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64 Possible Causes for Cryoglobulinemia, Yellow Discoloration of the Skin

  • Chronic Hepatitis C

    Approximately 80% of patients with hepatitis C virus infection develop chronic liver disease as cirrhosis, and 40% develop autoimmune complications as mixed cryoglobulinemia[ncbi.nlm.nih.gov] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org] […] hepatitis C virus infection who developed pulmonary extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissues complicated with macroglobulinemia and mixed cryoglobulinemia[ncbi.nlm.nih.gov]

  • Viral Hepatitis

    HCV RNA can be demonstrated in the tumor as well as in surrounding liver tissue although HCV RNA cannot be integrated in the hepatocytic DNA. 3--Essential cryoglobulinemia[meddean.luc.edu] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org] Complications of cryoglobulinemia include rash, vasculitis, and glomerulonephritis.[emedicine.medscape.com]

  • Hepatitis B

    RESULTS: Clinical history, examinations, and laboratory results suggest HBV-associated cryoglobulinemia and vasculitis.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org] Other disorders--essential mixed cryoglobulinemia and polymyalgia rheumatica--have also been linked to HBV, but these associations are more controversial.[ncbi.nlm.nih.gov]

  • Syphilis

    Syphilis is a sexually transmitted disease that can affect multiple organ systems, with central nervous system involvement at any stage. We present a 53-year-old woman with an unusual truncal rash with painful anogenital lesions, accompanied by patchy alopecia, oral lesions, photophobia and hoarseness. She was found[…][ncbi.nlm.nih.gov]

  • Autoimmune Disease

    Autoimmune diseases are the most frequently associated disorders and include rheumatoid arthritis, systemic lupus erythematosus, cryoglobulinemia, pemphigus vulgaris, and[ncbi.nlm.nih.gov] In severe cases the individual can develop a yellow discoloration to the skin and eyes known as jaundice.[primaryimmune.org] Celiac Disease Multifocal Motor Neuropathy (MNN) Peripheral Neuropathy Associated with Protein Abnormalities Anti-MAG (associated with Monoclonal Gammopathy) Amyloidosis Cryoglobulinemia[foundationforpn.org]

  • Hepatitis C

    Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia.[doi.org] Signs and symptoms include: Bleeding easily Bruising easily Fatigue Poor appetite Yellow discoloration of the skin and eyes (jaundice) Dark-colored urine Itchy skin Fluid[mayoclinic.org] discoloration in the skin and eyes (jaundice) Fever Muscle and joint pains How long after infection do symptoms appear?[health.utah.gov]

  • Cold Agglutinin Disease

    Rituximab therapy has been found to be effective in mixed cryoglobulinemia, with decreases in cryoglobulin values and improvement in complement values.[ncbi.nlm.nih.gov] Some people experience fatigue and jaundice yellowing of the skin and/or the whites of the eyes.[sunridgemedical.com] To present a case of cold agglutinin disease/cryoglobulinemia secondary to a monoclonal anti-Pr2 IgM lambda antibody, and review the literature on the occurrence of this antibody[ncbi.nlm.nih.gov]

  • Cytomegalovirus Mononucleosis

    This is the first report of transient pseudothrombocytopenia in CMV mononucleosis with mixed cryoglobulinemia.[ncbi.nlm.nih.gov] skin.[hopkinsmedicine.org] Laboratory tests that may be rendered falsely positive from acute CMV infection include rheumatoid factor, positive direct Coombs', polyclonal hypergammaglobulinemia, cryoglobulinemia[aafp.org]

  • Liver Cirrhosis

    […] non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis, where the intermediated mixed cryoglobulinemia[ncbi.nlm.nih.gov] Yellow discoloration in the skin and eyes (jaundice) Fluid accumulation in your abdomen (ascites) Spiderlike blood vessels on your skin Redness in the palms of the hands[mayoclinic.org] […] infrequently, patients with cirrhosis experience neuropathic pain due to neuropathies from a variety of causes, including diabetes, alcoholism, nutrient deficiencies, and cryoglobulinemia[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    Arima, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Hiroyuki Moriuchi and Atsushi Kawakami, An elderly patient with chronic active Epstein–Barr virus infection with mixed cryoglobulinemia[dx.doi.org] skin.[hopkinsmedicine.org] discoloration of the skin and whites of the eyes due to abnormally high levels of bilirubin (bile pigmentation) in the bloodstream Once a person has had mononucleosis, the[hopkinsmedicine.org]

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