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44 Possible Causes for Cryoglobulinemia, Splenomegaly, Yellow Discoloration of the Skin

  • Viral Hepatitis

    HCV RNA can be demonstrated in the tumor as well as in surrounding liver tissue although HCV RNA cannot be integrated in the hepatocytic DNA. 3--Essential cryoglobulinemia[meddean.luc.edu] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org] Complications of cryoglobulinemia include rash, vasculitis, and glomerulonephritis.[emedicine.medscape.com]

  • Hepatitis B

    CASE REPORT: A 29-year-old man, with no significant prior medical history, presented with fever and massive splenomegaly.[ncbi.nlm.nih.gov] RESULTS: Clinical history, examinations, and laboratory results suggest HBV-associated cryoglobulinemia and vasculitis.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org]

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Arima, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Hiroyuki Moriuchi and Atsushi Kawakami, An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia[oadoi.org] skin.[hopkinsmedicine.org]

  • Liver Cirrhosis

    We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] […] non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis, where the intermediated mixed cryoglobulinemia[ncbi.nlm.nih.gov] Yellow discoloration in the skin and eyes (jaundice) Fluid accumulation in your abdomen (ascites) Spiderlike blood vessels on your skin Redness in the palms of the hands[mayoclinic.org]

  • Hepatitis

    Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly and Splenomegaly[symptoma.com] […] mellitus, which occurs three times more frequently in HCV-infected persons; glomerulonephritis, a type of kidney disease caused by inflammation of the kidney; essential mixed cryoglobulinemia[patients.gi.org] A hepatitis infection is also associated with jaundice, a yellow discoloration of the skin and a yellowish color to the whites of the eyes.[healthychildren.org]

  • Chronic Hepatitis C

    Three patients had pre-treatment hematological abnormalities related to splenomegaly.[ncbi.nlm.nih.gov] Approximately 80% of patients with hepatitis C virus infection develop chronic liver disease as cirrhosis, and 40% develop autoimmune complications as mixed cryoglobulinemia[ncbi.nlm.nih.gov] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org]

  • Cold Agglutinin Disease

    PET/CT revealed splenomegaly with focally intense uptake of F-FDG and diffusely increased bone marrow uptake, which was considered to be secondary to hemolytic anemia.[ncbi.nlm.nih.gov] Rituximab therapy has been found to be effective in mixed cryoglobulinemia, with decreases in cryoglobulin values and improvement in complement values.[ncbi.nlm.nih.gov] Some people experience fatigue and jaundice yellowing of the skin and/or the whites of the eyes.[sunridgemedical.com]

  • Cytomegalovirus

    Hemophagocytic lymphohistiocytosis was diagnosed because our patient had elevated levels of serum ferritin, bicytopenia, splenomegaly, fever (  38.5 C), and hemophagocytosis[ncbi.nlm.nih.gov] Laboratory tests that may be rendered falsely positive from acute CMV infection include rheumatoid factor, positive direct Coombs', polyclonal hypergammaglobulinemia, cryoglobulinemia[aafp.org] Hepatitis B can cause inflammation of the liver, and in the earliest stage of the disease, infected people may feel ill or even have yellow discoloration of the skin or eyes[web.archive.org]

  • Syphilis

    Symptoms include hepatomegaly, splenomegaly and pemphigus syphiliticus. In the late stage, symptoms occur after more than 4 years from birth.[flexikon.doccheck.com] Less common presentations include patchy alopecia, anterior uveitis, meningitis, cranial nerve palsies, hepatitis, splenomegaly, periostitis and glomerulonephritis.[patient.info]

  • Hepatitis A

    Tender hepatomegaly, splenomegaly, and lymphadenopathy may occur.[patient.info] Transverse myelitis Renal findings Acute tubular necrosis Interstitial nephritis Mesangial proliferative glomerulonephritis Nephrotic syndrome Other findings Cutaneous vasculitis Cryoglobulinemia[aafp.org] The most common symptoms are as follows: Nausea Vomiting Diarrhea, especially in children Low-grade fever Loss of appetite Rash Tiredness, fatigue Jaundice - A yellow discoloration[web.archive.org]

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