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73 Possible Causes for Creatine Phosphokinase Increased, Mild Facial Muscle Weakness

  • Muscular Dystrophy

    Mild involvement of the facial musculature (particularly of the orbicularis oculi and oris muscles) is often present.[orpha.net] The diagnosis of muscular dystrophy is based on the results of muscle biopsy, increased creatine phosphokinase (CpK3), electromyography, and genetic testing.[en.wikipedia.org] Muscle weakness of the face is common, and may include: Eyelid drooping Inability to whistle Decreased facial expression Depressed or angry facial expression Difficulty pronouncing[web.archive.org]

  • Inclusion Body Myositis

    Facial muscles are unaffected in PM and DM, but mild facial muscle weakness is common in patients with IBM.[accessmedicine.mhmedical.com] phosphokinase (CPK) and inflammatory cell infiltration.[emedicine.medscape.com] There is early weakness and atrophy of forearms and quadriceps and a third of patients also have mild facial weakness.[ncbi.nlm.nih.gov]

  • Polymyositis

    There was increased proximal muscle strength and reduction in the creatine phosphokinase level.[rheumatology.oxfordjournals.org] Facial muscles are unaffected in PM and DM, but mild facial muscle weakness is common in patients with IBM.[accessmedicine.mhmedical.com] In five patients with refractory juvenile dermatomyositis, muscle strength increased and creatine phosphokinase levels decreased with combination therapy.[rheumatology.oxfordjournals.org]

  • Progressive Muscular Atrophy

    Experience mild weakness in their facial muscles. Weakness begins in the upper arm and lower leg muscles.[disabled-world.com]

  • Limb-Girdle Muscular Dystrophy Type 2A

    High serum creatine kinase Increased CPK Increased creatine kinase Increased creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine[rarediseases.info.nih.gov] Affected individuals develop weakness of the lower limbs that may be mild or severe. Weakness of facial muscles may also occur.[rarediseases.org] […] kinase Elevated blood creatine phosphokinase Elevated circulating creatine phosphokinase Elevated creatine kinase Elevated serum CPK Elevated serum creatine phosphokinase[rarediseases.info.nih.gov]

  • Secondary Myopathy

    Cirioni O, Weimer LE, Fragola V, et al.(2013) Sustained Increase of Serum Creatine Phosphokinase Levels and Progressive Muscle Abnormalities Associated with Raltegravir use[hiv.imedpub.com] Mild facial weakness may be seen even when limb weakness is relatively mild (rare in DM and PM), and dysphagia can be an early or late feature.[jnnp.bmj.com] Mild facial weakness, neck weakness usually occurs.[sites.google.com]

  • Limb-Girdle Muscular Dystrophy

    We present a 19-year-old girl with epilepsy and elevated creatine phosphokinase (CPK) concentration.[ncbi.nlm.nih.gov] Affected individuals develop weakness of the lower limbs that may be mild or severe. Weakness of facial muscles may also occur.[rarediseases.org] Some patients, however present with mild facial paresis.[symptoma.com]

  • Myopathy

    The laboratory evaluation was remarkable for the marked increase in the serum lactate dehydrogenase and creatine phosphokinase levels.[ncbi.nlm.nih.gov] Nemaline myopathy: moderate weakness of voluntary muscles in the arms, legs, and trunk; mild weakness of facial muscles; delays in reaching developmental motor milestones;[healthofchildren.com] Cirioni O, Weimer LE, Fragola V, et al.(2013) Sustained Increase of Serum Creatine Phosphokinase Levels and Progressive Muscle Abnormalities Associated with Raltegravir use[hiv.imedpub.com]

  • Amyotrophic Lateral Sclerosis

    Family history; fasciculations of facial muscles; gynaecomastia; proximal symmetrical weakness in addition to foot drop; mild sensory neuropathy on NCS; positive DNA test[doi.org] […] improvement with intravenous immunoglobulin (IVIG) in 70% Kennedy's disease (X-linked bulbar and spinal muscular atrophy) Males symptomatic; slowly progressive bulbar and limb weakness[doi.org]

  • Congenital Muscular Dystrophy

    The diagnosis of muscular dystrophy is based on the results of muscle biopsy, increased creatine phosphokinase (CpK3), electromyography, and genetic testing.[en.wikipedia.org] Atrophy and weakness of facial muscles, ptosis, and frontal baldness produce a characteristic facial appearance.[neuropathology-web.org] The laboratory investigations displayed an increased level of serum creatine phosphokinase (CK) present since the neonatal period and persisting elevated in all children with[doi.org]

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