking, or recurrent pneumonia.[genpharmservices.com] Innervated cultures had large cytoplasmic vacuoles in a number of muscle fibers.[ncbi.nlm.nih.gov]

    Missing: Creatine Kinase Normal or Increased
  • Amyotrophic Lateral Sclerosis

    Cytoplasmic vacuoles were found in the remaining anterior horn motor neurons of the lumbar spinal cord.[ncbi.nlm.nih.gov] Weight loss in ALS is caused by muscle wasting due to motor neuron death, increased resting energy expenditure, and decreased food intake.[en.wikipedia.org] Clinical laboratory tests that may be abnormal in otherwise typical case of ALS include [ 9 ]: • Muscle enzymes (serum creatine kinase [unusual above ten times upper limit[doi.org]

  • Liposarcoma

    […] lesions occurred in the tongue of a 30-year-old man and in the triceps of a 67-year-old woman and were characterized by bland, epithelioid cells with striking intracytoplasmic vacuolization[ncbi.nlm.nih.gov] RESULTS: An 81-year-old man presented with a 5-month history of dysphagia and 30-kg weight loss, due to a giant pedunculated liposarcoma of the hypopharynx, which is resected[ncbi.nlm.nih.gov] Bizarre appearing lipoblasts displaying scalloped nucleus having multiple cytoplasmic vacuolations were also seen [Figure 2], lower inset].[ccij-online.org]

    Missing: Creatine Kinase Normal or Increased
  • Sarcotubular Myopathy

    The vacuoles are similar to those described in sarcotubular myopathy. TRIM32 sequencing revealed the common c.1459G A mutation at homozygosity.[ncbi.nlm.nih.gov] Asymptomatic individuals may also present with a high creatine kinase (CK) level or malignant hyperthermia.[slideshare.net] Myriad small spaces appeared in abnormal fibers in the transverse sections, while in longitudinal sections the vacuolation was segmental in distribution.[mayoclinic.pure.elsevier.com]

    Missing: Weight Loss due to Dysphagia
  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] Patients with congenital and mitochondrial myopathies usually present normal creatine kinase levels, and frequent ptosis.[doi.org] Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[ncbi.nlm.nih.gov]

    Missing: Weight Loss due to Dysphagia
  • Yolk Sac Tumor

    They are lined by a single layer of columnar cells with subnuclear and supranuclear cytoplasmic vacuolation resembling early secretory endometrium.[ijpmonline.org] The patient presented with a cough with whitish sputum, history of hemoptysis, loss of weights, and dysphagia.[exp-oncology.com.ua] Cells with large cytoplasmic vacuolation were infrequent and few hobnail shaped tumor cells. 5,7 On the other hand, YST showed more dyscohesive cells with marked cellular[biocoreopen.org]

    Missing: Creatine Kinase Normal or Increased

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