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17 Possible Causes for Cryoglobulinemia, Hyperglobulinemia, Yellow Discoloration of the Skin

  • Chronic Hepatitis C

    Approximately 80% of patients with hepatitis C virus infection develop chronic liver disease as cirrhosis, and 40% develop autoimmune complications as mixed cryoglobulinemia[ncbi.nlm.nih.gov] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org] […] hepatitis C virus infection who developed pulmonary extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissues complicated with macroglobulinemia and mixed cryoglobulinemia[ncbi.nlm.nih.gov]

  • Viral Hepatitis

    HCV RNA can be demonstrated in the tumor as well as in surrounding liver tissue although HCV RNA cannot be integrated in the hepatocytic DNA. 3--Essential cryoglobulinemia[meddean.luc.edu] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org] Complications of cryoglobulinemia include rash, vasculitis, and glomerulonephritis.[emedicine.medscape.com]

  • Hepatitis B

    RESULTS: Clinical history, examinations, and laboratory results suggest HBV-associated cryoglobulinemia and vasculitis.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org] Other disorders--essential mixed cryoglobulinemia and polymyalgia rheumatica--have also been linked to HBV, but these associations are more controversial.[ncbi.nlm.nih.gov]

  • Syphilis

    Syphilis is a sexually transmitted disease that can affect multiple organ systems, with central nervous system involvement at any stage. We present a 53-year-old woman with an unusual truncal rash with painful anogenital lesions, accompanied by patchy alopecia, oral lesions, photophobia and hoarseness. She was found[…][ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    Arima, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Hiroyuki Moriuchi and Atsushi Kawakami, An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia[dx.doi.org] skin.[hopkinsmedicine.org] discoloration of the skin and whites of the eyes due to abnormally high levels of bilirubin (bile pigmentation) in the bloodstream Once a person has had mononucleosis, the[hopkinsmedicine.org]

  • Nephrotic Syndrome

    Amyloidosis and cryoglobulinemia were ruled out.[casesjournal.biomedcentral.com] […] children, but more common in older adults with underlying artherosclerosis Treatment of the proteinuria resolves the AKI Treatment: prednisone over 8 weeks Essential mixed cryoglobulinemia[errolozdalga.com] […] streptococci) Collagen-vascular disease Lupus nephritis Henoch-Schönlein purpura (immunoglobulin A and systemic vasculitis) Immunoglobulin A nephropathy (no vasculitis) Mixed cryoglobulinemia[emedicine.medscape.com]

  • Liver Disease

    Keratoconjunctivitis (sicca syndrome), glomerulonephritis, skin disorders (for example, lichen planus, porphyria cutanea tarda), neuropathy, and immune dysfunction (for example, cryoglobulinemia[ssa.gov] Symptoms of liver diseases include weakness and fatigue, weight loss, nausea, vomiting, and yellow discoloration of the skin (jaundice).[medicinenet.com] Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia. J Immunol. 1998; 160: 3594-601 40.[doi.org]

  • Hepatitis A

    Transverse myelitis Renal findings Acute tubular necrosis Interstitial nephritis Mesangial proliferative glomerulonephritis Nephrotic syndrome Other findings Cutaneous vasculitis Cryoglobulinemia[web.archive.org] The most common symptoms are as follows: Nausea Vomiting Diarrhea, especially in children Low-grade fever Loss of appetite Rash Tiredness, fatigue Jaundice - A yellow discoloration[web.archive.org] A hepatitis infection is also associated with jaundice, a yellow discoloration of the skin and a yellowish color to the whites of the eyes.[healthychildren.org]

  • Hepatitis E

    Type II cryoglobulinemia with monoclonal immunoglobulin G (IgG) κ light chain was detected.[ncbi.nlm.nih.gov] Typical signs and symptoms of hepatitis include jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools), anorexia (loss of appetite)[hepfi.org] Guillain-Barré syndrome, neuralgic amyotrophy, hemolytic anemia due to glucose phosphate dehydrogenase deficiency, severe thrombocytopenia, glomerulonephritis, and mixed cryoglobulinemia[ncbi.nlm.nih.gov]

  • Liver Cirrhosis

    Significance of hyperglobulinemia in severe chronic liver diseases--with special reference to the correlation between serum globulin/IgG level and ICG clearance.[ncbi.nlm.nih.gov] […] non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis, where the intermediated mixed cryoglobulinemia[ncbi.nlm.nih.gov] Yellow discoloration in the skin and eyes (jaundice) Fluid accumulation in your abdomen (ascites) Spiderlike blood vessels on your skin Redness in the palms of the hands[mayoclinic.org]

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