Cryptococcus Antigen: Causes & Reasons

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Possible Causes for Cryptococcus Antigen

Cryptococcal Meningitis

Five days later, the CSF was positive for Cryptococcus antigen. We administered amphotericin B and flucytosine, followed by fluconazole. [ncbi.nlm.nih.gov]

Cryptococcal meningitis was confirmed by lumbar puncture with positive cryptococcus antigen in the cerebrospinal fluid. [ncbi.nlm.nih.gov]

The diagnosis of cryptococcal meningitis was obtained later on by simultaneous plasma and CSF Cryptococcus antigen detection. [ncbi.nlm.nih.gov]

Pulmonary Cryptococcosis

Furthermore, the serum cryptococcus antigen was negative. Therefore, thoracoscopic partial lung resection was performed. [ncbi.nlm.nih.gov]

The titer of Cryptococcus antigen latex agglutination test was 1:1,280. [ncbi.nlm.nih.gov]

Cytology of the bronchial lavage showed a small number of Periodic acid-Schiff-positive bodies, suggesting Cryptococcus species. [ncbi.nlm.nih.gov]

Cryptococcosis

Cryptococcal capsular polysaccharide antigen test of the CSF or serum was conducted using the latex-Cryptococcus antigen detection system (Immuno-Mycologics, Inc., USA). [bmcinfectdis.biomedcentral.com]

In addition to testing for cryptococcal antigen, patients with presumed disease due to Cryptococcus neoformans should have clinical specimens (eg, bronchoalveolar lavage fluid [mayomedicallaboratories.com]

- Detection of Cryptococcus neoformans antigen in body fluids by latex particle agglutination. Proc. Soc. exp. biol. Med., 114: 64-67, 1963. [ Links ] 5. [scielo.br]

Disseminated Cryptococcosis

Laboratory data revealed CD4 lymphocytopenia and a tissue culture of the skin nodule was positive for Cryptococcus neoformans. [ncbi.nlm.nih.gov]

Titers of Cryptococcus neoformans capsular antigen in CSF > or = 1/1000 were found in 36.1 and > or = 1/1000 in 73.6 of serum samples. [bases.bireme.br]

antigen titer of 1:32). [ncbi.nlm.nih.gov]

AIDS-Associated Meningoencephalitis

[…] testing if resources allow. [ 6 ] Cryptococcus antigen testing is an alternative to the India ink for the diagnosis of cryptococcal meningitis. [ 7 ] Cryptococcus antigen [pubs.sciepub.com]

Both in serum and CSF, the antigen titre was done. Antigen titre in serum was 132 and in CSF it was more than 32. [ijmm.org]

The blood or spinal fluid can be tested for cryptococcus in two ways. A “CRAG” test looks for an antigen (a protein) produced by cryptococcus. [aidsinfonet.org]

Primary Central Nervous System Vasculitis

Additional CSF tests with negative results included the venereal disease research laboratory test, Cryptococcus antigen test, fungal and bacterial cultures, and polymerase [the-rheumatologist.org]

antigen, HSV 1,2 HIV 1,2 Epstein–Barr virus (EBV), West Nile, venereal disease research laboratory, varizella zoster, and Borrelia burgdorferi. [surgicalneurologyint.com]

[…] lobe on sagittal section A lumbar puncture was performed, which was negative for an infectious etiology including routine, acid-fast bacilli (AFB), and fungal cultures, cryptococcus [surgicalneurologyint.com]

Factitious Fever

antigen, histoplasmosis, coccidioidomycosis) • Protozoal and parasitic (toxoplasmosis, amoebiasis, schistosomiasis, leishmaniasis, trypanosomiasis) • PCR e.g for tuberculosis [studyslide.com]

Bacterial (chlamydial infection, Q fever, brucellosis, mycoplasma infection, syphilis, leptospirosis, Lyme disease, Yersinia infection, streptococcal infection) • Fungal(Cryptococcus [studyslide.com]

Histoplasma Meningitis

There appears to be no cross-reactivity between Cryptococcus neoformans and Histoplasma antigen testing, and cryptococcosis appears to be at most, a rare cause of positive [experts.umn.edu]

Mobility of human neutrophils in response to Cryptococcus neoformans cells, culture filtrate antigen, and individual components of the antigen. [wwwnc.cdc.gov]

Rapid clearance of Candida albicans mannan antigens by liver and spleen in contrast to prolonged circulation of Cryptococcus neoformans antigens. [neurologyindia.com]

Cryptococcus Neoformans

Plasma and CSF samples were tested by both real time PCR and the Cryptococcus antigen (CrAg) lateral flow assay (LFA) (IMMY Inc., Norman, Oklahoma). [nature.com]

Cryptococcus neoformans can be sub-typed further based on serological response to capsular antigens. [thunderhouse4-yuri.blogspot.com]

Mukjerjee S, Casadevall A (1995) Sensitivy sandwich enzyme-linked immunosorbent assay for Cryptococcus neoformans polysaccharide antigen is dependent on the isotype of the [mycology.imedpub.com]

Chronic Meningitis

On serum examinations, Cryptococcus neoformans antigen was negative, Candida antigen level was 4 times the normal value (normal range, <2), and Aspergillus antigen level was [hindawi.com]

For example, tests may be done to detect proteins released by Cryptococcus neoformans (called antigen testing). [merckmanuals.com]

Obstructive Hydrocephalus

The diagnosis of cryptococcal meningitis was obtained later on by simultaneous plasma and CSF Cryptococcus antigen detection. [ncbi.nlm.nih.gov]

Cryptococcus neoformans (formerly C. neoformans var. grubii [serotype A]) was then identified by PCR. Clinical improvement was obtained with antifungal therapy. [ncbi.nlm.nih.gov]

Choroiditis

CSF confirmed cryptococcus by India ink preparation and antigen by latex agglutination. [ncbi.nlm.nih.gov]

Cryptococcal meningitis was confirmed by a cerebrospinal fluid (CSF) positive India ink stain, latex-Cryptococcus antigen detection (IMMY Mycologics Inc., OK, USA) positive [elsevier.es]

Peripheral blood cultures grew Cryptococcus neoformans. [retinalphysician.com]

Lymphopenia

antigens in screening tests; and 3) up to 60% false negative serology in patients with local atypical fungal infection (i.e., blastomycosis). [cytojournal.com]

Gram stain of CSF showed yeast suggestive of Cryptococcus. HSV, Enterovirus, VDRL were negative. The CSF cryptococcal antigen returned with a positive result of >1:1024. [omicsonline.org]

[…] as: 1) malignancy as the diagnosis of exclusion atypical fungal infections presenting with multi organ "mass" lesions; 2) 80% cross reactivity with both Histoplasma and Cryptococcus [cytojournal.com]

Giant-Cell Granulomatous Hypophysitis

antigen, HSV 1,2 HIV 1,2 Epstein–Barr virus (EBV), West Nile, venereal disease research laboratory, varizella zoster, and Borrelia burgdorferi. [surgicalneurologyint.com]

Primary Amebic Meningoencephalitis

CSF for the agglutination test for Cryptococcus antigen was also negative. [ncbi.nlm.nih.gov]

Spp. seen No Cryptococcus Spp. seen No Cryptococcus Spp. seen Cryptococcal Antigen Test Non-Reactive Non-Reactive Non-Reactive CSF Culture No growth No growth No growth Direct [bmcinfectdis.biomedcentral.com]

(82% neutrophils) 200/mm 3 (90% neutrophils) Red blood cells 5250/mm 3 820 /mm 3 5000/mm 3 Gram Stain No organisms seen No organisms seen No organisms seen Indian Ink No Cryptococcus [bmcinfectdis.biomedcentral.com]

Spinal Puncture

antigen assays, India ink stains, angiotensin-converting enzyme (ACE) levels, or other studies are ordered. [emedicine.medscape.com]

Persistently elevated CSF cryptococcal antigen in HIV-infected patients carries a poor prognosis and indicates ongoing production of viable Cryptococcus neoformans in tissue [doi.org]

The India ink test is still used for detection of meningitis caused by Cryptococcus neoformans, but the cryptococcal antigen (CrAg) test has a higher sensitivity. [house.wikia.com]

Cerebral Angiitis

antigen, HSV 1,2 HIV 1,2 Epstein–Barr virus (EBV), West Nile, venereal disease research laboratory, varizella zoster, and Borrelia burgdorferi. [surgicalneurologyint.com]

Autoimmune Hepatitis

Urine histoplasma and Cryptococcus antigens were negative. Anti-nuclear, anti-smooth muscle, anti-LKM and anti-mitochondrial antibodies were negative. [bloodjournal.org]

Viral Meningitis

Coccidioides antibody CCOCCI 4 3 Cryptococcus antigen CRAGC 1 0.5 cytology CCSF 1 Cannot be split for other tests. Left over from other CSF samples cannot be used. [wiki.umms.med.umich.edu]

Other studies can include acid-fast stain and tuberculosis PCR/Culture, VDRL, and antigen testing for cryptococcus. [emlyceum.com]

If suspecting cryptococcal meningitis, a specimen should also be submitted for cryptococcus antigen screen. Do not refridgerate as this can inhibit Histoplasma growth. [wiki.umms.med.umich.edu]

Systemic Mycosis

Particularly useful tests include the following: Measurement of organism-specific antigens, most notably from Cryptococcus neoformans, Histoplasma capsulatum, and Aspergillus [merckmanuals.com]

Septic Embolus

Blood and urine cultures grew methicillin-resistant Staphylococcus aureus, CD4 count was 180, cryptococcus and histoplasma antigens were negative, as were urine antigens for [swjpcc.com]

Chronic Hepatitis C

Five days later, the CSF was positive for Cryptococcus antigen. We administered amphotericin B and flucytosine, followed by fluconazole. [ncbi.nlm.nih.gov]

The cerebral spinal fluid (CSF) revealed a white blood cell count of 205/mm(3), 51 mg/dL protein, 35 mg/dL glucose, and negative Cryptococcus antigen. [ncbi.nlm.nih.gov]

Lymphadenitis

Serological detection of cryptococcus antigens by latex agglutination and culture are also used. [atmph.org]

Meningoencephalitis

[…] of Cryptococcus. [ncbi.nlm.nih.gov]

The CSF cryptococcal antigen test was not repeated. The blood that had been collected upon admission was microbiologically negative. [bmcresnotes.biomedcentral.com]

Diagnosis of central nervous system cryptococcosis relies on a spectrum of methods but has improved with lateral flow diagnostic assays that detect capsular polysaccharide antigens [ncbi.nlm.nih.gov]

Listerial Meningitis

PCR for tuberculosis, the herpes simplex virus antibody test, the co-agglutination test, and cryptococcus antigen test were all negative. [ncbi.nlm.nih.gov]

West Nile Encephalitis

Herpes Simplex Virus-1 (HSV-1) and HSV-2 reverse transcription-polymerase chain reaction (RT-PCR) tests were negative, as was Cryptococcus neoformans antigen. [hindawi.com]

Flucytosine

The microbiology study showed staining and a positive culture for Cryptococcus neoformans, and an antigen titre of 1/2080. [ncbi.nlm.nih.gov]

antigen titer of 1:32). [ncbi.nlm.nih.gov]

We report a 66-year-old liver transplant recipient with disseminated invasive cryptococcus (presenting as cryptococcal subcutaneous abscess, osteomyelitis, and serum cryptococcal [ncbi.nlm.nih.gov]

Subcutaneous Abscess

After surgical incision and drainage was performed, Cryptococcus neoformans var. neoformans was the only pathogen cultured from the lesion. [thieme-connect.com]

Cryptococcal polysaccharide antigen in serum and cerebrospinal fluid (CSF) were positive at titers 1:1280 and 1:16, respectively. Blood and CSF cultures were negative. [ijdvl.com]

An agglutination test for the capsular antigen in serum displayed negative results and the immunological work-up revealed no underlying immunodeficiency. [thieme-connect.com]

Lyme Meningoencephalitis

For example, tests may be done to detect proteins released by Cryptococcus neoformans (called antigen testing). [merckmanuals.com]

Disseminated Toxoplasmosis

The cryptococcus antigen was negative. Treatment against mycobacteria was performed with four drugs and endovenous steroids, as disseminated tuberculosis was suspected. [acmicrob.com]