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46 Possible Causes for Cryoglobulinemia, Hepatosplenomegaly, Yellow Discoloration of the Skin

  • Viral Hepatitis

    Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] HCV RNA can be demonstrated in the tumor as well as in surrounding liver tissue although HCV RNA cannot be integrated in the hepatocytic DNA. 3--Essential cryoglobulinemia[meddean.luc.edu] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org]

  • Hepatitis B

    It is similar to chronic liver disease because of signs and symptoms such as fever, weight loss, hepatosplenomegaly, and pancytopenia.[ncbi.nlm.nih.gov] RESULTS: Clinical history, examinations, and laboratory results suggest HBV-associated cryoglobulinemia and vasculitis.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org]

  • Syphilis

    Among 139 infants with symptomatic congenital syphilis in 3 series, the most common early signs were hepatosplenomegaly (71%), rash (68%), fever (42%), neurosyphylis (23%)[doi.org]

  • Hepatitis C

    Jaundice, hepatosplenomegaly, ascites, encephalopathy and gastroesophageal varices are signs of more advanced disease.[doi.org] Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia.[doi.org] Signs and symptoms include: Bleeding easily Bruising easily Fatigue Poor appetite Yellow discoloration of the skin and eyes (jaundice) Dark-colored urine Itchy skin Fluid[mayoclinic.org]

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] Arima, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Hiroyuki Moriuchi and Atsushi Kawakami, An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia[dx.doi.org] skin.[hopkinsmedicine.org]

  • Chronic Hepatitis C

    Jaundice, hepatosplenomegaly, ascites, encephalopathy and gastroesophageal varices are signs of more advanced disease.[doi.org] Approximately 80% of patients with hepatitis C virus infection develop chronic liver disease as cirrhosis, and 40% develop autoimmune complications as mixed cryoglobulinemia[ncbi.nlm.nih.gov] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org]

  • Hepatitis A

    On examination, he had tachypnea, hepatosplenomegaly, ascites and right-sided pleural effusion.[ncbi.nlm.nih.gov] Transverse myelitis Renal findings Acute tubular necrosis Interstitial nephritis Mesangial proliferative glomerulonephritis Nephrotic syndrome Other findings Cutaneous vasculitis Cryoglobulinemia[web.archive.org] The most common symptoms are as follows: Nausea Vomiting Diarrhea, especially in children Low-grade fever Loss of appetite Rash Tiredness, fatigue Jaundice - A yellow discoloration[web.archive.org]

  • Cold Agglutinin Disease

    Symptoms during hemolytic crises'' may include severe pain in the back and legs, headache, vomiting, diarrhea, dark urine and hepatosplenomegaly.[web.archive.org] Rituximab therapy has been found to be effective in mixed cryoglobulinemia, with decreases in cryoglobulin values and improvement in complement values.[ncbi.nlm.nih.gov] Some people experience fatigue and jaundice yellowing of the skin and/or the whites of the eyes.[sunridgemedical.com]

  • Cytomegalovirus Mononucleosis

    The patient was a young woman with fever that had persisted for 24 days, and with relative bradycardia, hepatosplenomegaly, suboccipital lymphadenopathy and a rash.[ncbi.nlm.nih.gov] This is the first report of transient pseudothrombocytopenia in CMV mononucleosis with mixed cryoglobulinemia.[ncbi.nlm.nih.gov] skin.[hopkinsmedicine.org]

  • Autoimmune Disease

    RALD was diagnosed in an 11-year-old girl following a 9-year history of severe hepatosplenomegaly and autoimmune cytopenias.[ncbi.nlm.nih.gov] Autoimmune diseases are the most frequently associated disorders and include rheumatoid arthritis, systemic lupus erythematosus, cryoglobulinemia, pemphigus vulgaris, and[ncbi.nlm.nih.gov] In severe cases the individual can develop a yellow discoloration to the skin and eyes known as jaundice.[primaryimmune.org]

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