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52 Possible Causes for Cryoglobulinemia, Hepatomegaly, Yellow Discoloration of the Skin

  • Viral Hepatitis

    Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] HCV RNA can be demonstrated in the tumor as well as in surrounding liver tissue although HCV RNA cannot be integrated in the hepatocytic DNA. 3--Essential cryoglobulinemia[meddean.luc.edu] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org]

  • Chronic Hepatitis C

    Approximately 80% of patients with hepatitis C virus infection develop chronic liver disease as cirrhosis, and 40% develop autoimmune complications as mixed cryoglobulinemia[ncbi.nlm.nih.gov] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org] Inflammation leads to the enlargement of the liver (hepatomegaly) in over 60% of people infected with hepatitis C and can cause the fibroelastic sheath (Glisson’s capsule)[hepctrust.org.uk]

  • Hepatitis B

    RESULTS: Clinical history, examinations, and laboratory results suggest HBV-associated cryoglobulinemia and vasculitis.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org] Other disorders--essential mixed cryoglobulinemia and polymyalgia rheumatica--have also been linked to HBV, but these associations are more controversial.[ncbi.nlm.nih.gov]

  • Hepatitis C

    Additional symptoms are non-specific and may comprise hepatomegaly, upper abdominal pain, nausea, vomiting and loss of appetite.[symptoma.com] Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia.[doi.org] Signs and symptoms include: Bleeding easily Bruising easily Fatigue Poor appetite Yellow discoloration of the skin and eyes (jaundice) Dark-colored urine Itchy skin Fluid[mayoclinic.org]

  • Infectious Mononucleosis

    Arima, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Hiroyuki Moriuchi and Atsushi Kawakami, An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia[dx.doi.org] skin.[hopkinsmedicine.org] The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov]

  • Liver Cirrhosis

    Cardinal symptoms include fasting hypoglycemia, lactic acidosis and hepatomegaly as well as neutropenia.[ncbi.nlm.nih.gov] […] non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis, where the intermediated mixed cryoglobulinemia[ncbi.nlm.nih.gov] Yellow discoloration in the skin and eyes (jaundice) Fluid accumulation in your abdomen (ascites) Spiderlike blood vessels on your skin Redness in the palms of the hands[mayoclinic.org]

  • Hepatitis

    Findings include: hepatomegaly 15.5 cm at the midclavicular line 4 possible decreased attenuation around the portal system and at the hepatic hilum (periportal edema) possible[radiopaedia.org] […] mellitus, which occurs three times more frequently in HCV-infected persons; glomerulonephritis, a type of kidney disease caused by inflammation of the kidney; essential mixed cryoglobulinemia[patients.gi.org] A hepatitis infection is also associated with jaundice, a yellow discoloration of the skin and a yellowish color to the whites of the eyes.[healthychildren.org]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[radiopaedia.org] cryoglobulinemia is more common.[merckmanuals.com] discoloration of the skin and the whites of the eyes ( jaundice ).[labtestsonline.org]

  • Liver Disease

    CASE REPORT In 1979, CESD was first diagnosed in a 13-year-old female with marked hepatomegaly.[ncbi.nlm.nih.gov] Keratoconjunctivitis (sicca syndrome), glomerulonephritis, skin disorders (for example, lichen planus, porphyria cutanea tarda), neuropathy, and immune dysfunction (for example, cryoglobulinemia[ssa.gov] Symptoms of liver diseases include weakness and fatigue, weight loss, nausea, vomiting, and yellow discoloration of the skin (jaundice).[medicinenet.com]

  • Hepatitis A

    Transverse myelitis Renal findings Acute tubular necrosis Interstitial nephritis Mesangial proliferative glomerulonephritis Nephrotic syndrome Other findings Cutaneous vasculitis Cryoglobulinemia[web.archive.org] The most common symptoms are as follows: Nausea Vomiting Diarrhea, especially in children Low-grade fever Loss of appetite Rash Tiredness, fatigue Jaundice - A yellow discoloration[web.archive.org] The child was deeply icteric and had hepatomegaly. IgM antibodies for hepatitis A virus were positive.[ncbi.nlm.nih.gov]

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