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10 Possible Causes for Creatine Phosphokinase Increased, Lactate Dehydrogenase Increased, Percussion Myotonia

  • Myotonia Congenita

    The diagnosis were based upon family history, clinical findings of percussion myotonia, had grip myotania, prominent muscular hypertrophy and confirmed by electromyographic[ncbi.nlm.nih.gov] Distribution/anatomy Time course Onset/age Myotonia is usually mild, approximately 50% may have percussion myotonia.[rrnursingschool.biz] On examination he showed percussion myotonia. There was no grip myotonia or eyelid myotonia. Nerve conduction studies were normal.[jnnp.bmj.com]

  • Myopathy

    The laboratory evaluation was remarkable for the marked increase in the serum lactate dehydrogenase and creatine phosphokinase levels.[ncbi.nlm.nih.gov] Myotonia can be elicited by percussion, occurs by impaired relaxation of muscle due to repetitive depolarization of the muscle.[doi.org] Cirioni O, Weimer LE, Fragola V, et al.(2013) Sustained Increase of Serum Creatine Phosphokinase Levels and Progressive Muscle Abnormalities Associated with Raltegravir use[hiv.imedpub.com]

  • Secondary Myopathy

    Phosphofructokinase Deficiency caused by mutations in the PFKM gene Phosphoglycerate kinase deficiency X-linked Muscle Lactate Dehydrogenase Deficiency (LDH) deficiency is[sites.google.com] Cirioni O, Weimer LE, Fragola V, et al.(2013) Sustained Increase of Serum Creatine Phosphokinase Levels and Progressive Muscle Abnormalities Associated with Raltegravir use[hiv.imedpub.com] Muscle hypertrophy may be seen Grip and percussion myotonia can be seen Tx : Mexiletene.[sites.google.com]

  • Myoadenylate Deaminase Deficiency

    Ischemic exercise failed to increase the blood ammonia, while lactate increased normally.[ncbi.nlm.nih.gov] "Action" or grip myotonia may be seen. However, percussion myotonia is rare. There may be an associated neuropathy.[neuroweb.us] phosphokinase, hypoketotic hypoglycemia, and increased lipid in muscle.[rheumaknowledgy.com]

  • Myoglobinuria

    […] mechanisms, thereby increasing free ionized calcium (cytoplasm).[en.wikipedia.org] "Action" or grip myotonia may be seen. However, percussion myotonia is rare. There may be an associated neuropathy.[neuroweb.us] creatine phosphokinase (CK) in serum and appearance of small amounts of myoglobin in the urine, but without clinical symptoms.[ncbi.nlm.nih.gov]

  • Proximal Myopathy with Extrapyramidal Signs

    Frequency not reported : ALT increased, AST increased Postmarketing reports : Cholestatic hepatitis, cholestasis, jaundice, alkaline phosphatase increased, blood lactate[drugs.com] "Action" or grip myotonia may be seen. However, percussion myotonia is rare. There may be an associated neuropathy.[neuroweb.us] High serum creatine kinase Increased CPK Increased creatine kinase Increased creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine[rarediseases.info.nih.gov]

  • Distal Myopathy Type 3

    Phosphofructokinase Deficiency caused by mutations in the PFKM gene Phosphoglycerate kinase deficiency X-linked Muscle Lactate Dehydrogenase Deficiency (LDH) deficiency is[sites.google.com] "Action" or grip myotonia may be seen. However, percussion myotonia is rare. There may be an associated neuropathy.[neuroweb.us] High serum creatine kinase Increased CPK Increased creatine kinase Increased creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine[rarediseases.info.nih.gov]

  • Rigid Spine Syndrome

    lactate dehydrogenase activity Nonketotic hypoglycemia Multiple myeloma Hyperphosphatemia Patent ductus arteriosus Encephalopathy Hernia Depressivity Impaired reabsorption[mendelian.co] […] nigricans Hypertriglyceridemia Atrial fibrillation Macrocephaly Accelerated skeletal maturation Recurrent bacterial infections Insulin resistance Epidermal acanthosis Hirsutism Percussion[mendelian.co] […] variability in muscle fiber diameter Constipation Hypoventilation Hypertension Mildly elevated creatine phosphokinase Muscular dystrophy Infantile onset Heterogeneous Facial[mendelian.co]

  • Autosomal Dominant Myoglobinuria

    Moses GC, Henderson AR (1987) Increased serum lactate dehydrogenase isoenzyme 1 and “flipped” LD-1/LD-2 ratio in myopathy associated with partial carnitine palmitoyltransferase[link.springer.com] "Action" or grip myotonia may be seen. However, percussion myotonia is rare. There may be an associated neuropathy.[neuroweb.us] […] with common exertional activities (e.g. 20x normal at 1 day after marathon) See Creatine Phosphokinase Myoglobin level increased Increased in urine or serum, but has lower[fpnotebook.com]

  • X-Linked Scapuloperoneal Myopathy

    In lactate dehydrogenase deficiency, venous levels of lactate do not increase, but pyruvate rises to normal.[basicmedicalkey.com] Myotonia (prolonged muscle contraction) occurs spontaneously or is elicited by voluntary activity or by mild stimulation, such as tapping on a muscle (percussion myotonia)[neuropathology-web.org] Increased CPK Increased creatine kinase Increased creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine phosphokinase Last updated[rarediseases.info.nih.gov]

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