Creatinine Increased: Causes & Reasons

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Possible Causes for Creatinine Increased

Acute Kidney Injury

The second aim was to remark that this syndrome is characterised by a spectrum of progressive damage, from mild creatinine increase to renal injury to a more severe form, [ncbi.nlm.nih.gov]

[…] a creatinine increase of more than 0.3 mg/dl from an elevated baseline represents AKI and has the same risks as a creatinine increase from a normal baseline). 6. [ncbi.nlm.nih.gov]

[…] ml/kg per hour for more than 12 hours 3 c Increase in serum creatinine to more than 300% (> 3-fold) from baseline (or serum creatinine of more than or equal to 4.0 mg/dl [ [doi.org]

Postrenal Azotemia

*A threefold increase in serum creatinine or a serum creatinine level ≥ 4.0mg/dL with an acute rise > 0.5 mg/dL indicates renal failure. [jaoa.org]

The increased nephron tubular pressure is the reason for increased reabsorption of BUN, raising it abnormally relative to creatinine. [consultation.ayurvediccure.com]

Stage I was defined as an increase in serum creatinine of 26.5 µmol/l (0.3 mg/dl) or of 150–200%, stage II as an increase in serum creatinine of 200–300%, and stage III as [nature.com]

Hepatorenal Syndrome

Serum creatinine was increased to 3.5 mg/dl. [ncbi.nlm.nih.gov]

For therapeutic purposes, HRS is usually diagnosed only when serum creatinine increases to >133 μmol/L (1.5mg/dl). [easl.eu]

Treatment with terlipressin and albumin was associated with a remarkable decrease in serum creatinine level, increase in arterial pressure, and suppression of the renin-aldosterone [ncbi.nlm.nih.gov]

Non-Allergic Interstitial Nephritis

*A threefold increase in serum creatinine or a serum creatinine level ≥ 4.0mg/dL with an acute rise > 0.5 mg/dL indicates renal failure. [jaoa.org]

creatinine and BUN. [sharinginhealth.ca]

A nephrologist should always be consulted in severe cases (robust increases of creatinine value, robust proteinurie, oliguria or anuria, increases in body weight) for further [thieme-connect.com]

Acute Tubular Necrosis

Urea is increased more than creatinine (because urea is being reabsorbed) There is a disproportionate increase of BUN and creatinine. [medicowesome.com]

Within days after the onset of therapy, both developed renal insufficiency manifested by elevated serum creatinine levels, increased proteinuria, and active urinary sediments [ncbi.nlm.nih.gov]

The increase in epidermal growth factor binding in the kidney after acute tubular necrosis and the attenuation of the increase in serum creatinine concentration by administration [clinsci.org]

Tumor Lysis Syndrome

Creatinine increased to 1.8 mg/dL from 1.5 mg/dL. There is no evidence of infection. [jsms.sch.ac.kr]

increase of ≥ 26.5 μmol/L (≥ 0.3 mg/dL)*** Oliguria (< 0.5 mL/kg/h for 6 hours) Symptomatic hypocalcemia**** Cardiac dysrhythmia Seizure Sudden death *** or creatinine ≥ [bloodref.com]

CONCLUSION: Our data indicated that single-dose rasburicase effectively prevented progression of TLS, and, regardless of any risk factors, including increased creatinine, [ncbi.nlm.nih.gov]

Radiocontrast Nephropathy

The outcome of RCN was defined as an absolute creatinine increase of greater than or equal to 0.5 mg/dL, or a 25% increase above baseline. [ncbi.nlm.nih.gov]

2 patients (0.3%) who had greater than 0.5 mg/dL increase serum creatinine and 25% or greater increase in serum creatinine in 48 hours. [ispub.com]

There was no significant difference between the number of patients who had increased creatinine versus decreased creatinine. [emcrit.org]

Dopamine Beta-Hydroxylase Deficiency

Elevated creatinine High blood creatinine level Increased creatinine Increased serum creatinine [ more ] 0003259 Exercise-induced muscle fatigue 0009020 Fatigue Tired Tiredness [rarediseases.info.nih.gov]

[ more ] 0012378 Hypoglycemia Low blood sugar 0001943 Increased blood urea nitrogen 0003138 Reduced tendon reflexes 0001315 Retrograde ejaculation 0012877 Sleep disturbance [rarediseases.info.nih.gov]

[…] upon standing up 0001278 Rhinitis Nasal inflammation 0012384 30%-79% of people have these symptoms Anemia Low number of red blood cells or hemoglobin 0001903 Elevated serum creatinine [rarediseases.info.nih.gov]

Scleroderma with Renal Involvement

Creatinine test As kidney function declines, your creatinine increases. This protein is also related to muscle mass. [healthline.com]

His serum creatinine gradually increased from 2.2mg/dl at presentation to 3.0 mg/dl at the time of discharge. [jpma.org.pk]

CONCLUSION: Patients with diffuse scleroderma without renal crisis rarely have significant increases in serum creatinine or proteinuria that cannot be explained by other etiologies [jrheum.org]

Cholesterol Embolism

However, the patient's toes soon darkened bilaterally, and BUN and creatinine levels increased from the normal value. [ncbi.nlm.nih.gov]

Serum creatinine increased to 7.4 mg/dL in the next 10 days. [sjkdt.org]

Creatinine increased to 8 mg/dl, BUN 250 mg/dl and decreased urine output with water overload led us consider initiating hemodialysis. [oatext.com]

Malignant Nephrosclerosis

Damage to the kidneys may be demonstrated by: BUN increase Creatinine increase Arterial blood gas analysis showing metabolic acidosis Urinalysis showing high proteinlevels [medical-dictionary-search-engines.com]

In two patients (group I), the integrated average blood pressure (IA-BP) was 134/95 mmHg (median) and the calculated creatinine clearance (Ccr) increased from 19 to 56 ml/ [ncbi.nlm.nih.gov]

This may lead to a slowing of the renal cortical and glomerular blood flow, thus inducing an increase of the serum creatinine concentration. [ncbi.nlm.nih.gov]

IgA Nephropathy

The primary end point was an increase of 50 percent or more in the serum creatinine concentration at the end of the study. [doi.org]

Serum creatinine concentrations, elevated in 68 percent of the patients at base line, and creatinine clearance were measured for two years. [ncbi.nlm.nih.gov]

An increase > 25 % of serum creatinine before CyP 1 was observed in 8 patients after 0.7 years (range, 0.3 to 3.0 years), and three patients of these developed end-stage renal [oparu.uni-ulm.de]

Chronic Kidney Insufficiency

AKI is defined as any of the following: Increase in serum creatinine concentration by 0.3 mg/dL in 48 hours, OR Increase in serum creatinine concentration by more than 50% [wikidoc.org]

Creatinine test As kidney function declines, your creatinine increases. This protein is also related to muscle mass. [healthline.com]

Once any sign (such as an increase in creatinine) of disease is detected, it is imperative that immediate steps be taken to halt its progress, as kidney function can decline [lifeextension.com]

Lupus Nephritis

Adverse events consisted of one patient with severe infection, two herpes zoster and one with transient increased serum creatinine level. [ncbi.nlm.nih.gov]

She was admitted with malar "butterfly" rash, anasarca and hypertension, associated with an increase in serum creatinine (1.7 mg/dl). [ncbi.nlm.nih.gov]

[…] serum creatinine levels. [auriniapharma.com]

Allergic Interstitial Nephritis

When challenged with a related agent, sorafenib, the patient experienced worsening of serum creatinine and increasing eosinophilia, similar to that noted with sunitinib, suggesting [ncbi.nlm.nih.gov]

The most important diagnostic modalities are lab tests (increased blood urea nitrogen and creatinine ) and urinalysis, although a kidney biopsy may be indicated in select [amboss.com]

Nodular Glomerulosclerosis

However, over a 9-month period, serum creatinine increased gradually from 2.4 to 6.3 mg/dL. [ekjm.org]

Dose should be decreased if symptoms of orthostatic hypotension develop or serum creatinine increases by more than 30%. [merckmanuals.com]

A renal biopsy to assess a progressive increase in serum creatinine levels 11 years posttransplantation showed features of nodular glomerulosclerosis. [ncbi.nlm.nih.gov]

Diabetic Nephropathy

Dose should be decreased if symptoms of orthostatic hypotension develop or serum creatinine increases by more than 30%. [merckmanuals.com]

Medullary Cystic Kidney Disease Type 1

Elevated creatinine High blood creatinine level Increased creatinine Increased serum creatinine [ more ] 0003259 Glomerular sclerosis 0000096 Gout 0001997 Hypertension 0000822 [rarediseases.info.nih.gov]

Laboratory testing may show an increase in serum creatinine. At a later stage, kidney disease may lead to high blood pressure, anemia, and gout. [rarediseases.info.nih.gov]

Cerebral cortical atrophy Decrease in size of the outer layer of the brain due to loss of brain cells 0002120 Decreased glomerular filtration rate 0012213 Elevated serum creatinine [rarediseases.info.nih.gov]

Rapidly Progressive Glomerulonephritis

Her serum level of creatinine was increased (4.4 mg/dL), and her hemoglobin concentration was reduced (8.0 g/dL). [ncbi.nlm.nih.gov]

In addition, his serum creatinine level greatly increased to 4.6 mg/dl. His prevalent renal illness was thought to be rapidly progressive glomerulonephritis (RPGN). [ncbi.nlm.nih.gov]

After starting this therapy, the creatinine level decreased and creatinine clearance improved to almost normal values. However, proteinuria increased to about 10 g/d. [onlinelibrary.wiley.com]

Acquired Fanconi Syndrome

Italian aumento della creatinina, tubulopatia renale prossimale (inclusa la sindrome di Fanconi) English increased creatinine, proximal renal tubulopathy (including Fanconi [mymemory.translated.net]

With increasing use of tenofovir as first-line ART clinicians must be aware of this complication. [indianjnephrol.org]

Last Update: 2017-04-26 Usage Frequency: 4 Italian aumento della creatinina, proteinuria, tubulopatia renale prossimale inclusa la sindrome di Fanconi English increased creatinine [mymemory.translated.net]

Chronic Lead Nephropathy

A longitudinal analysis of the Normative Aging Study found that a 10-fold increase in blood lead levels predicted a 0.08 mg/dL increase in serum creatinine levels. [emedicine.medscape.com]

The primary end point was an increase in the serum creatinine level to 1.5 times the base-line value during the observation period. [nejm.org]

[…] dipstick protein testing but detected using radioimmunoassay) Increased urinary cadmium levels ( > 7 μ g/g creatinine) Treatment is elimination of cadmium exposure; note [merckmanuals.com]

Renal Infarction

Although hemodialysis was performed 9 times and the urine output was satisfactory, the creatinine clearance levels increased only to about 50 mL/min/1.73 m2 (0.84 mL/s/m2) [ncbi.nlm.nih.gov]

OUTCOMES: We used recurrence, acute kidney injury (AKI; defined as creatinine level increase ≥ 0.3mg/dL within 48 hours or an increase to 150% of baseline level within 7 days [ncbi.nlm.nih.gov]

Studies show that 11– 35% of patients experience a transient increase in serum creatinine levels (defined as a > 30% increase in serum creatinine level), and 0–4% of patients [ctisus.com]

Kidney Disease

As kidney function declines, the levels of creatinine increase. An equation is used to determine GFR. [nephcure.org]

Increased muscle mass or increased protein intake could also have increased the mean serum creatinine concentration. [doi.org]

The main way of estimating GFR is a blood test to determine the level of Creatinine in the blood, or serum creatinine. [nephcure.org]

Chronic Glomerulonephritis

Some authors have found that persistent hypertension, serum creatinine increase at diagnosis, and macroscopic hematuria episodes are also related to worse prognosis. [kidneypathology.com]

In all 20 patients with chronic renal failure hyperkynureninemia develops due to decreased renal function (increased serum kynurenine, neopterin and creatinine concentrations [ncbi.nlm.nih.gov]

In PGN, according to increase of histological grade and decrease of creatinine clearance, the number of TUNEL-positive cells in glomeruli is decreased in spite of an increase [ncbi.nlm.nih.gov]

Focal Embolic Glomerulonephritis

[…] excretion increases in moderate renal failure, and creatinine clearance rates tend to overestimate GFR. [glowm.com]

[…] in Creatinine Sarcoidosis Renal Disease Salt Wasting, Renal and Cerebral Schistosomiasis and Glomerular Disease Schimke immuno-osseous dysplasia Scleroderma Renal Crisis [kidney.nyc]

[…] and/or BUN Ultrasound : possibly enlarged kidneys, increased echogenicity Renal biopsy (see “Pathology” below) References: [1] [15] [16] Pathology Renal biopsy Indication [amboss.com]

Acute Glomerulonephritis

Serum creatinine then started to increase again. The slope of creatinine clearance over time became steeper after the episode of PSAGN. [ncbi.nlm.nih.gov]

– Urea & creatinine – may be eleveated – Renal biopsy – features of glomerulnepritis 11. [slideshare.net]

Diagnostic Tests Urinalysis Hematuria (microscopic or gross), proteinuria, sediment, RBC casts Blood chemistry Increased blood urea nitrogen, serum creatinine, and serum lipid [medi-info.com]

Acute Pyelonephritis

[…] diagnosis, two of five patients presented with fever, one had increased creatinine levels and one had positive urine cultures. [ncbi.nlm.nih.gov]

Blood investigations show increased serum creatinine levels. A complete blood picture shows the characteristic increase in the number of eosinophils. [lecturio.com]

The acute pyelonephritis with septic shock group (group 1) showed increased bacteremia compared with the other group (53.1% vs. 24.4%, p = 0.002). [kjccm.org]

Hemolytic Uremic Syndrome

Elevated creatinine High blood creatinine level Increased creatinine Increased serum creatinine [ more ] 0003259 Fever 0001945 Hemiparesis Weakness of one side of body 0001269 [rarediseases.info.nih.gov]

Lab results come back with low platelet count, anemia, and increased creatinine. A peripheral blood shows schistocytes. He is started on IV hydration. [step2.medbullets.com]

Hemolytic-uremic syndrome 0005575 Hyperlipidemia Elevated lipids in blood 0003077 Hypertension 0000822 Increased blood urea nitrogen 0003138 Microangiopathic hemolytic anemia [rarediseases.info.nih.gov]

Renal Sarcoidosis

The mean serum creatinine level in 24 patients was 4.7 ± 2.8 mg/dl, and all patients exhibited a rapid increase in serum creatinine levels. [omicsonline.org]

 Serum creatinine levels- increase ( often first attention to the renal failure). 12.  Proteinuria- modest (nearly always 13. [slideshare.net]

After initiation of infliximab, her steroids were weaned, her creatinine stabilized. [acrabstracts.org]

Thrombotic Thrombocytopenic Purpura

Some of typical features of USS had been, never noted during all the evolution: jaundice with hyperbilirubinemia, increased creatinine, and the presence of schizocytes on [latunisiemedicale.com]

Your doctor will also check your blood for: antibodies, which are proteins that interfere with the enzyme ADAMTS13 creatinine levels, which increase if there’s kidney involvement [healthline.com]

[…] urinary urobilinogen negative Coomb’s test (no antibodies bound to patient RBCs) Urinalysis near normal exclude active sediment Biochemistry increased urea and creatinine [lifeinthefastlane.com]