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126 Possible Causes for Cryoglobulinemia, Easy Bruising, Epistaxis

  • Multiple Myeloma

    bruising or bleeding – due to low platelet numbers Bleeding from the nose or gums Repeated infections or infections that are hard to get rid of Thirst, nausea, vomiting or[betterhealth.vic.gov.au] Patients with a high tumor volume may present with epistaxis.[symptoma.com] Type I multiple myeloma-associated cryoglobulinemia was diagnosed.[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    The covered platelet cells may not work right, resulting in bleeding and easy bruising. Every year, there are five new cases of macroglobulinemia per 1,000,000 people.[uihc.org] A 71-year-old woman presented with malaise, skin bruising, epistaxis, and gingival bleeding of recent and prompt onset. There was no adenopathy.[ncbi.nlm.nih.gov] Type II (mixed) cryoglobulinemia is a systemic vasculitis that may affect many organs, including the skin, leading to ulcerations secondary to immune complex deposition.[ncbi.nlm.nih.gov]

  • Hyperviscosity Syndrome

    […] erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal 35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis[ncbi.nlm.nih.gov] Hyperviscosity syndrome is much more common in monoclonal than in mixed or polyclonal cryoglobulinemia.[ncbi.nlm.nih.gov] Patients may present with any of the following: Spontaneous gum bleeding Epistaxis Rectal bleeding Menorrhagia Persistent bleeding after minor procedures Visual changes range[emedicine.medscape.com]

  • Thrombocytopenia

    It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae,[enerca.org] […] stippling Thalassemia, chronic alcohol use, lead or metal poisoning Ribosomal precipitate (appears as blue granules) throughout the cytoplasm of the red blood cell Cryoglobulin Cryoglobulinemia[aafp.org] It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues A condition in which there is an abnormally small number[icd9data.com]

  • Vasculitis

    Upper respiratory tract lesions include recurrent rhinitis, sinusitis, epistaxis and serous otitis media.[symptoma.com] It represents 70–80% of cryoglobulinemia renal diseases and it is strongly associated with the type II IgM κ mixed cryoglobulinemia.[journals.lww.com] Presenting features may include purpuric rash, recurrent sinusitis, epistaxis, shortness of breath, and/or hemoptysis from alveolar hemorrhage.[emedicine.medscape.com]

  • Cryoimmunoglobulinemic Syndrome

    bruising, mucosal bleeding Less freqeunt epistaxia, gingival bleeding, hematuria Uncertain GI bleeding ?[powershow.com] ., headache, confusion, blurry or loss of vision, hearing loss, and epistaxis ; b) deposit in small arteries and capillaries thereby plugging these blood vessels and causing[en.wikipedia.org] Figure 2 Cutaneous manifestations of mixed cryoglobulinemia (MC).[ojrd.biomedcentral.com]

  • Acquired Hemophilia A

    On admission, she had easy bruising and prolonged activated partial thromboplastin time, but during hospitalization she had severe hemorrhage into the right gluteal and femoral[ncbi.nlm.nih.gov] Persistent wound bleeding and epistaxis suddenly began 6 hours after surgery.[ncbi.nlm.nih.gov] Autoimmune diseases are the most frequently associated disorders and include rheumatoid arthritis, systemic lupus erythematosus, cryoglobulinemia, pemphigus vulgaris, and[ncbi.nlm.nih.gov]

  • Autoimmune Thrombocytopenia

    A decrease in platelets can result in easy bruising, bleeding gums, and internal bleeding.[hopkinsmedicine.org] In March 2003 the patient received high doses IVIg but during that treatment, aggravation of the haemorrhagic diathesis with epistaxis, menorrhea and secondary anaemia (Hb[springerlink.com] […] stippling Thalassemia, chronic alcohol use, lead or metal poisoning Ribosomal precipitate (appears as blue granules) throughout the cytoplasm of the red blood cell Cryoglobulin Cryoglobulinemia[aafp.org]

  • Myeloproliferative Disease

    Most common in chronic myelogenous leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to[emedicine.com] Abnormalities in platelet function lead to bleeding complications that include epistaxis, bruising, and gastrointestinal and gingival bleeding in 5% to 10% of patients. 15[clevelandclinicmeded.com] […] reactive thrombocytosis: acute hemorrhage, recovery of thrombocytopenia, infections, inflammatory diseases, tissue damage, iron deficiency, hemolytic anemia, post splenectomy, cryoglobulinemia[scielo.br]

  • Chronic Lymphocytic Leukemia

    Eastern European Jews Exposure to Agent Orange Symptoms Symptoms include: Painless swelling in the neck, underarms, stomach or groin Tiredness Paleness (a sign of anemia) Easy[cancer.uvahealth.com] Epistaxis, gastrointestinal bleeding, and to the formation of hematomas are also common. CLL patients also tend to autoimmune reactions.[symptoma.com] Callard, Magali Colombat, Jean Cabane, Jean-Jacques Boffa, Pierre Aucouturier and Pierre Ronco, Membranoproliferative Glomerulonephritis, Chronic Lymphocytic Leukemia, and Cryoglobulinemia[doi.org]

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