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25 Possible Causes for Cryoglobulinemia, Generalized Lymphadenopathy, Yellow Discoloration of the Skin

  • Viral Hepatitis

    HCV RNA can be demonstrated in the tumor as well as in surrounding liver tissue although HCV RNA cannot be integrated in the hepatocytic DNA. 3--Essential cryoglobulinemia[meddean.luc.edu] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org] Complications of cryoglobulinemia include rash, vasculitis, and glomerulonephritis.[emedicine.medscape.com]

  • Syphilis

    lymphadenopathy (14%), and ascites (9%).[doi.org] […] syphilis in 3 series, the most common early signs were hepatosplenomegaly (71%), rash (68%), fever (42%), neurosyphylis (23%), pneumonitis (17%), rhinitis ( snuffles ; 14%), generalized[doi.org]

  • Hepatitis B

    RESULTS: Clinical history, examinations, and laboratory results suggest HBV-associated cryoglobulinemia and vasculitis.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org] Other disorders--essential mixed cryoglobulinemia and polymyalgia rheumatica--have also been linked to HBV, but these associations are more controversial.[ncbi.nlm.nih.gov]

  • Cytomegalovirus Mononucleosis

    Lymphadenopathy is always bilateral and symmetrical in all patients, including those presenting with generalized adenopathy.[emedicine.medscape.com] This is the first report of transient pseudothrombocytopenia in CMV mononucleosis with mixed cryoglobulinemia.[ncbi.nlm.nih.gov] skin.[hopkinsmedicine.org]

  • Infectious Mononucleosis

    lymphadenopathy, including cervical lymphadenopathy tonsillar enlargement possible hepatomegaly Treatment and prognosis Symptomatic therapy is usually sufficient.[radiopaedia.org] Arima, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Hiroyuki Moriuchi and Atsushi Kawakami, An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia[oadoi.org] skin.[hopkinsmedicine.org]

  • Hepatitis A

    Signs include hepatomegaly, lymphadenopathy and splenomegaly, though these findings vary from individual to individual, depending on general health status and age group.[symptoma.com] Transverse myelitis Renal findings Acute tubular necrosis Interstitial nephritis Mesangial proliferative glomerulonephritis Nephrotic syndrome Other findings Cutaneous vasculitis Cryoglobulinemia[aafp.org] The most common symptoms are as follows: Nausea Vomiting Diarrhea, especially in children Low-grade fever Loss of appetite Rash Tiredness, fatigue Jaundice - A yellow discoloration[web.archive.org]

  • Cytomegalovirus

    When clinical manifestations are present, they include: malaise, fever, generalized lymphadenopathy, and hepatosplenomegaly.[perinatology.com] Laboratory tests that may be rendered falsely positive from acute CMV infection include rheumatoid factor, positive direct Coombs', polyclonal hypergammaglobulinemia, cryoglobulinemia[aafp.org] Hepatitis B can cause inflammation of the liver, and in the earliest stage of the disease, infected people may feel ill or even have yellow discoloration of the skin or eyes[web.archive.org]

  • Hepatitis E

    Type II cryoglobulinemia with monoclonal immunoglobulin G (IgG) κ light chain was detected.[ncbi.nlm.nih.gov] Typical signs and symptoms of hepatitis include jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools), anorexia (loss of appetite)[hepfi.org] Guillain-Barré syndrome, neuralgic amyotrophy, hemolytic anemia due to glucose phosphate dehydrogenase deficiency, severe thrombocytopenia, glomerulonephritis, and mixed cryoglobulinemia[ncbi.nlm.nih.gov]

  • Cold Agglutinin Disease

    Abdominal ultrasound or CT scan if suspected hepato/splenomegaly or lymphadenopathy is detected.[patient.info] Rituximab therapy has been found to be effective in mixed cryoglobulinemia, with decreases in cryoglobulin values and improvement in complement values.[ncbi.nlm.nih.gov] Some people experience fatigue and jaundice yellowing of the skin and/or the whites of the eyes.[sunridgemedical.com]

  • Chilblain Lupus Erythematosus

    Vitiligo-like depigmentation 58. 5% DLE SLE Risk factors for the development of SLE: • diffuse nonscarring alopecia; • generalized lymphadenopathy; • periungual nail fold[slideshare.net] Because of occasional false-negative cryoprecipitate screening results, consider hepatitis C antibody screening or even rheumatoid factor (RF) as a marker for cryoglobulinemia[dermaamin.com] It may cuase yellow discoloration of the skin.[dermatologyadvisor.com]

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