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115 Possible Causes for Cryoglobulinemia, Epistaxis, Oral Bleeding

  • Multiple Myeloma

    Thrombocytopenia is a frequent side effect of chemotherapy or advanced disease, increasing the risk of bleeding.[clinicaladvisor.com] Patients with a high tumor volume may present with epistaxis.[symptoma.com] Type I multiple myeloma-associated cryoglobulinemia was diagnosed.[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    A 71-year-old woman presented with malaise, skin bruising, epistaxis, and gingival bleeding of recent and prompt onset. There was no adenopathy.[ncbi.nlm.nih.gov] Type II (mixed) cryoglobulinemia is a systemic vasculitis that may affect many organs, including the skin, leading to ulcerations secondary to immune complex deposition.[ncbi.nlm.nih.gov] In most cases the first clinical features are hemorrhagic manifestations with petechiae, bruising, purpura, epistaxis, oral bleeding, bloody diarrhea and intracranial bleeding[orpha.net]

  • Hyperviscosity Syndrome

    […] erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal 35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis[ncbi.nlm.nih.gov] Hyperviscosity syndrome is much more common in monoclonal than in mixed or polyclonal cryoglobulinemia.[ncbi.nlm.nih.gov] Patients may present with any of the following: Spontaneous gum bleeding Epistaxis Rectal bleeding Menorrhagia Persistent bleeding after minor procedures Visual changes range[emedicine.medscape.com]

  • Thrombocytopenia

    Good oral care (using oral swabs, a normal saline rinse, or other mouthwash as appropriate) helps to keep mucous membranes moist and minimize bleeding.[americannursetoday.com] It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae,[enerca.org] […] stippling Thalassemia, chronic alcohol use, lead or metal poisoning Ribosomal precipitate (appears as blue granules) throughout the cytoplasm of the red blood cell Cryoglobulin Cryoglobulinemia[aafp.org]

  • Sjögren Syndrome

    In 5 female patients, non-specific ulceration or oral aphtae were observed.[ncbi.nlm.nih.gov] Serum cryoglobulinemia was measured in all patients.[ncbi.nlm.nih.gov] Autoimmune diseases are sometimes associated with immune-mediated renal diseases and cryoglobulinemia is one of the causes.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Abnormalities in platelet function lead to bleeding complications that include epistaxis, bruising, and gastrointestinal and gingival bleeding in 5% to 10% of patients. 15[clevelandclinicmeded.com] […] reactive thrombocytosis: acute hemorrhage, recovery of thrombocytopenia, infections, inflammatory diseases, tissue damage, iron deficiency, hemolytic anemia, post splenectomy, cryoglobulinemia[scielo.br] Epistaxis and ecchymosis are common. Ischemic manifestations of the central nervous system (CNS) are potentially debilitating and should be feared.[scielo.br]

  • Microscopic Polyangiitis

    They're mostly used to stop bleeding from the nose or oral cavity after minor surgery or injury and for heavy menstrual bleeding.[sharecare.com] […] with polyangiitis (GPA) by absence of granulomatous inflammation Clinical Presentation Constitutional – weight loss, fever, myalgias Otorhinolaryngological – oral ulcers, epistaxis[arupconsult.com] Patient had a flare-up consisting of bilateral episcleritis and epistaxis after discontinuing prednisone.[omicsonline.org]

  • Acquired Hemophilia A

    […] tract (nosebleeds), oral cavity (bleeding gums), urogenital tract (bloody urine) or digestive system (bloody stools).[symptoma.com] Persistent wound bleeding and epistaxis suddenly began 6 hours after surgery.[ncbi.nlm.nih.gov] Autoimmune diseases are the most frequently associated disorders and include rheumatoid arthritis, systemic lupus erythematosus, cryoglobulinemia, pemphigus vulgaris, and[ncbi.nlm.nih.gov]

  • Purpura

    The patient was treated with oral steroids. Bleeding stabilised and rash resolved. Steroids were successfully tapered.[ncbi.nlm.nih.gov] […] by extravasation of blood into the subcutaneous tissue, mucous membranes or skin; it generates bleeding manifestations as ecchymotic lesions, petechiae of sudden onset, epistaxis[ncbi.nlm.nih.gov] Cryoglobulinemia can also lead to small-vessel vasculitis, which can cause purpura. Cryoglobulins can be detected by laboratory testing.[msdmanuals.com]

  • Cryoglobulinemia

    Early enteral feeding also can decrease the incidence of bleeding.[msdmanuals.com] ., headache, confusion, blurry or loss of vision, hearing loss, and epistaxis; b) deposit in small arteries and capillaries thereby plugging these blood vessels and causing[en.wikipedia.org] cryoglobulinemia.[symptoma.com]

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