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76 Possible Causes for Creatine Phosphokinase Increased, Foot Drop

  • Tetanus

    Increasing serum creatinine was temporally associated with rising creatine phosphokinase (CPK) and striking elevations of plasma myoglobin.[] We found this case to be associated with dysphagia and facial spasm, and we learned that the child had dropped a brick on his foot 2 weeks previously.[] Eventually she developed characteristic findings of increased tone in her masseter muscles (trismus) and rigid upper and lower extremities, consistent with generalized tetanus[]

  • Amyotrophic Lateral Sclerosis

    This usually begins on one side of the body and can cause loss of hand dexterity, shoulder function, a foot-drop or walking difficulty.[] The patient may develop foot drop resulting in a fall or sprain. Fasciculations may present early on in the disease, particularly in the tongue.[] Clinical examination revealed right foot drop, distal amyotrophy of the right lower limb, and fasciculations in the 4 limbs.[]

  • Autosomal Recessive Inclusion Body Myopathy Type 2

    High serum creatine kinase Increased CPK Increased creatine kinase Increased creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine[] Symptoms of the disease usually appear between 20 and 40 years of age and include foot drop and difficulty walking.[] Typically, distal weakness in the legs with foot drop is the first sign, followed by (usually) slow progression to the proximal muscles (thigh) and the upper limbs (hand muscles[]

  • Osteoporosis

    Most of the increases in creatine phosphokinase were transient, and in more than 88 percent of the patients who had high concentrations, the values returned to the normal[] […] levels have dropped too low during the night, when you are not consuming food.[] No increase in muscular symptoms or other biologic abnormalities were observed.[]

  • Muscular Dystrophy

    drop (foot dorsiflexion weakness); Weak lower abdominal muscles, protuberant abdomen; Atrophy of chest (pectoral) muscles; Curved spine (lordosis).[] The diagnosis of muscular dystrophy is based on the results of muscle biopsy, increased creatine phosphokinase (CpK3), electromyography, and genetic testing.[] The selective pattern of muscle weakness in the lower limbs and back may include: foot drop due to weakness of muscles in the front of the leg weakened ability to straighten[]

  • Myopathy

    The laboratory evaluation was remarkable for the marked increase in the serum lactate dehydrogenase and creatine phosphokinase levels.[] The proband showed foot drop, scoliosis, and winged scapula, while his mother only showed mild foot drop and winged scapula.[] Initially, increased tripping and a steppage gait are often noted because of foot drop.[]

  • Inclusion Body Myositis

    A foot-drop can increase the likelihood of tripping.[] Foot drop is seen, but is considered a late manifestation of the disease process.[] Associated clinical findings include asymmetric weakness, foot drop and dysphagia. [ 10 ] Weakness is often asymmetrical in contrast to polymyositis.[]

  • Tropical Myositis

    Muscle enzymes (aldolase, creatine phosphokinase, aminotransferase, and lactic dehygrogenase) are usually normal or slightly raised.[] O/E Pt well built Not pale/icteric/cyanosed/clubbing/sig gen lymphadenopathy Vitals Normal CVS,RS,Abdomen—Normal Rt LL- swollen,erythematous,warm,tense,tender Rt foot drop[] Interestingly, creatine phosphokinase and aldolase levels is found to be normal in pyomyositis [ 1 , 11 ].[]

  • Haff Syndrome

    In the occurrence of suspected cases, it is recommended to test for creatine phosphokinase (CPK) or OGT to observe the increase of muscle enzymes.[] Drop 386 Case 61 An Elderly Woman with Foot Drop and Hand Weakness 393 Case 62 A Woman with Rheumatoid Arthritis Who Developed Numbness and Pain in the Feet 399 Case 63 A[] […] and Slow Nerve Conduction Velocities 372 Case 58B A Boy with Leg Weakness 375 Case 59 A Man with Hand Weakness and Numbness After Skiing 383 Case 60 A Man with Recurrent Foot[]

  • Limb-Girdle Muscular Dystrophy

    We present a 19-year-old girl with epilepsy and elevated creatine phosphokinase (CPK) concentration.[] One case is reported as presenting with foot drop - aged 41. [ 24 ] LGMD 2B (dysferlin) also known as Miyoshi myopathy Late teens, early 20s May have distal myopathy (Miyoshi[] Observation of the gait can reveal signs of distal weakness such as foot drop or an inability to walk on toes.[]

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