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39 Possible Causes for Cryoglobulinemia, Epistaxis, Immunoglobulin M Increased

  • Multiple Myeloma

    Patients with a high tumor volume may present with epistaxis.[symptoma.com] In myeloma, plasma cells transform into cancerous cells and produce increased amounts of antibodies (immunoglobulins) called monoclonal proteins (M-spike), as well as incomplete[urmc.rochester.edu] Type I multiple myeloma-associated cryoglobulinemia was diagnosed.[ncbi.nlm.nih.gov]

  • Cryoimmunoglobulinemic Syndrome

    ., headache, confusion, blurry or loss of vision, hearing loss, and epistaxis ; b) deposit in small arteries and capillaries thereby plugging these blood vessels and causing[en.wikipedia.org] Figure 2 Cutaneous manifestations of mixed cryoglobulinemia (MC).[ojrd.biomedcentral.com] M. : Cryoglobulinemia and disease — Ann. intern. Med. 73 , 95, 1970. PubMed Google Scholar 2. Barr D. P., Reader G. G., Wheeler C. H. : Cryoglobulinemia.[link.springer.com]

  • Sjögren Syndrome

    Serum cryoglobulinemia was measured in all patients.[ncbi.nlm.nih.gov] Autoimmune diseases are sometimes associated with immune-mediated renal diseases and cryoglobulinemia is one of the causes.[ncbi.nlm.nih.gov] […] serological parameters that have been associated with lymphoma development in patients with Sjögren's syndrome, the presence of palpable purpura, low C4 and mixed monoclonal cryoglobulinemia[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    A 71-year-old woman presented with malaise, skin bruising, epistaxis, and gingival bleeding of recent and prompt onset. There was no adenopathy.[ncbi.nlm.nih.gov] The elevated blood viscosity in WM is the result of increased circulating serum immunoglobulin M.[ncbi.nlm.nih.gov] Type II (mixed) cryoglobulinemia is a systemic vasculitis that may affect many organs, including the skin, leading to ulcerations secondary to immune complex deposition.[ncbi.nlm.nih.gov]

  • Cryoglobulinemia

    ., headache, confusion, blurry or loss of vision, hearing loss, and epistaxis; b) deposit in small arteries and capillaries thereby plugging these blood vessels and causing[en.wikipedia.org] cryoglobulinemia.[symptoma.com] Cryoglobulinemia refers to the presence in serum of immunoglobulins that precipitate at a cold temperature.[ncbi.nlm.nih.gov]

  • Idiopathic Cryoglobulinemia

    ., headache, confusion, blurry or loss of vision, hearing loss, and epistaxis ; b) deposit in small arteries and capillaries thereby plugging these blood vessels and causing[en.wikipedia.org] […] onoclonal G ammopathy of U nknown S ignificance Long term: Increased risk of myeloma in 10 to 20 years (1% - 2%/ year) Follow-up evaluation: Test quantitative immunoglobulins[neuromuscular.wustl.edu] Key words Cryoglobulinemia basophil cells immune complexes complement This is a preview of subscription content, log in to check access.[link.springer.com]

  • Myeloproliferative Disease

    Abnormalities in platelet function lead to bleeding complications that include epistaxis, bruising, and gastrointestinal and gingival bleeding in 5% to 10% of patients. 15[clevelandclinicmeded.com] […] reactive thrombocytosis: acute hemorrhage, recovery of thrombocytopenia, infections, inflammatory diseases, tissue damage, iron deficiency, hemolytic anemia, post splenectomy, cryoglobulinemia[scielo.br] Epistaxis and ecchymosis are common. Ischemic manifestations of the central nervous system (CNS) are potentially debilitating and should be feared.[scielo.br]

  • Hyperviscosity Syndrome

    […] erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal 35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis[ncbi.nlm.nih.gov] The elevated blood viscosity in WM is the result of increased circulating serum immunoglobulin M.[ncbi.nlm.nih.gov] Hyperviscosity syndrome is much more common in monoclonal than in mixed or polyclonal cryoglobulinemia.[ncbi.nlm.nih.gov]

  • Thrombocytopenia

    It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae,[enerca.org] Immunoglobulin M titer was 6.012 UA/mL.[journals.lww.com] […] stippling Thalassemia, chronic alcohol use, lead or metal poisoning Ribosomal precipitate (appears as blue granules) throughout the cytoplasm of the red blood cell Cryoglobulin Cryoglobulinemia[aafp.org]

  • Mu-Heavy Chain Disease

    Affected individuals may rarely experience repeated nosebleeds (epistaxis).[rarediseases.org] A decrease or increase of the M-spike that is greater than 0.5 g/dL is considered a significant change.[mayomedicallaboratories.com] Neuropathy in cryoglobulinemia Primary cryoglobulinemia Secondary cryoglobulinemia Subcorneal pustular dermatosis with paraproteinemia Applies To Cryoglobulinemic: purpura[icd9data.com]

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