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30 Possible Causes for Creatine Phosphokinase Increased, primarily in the legs, severe muscle wasting

Did you mean: Creatine Phosphokinase Increased, primarily in the legs, severe, muscle wasting

  • Muscular Dystrophy

    Remorseless cycles of muscle fibre breakdown and incomplete repair lead to progressive and severe muscle wasting, weakness and premature death.[] The diagnosis of muscular dystrophy is based on the results of muscle biopsy, increased creatine phosphokinase (CpK3), electromyography, and genetic testing.[] […] and hips) in the forearms, hands, lower legs, and feet.[]

  • Amyotrophic Lateral Sclerosis

    Excluding lower motor neuron FA and FL cases, progressive muscular atrophy comprised 4% of the sample and had a prognosis similar to typical limb onset ALS.[] […] by often asymmetric and primarily distal LMN involvement in the lower limbs.[] atrophy and related syndromes G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman] G12.1 Other inherited spinal muscular atrophy G12.2 Motor neuron disease G12.21[]

  • Limb-Girdle Muscular Dystrophy

    atrophy.[] We present a 19-year-old girl with epilepsy and elevated creatine phosphokinase (CPK) concentration.[] Miyoshi myopathy (median age of onset 19 years) is characterized by muscle weakness and atrophy, most marked in the distal parts of the legs, especially the gastrocnemius[]

  • Dermatomyositis

    atrophy).[] Elevated creatine phosphokinase increases the suspicion of an inflammatory muscle disease, and muscle biopsy is the definitive diagnostic tool for inflammatory myopathies.[] They are primarily used after injury or surgery to immobilize the leg. They are larger in size than other braces, due to their function.[]

  • Duchenne Muscular Dystrophy

    They are primarily used after injury or surgery to immobilize the leg. They are larger in size than other braces, due to their function.[] Abstract Duchenne muscular dystrophy (DMD) is a rare, severe, progressive muscle-wasting disease leading to disability and premature death.[] […] and hips) in the forearms, hands, lower legs, and feet.[]

  • Inclusion Body Myositis

    Sporadic inclusion body myositis (sIBM) is a slowly progressive, red-rimmed vacuolar myopathy leading to muscular atrophy and progressive weakness; it predominantly affects[] phosphokinase (CPK) and inflammatory cell infiltration.[] […] pelvic region and legs, usually seen in older people.[]

  • Myopathy

    Electromyography Excludes primarily neurogenic processes (for example, spinal muscular atrophy).[] The laboratory evaluation was remarkable for the marked increase in the serum lactate dehydrogenase and creatine phosphokinase levels.[] When comparing exercised to nonexercised legs, numerous genes (80) were expressed differentially between legs and were primarily involved in cell cycling and growth, signal[]

  • Myotonia Congenita

    Clinical description Myotonia congenita and paramyotonia congenita are skeletal muscle disorders characterized by muscle stiffness that is not accompanied by muscle wasting[] Muscle tissue is composed primarily of contractile cells. Contractile cells have the ability to produce movement.[] MAD deficiency have been described in muscle biopsy of patients with polyneuropathy, infantile spinal muscular atrophy, congenita myopathy with type-2 fiber atrophy, facioscapulohumeral[]

  • Central Nervous System Disorder

    atrophy Degenerative nerve diseases can be serious or life-threatening.[] Weakness primarily affects the neck, arms, and upper portion of the legs—making it difficult to stand up from a sitting position.[] […] rigidity, tremors, or seizures Muscle wasting and slurred speech Older children may also report persistent or severe headaches, loss of feeling or tingling, or visual changes[]

  • Steroid Myopathy

    Palpation revealed symmetric muscular atrophy at the pelvic and shoulder girdles. No signs of effusion or ecchymosis were present.[] At the same time, there was no or only a slight increase in the creatine phosphokinase level, while the SGOT and aldolase levels remained normal.[] […] proximal muscle of lower extremities, and the distal muscles are rarely affected. [9] In the current study, however, palpation pain was found on both tibial anterior legs[]

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