Cryptorchidism: Causes & Reasons

Possible Causes for Cryptorchidism

Occasionally the diagnosis is made earlier due to investigation of other associated anomalies, including: midline defects (e.g. cleft lip and palate) cryptorchidism renal [radiopaedia.org]

[…] with cryptorchidism uniformly. [ncbi.nlm.nih.gov]

The final diagnosis was made only when they were aged between 17 and 26 (mean 21 years), although they had been seen by several physicians before: 3 for cryptorchidism and [nature.com]

Hypogonadotropic Hypogonadism

We carried out a Pubmed search with the keywords “cryptorchidism”, “cryptorchid testes”, “testes descent”, “CHH”, “CPHD”, “hypopituitarism”, “Kallman”, “isolated HH or idiopathic [ijpeonline.biomedcentral.com]

SUMMARY ANSWER: A multitude of different diagnoses underlie DP, and in boys a history of cryptorchidism, small testicular size and slow growth velocity (GV) predict its clinical [ncbi.nlm.nih.gov]

We report a male neonate with no family history of reproductive disorders who was born with micropenis and cryptorchidism. [ncbi.nlm.nih.gov]

Aarskog-Scott Syndrome

Aarskog syndrome is characterised by a disproportionately short stature and facial, skeletal and urogenital anomalies ('shawl' scrotum and cryptorchidism). [ncbi.nlm.nih.gov]

Genitourinary Manifestations 'shawl' scrotum (80%) cryptorchidism (75%) inguinal hernia (60%) 3. [web.archive.org]

Aarskog syndrome (faciogenital dysplasia) is a genetic growth disorder characterized by short stature, cryptorchidism, shawl scrotum, and dysmorphic facial features. [ncbi.nlm.nih.gov]

Patau Syndrome

Genitals are frequently abnormal in both sexes; cryptorchidism and an abnormal scrotum occur in boys, and a bicornuate uterus occurs in girls. [merckmanuals.com]

The major clinical findings include cryptorchidism, abnormal auricles, congenital heart defects, polydactyly, microphthalmia, and micrognathia. [genome.jp]

King Syndrome

Considering the severity and the high rate of lethality of a MH reaction, as children with KDS are likely to undergo surgery with general anes- thesia for cryptorchidism and [idocslide.com]

In 1973, King described a subgroup of malignant hyperthermia patients with slowly progressive myopathy, short stature, kyphoscoliosis, pectus carinatum, cryptorchidism, and [ncbi.nlm.nih.gov]

We report a case of King's syndrome without the cryptorchidism and pectus carinatum associated with the syndrome. [jamanetwork.com]

Noonan Syndrome

Despite the fact that cryptorchid patients had significant lower AMH levels compared with healthy children, no difference was found between cryptorchid and non-cryptorchid [eje.bioscientifica.com]

Males: cryptorchidism (70-80%), infertility. [pedclerk.bsd.uchicago.edu]

Boys frequently present with cryptorchidism and manifest delayed puberty. [bestpractice.bmj.com]

Denys-Drash Syndrome

[…] and hypospadias 8 HD 1 19 4 M 13 months WT and NS NA 13 Unilateral cryptorchidism and micropenis 60 HD 6 33 5 M 21 days NS WT1 exon 9 (394A>G) 16 Bilateral cryptorchidism [academic.oup.com]

Patient 1 was a boy with complete DDS who was presented with progressive nephropathy, unilateral Wilms' tumor, bilateral cryptorchidism, and renal histology showing diffuse [ncbi.nlm.nih.gov]

[…] pseudohermaphroditism is typical, the clinical variability of the external genitalia ranges from bifid scrotum with micropenis and palpable gonads to penoscrotal hypospadias with cryptorchidism [accessanesthesiology.mhmedical.com]

Ambiguous Genitalia

[…] lissencephaly are males who presented with a posterior-to-anterior gradient, moderately increased thickness of the brain cortex, agenesis of corpus callosum, micropenis, and cryptorchidism [ncbi.nlm.nih.gov]

Here, we report the case of a 3-year-old boy with ambiguous genitalia, bilateral cryptorchidism, and with an inguinal hernia. [ncbi.nlm.nih.gov]

Environmental endocrine disruptors have been implicated in the dramatic rise in neonatal ambiguous genitalia with variable rates of severity, such as micropenis, cryptorchidism [ncbi.nlm.nih.gov]

CHARGE Syndrome

[…] known to have CHARGE syndrome with multiple congenital anomalies, including coloboma, ventricular septal defect, choanal atresia, growth and mental retardation, bilateral cryptorchidism [ncbi.nlm.nih.gov]

The patient showed several phenotypic features of the syndrome, associated with a prepubertal state and cryptorchidism; hypogonadotrophic hypogonadism with undetectable testosterone [ncbi.nlm.nih.gov]

[…] displacement of the facial nerve (FN) toward the promontory; five patients showed delayed development; four of these children had cardiovascular malformations; three patients had cryptorchidism [ncbi.nlm.nih.gov]

Prader-Willi Syndrome

Here we report a case of Prader-Willi syndrome, who presented at 16 years of age with diabetes mellitus and cryptorchidism. [ncbi.nlm.nih.gov]

Features included cryptorchidism in 94% males, preterm birth (26%), birthweight 28 days: 1-12 months in seven; and 3.75-10.5 years in five. [ncbi.nlm.nih.gov]

[…] infantile hypotonia, a poor suck and feeding difficulties, tantrums, skin picking, compulsions, small hands and feet, and food seeking, but not hypopigmentation, a micropenis, cryptorchidism [ncbi.nlm.nih.gov]

Oculocerebrorenal Syndrome

[…] patients, short stature, mucocutaneous anomalies (eruptive vellus hair cysts, tricoepithiloma, excess skin folds and eruption cysts in oral cavity), dental malformations, cryptorchidism [orpha.net]

Russell-Silver Syndrome

[…] retardation Normal head circumference Triangular face Fifth finger clinodactyly Normal psychomotor development Supportive criteria Short arm length Limb length asymmetry Cryptorchidism [en.wikibooks.org]

In the series by Alvarenga et al.,29 cryptorchidism was present in 33% of their patients. [elsevier.es]

[…] the calcaneus Abnormal heel bone 0008364 Arthralgia Joint pain 0002829 Clinodactyly of the 5th finger Permanent curving of the pinkie finger 0004209 Constipation 0002019 Cryptorchidism [rarediseases.info.nih.gov]

Perineal Hypospadias

Evaluation and treatment of cryptorchidism (2014). American Urological Association. Available at https://www.auanet.org/guidelines/cryptorchidism-guideline. [emedicine.medscape.com]

Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption. Curr Urol Rep. 2008;9:137–142. doi: 10.1007/s11934-008-0025-0. [ncbi.nlm.nih.gov]

The incidence of intersexuality in children with cryptorchidism and hypospadias: stratification based on gonadal palpability and meatal position. [emedicine.medscape.com]

Laurence Moon Syndrome

[…] deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Obesity Having too much body fat 0001513 30%-79% of people have these symptoms Cryptorchidism [rarediseases.info.nih.gov]

Extremities Polydactyly Syndactyly Neurologic Mental retardation Learning disabilitites Genitourinary examination Hypogonadism Cryptorchidism Microphallus Persistent urogenital [wikidoc.org]

Follow-up examinationat the age of 7 years showed obesity, mental retardation, retinitis pigmentosa, microphallus, and cryptorchidism. [cocnet.org]

Trisomy 21

RESULTS: Cryptorchidism was observed in 27.5% of the patients (95CI 15.98-42.96). [ncbi.nlm.nih.gov]

Among the men, the frequency of hypospadias and cryptorchidism was similar to that of the general population. [dx.doi.org]

INTRODUCTION: Cryptorchidism is a common and prevalent condition in patients with Down syndrome. [ncbi.nlm.nih.gov]

Rudiger's Syndrome

[…] underdeveloped nipples, abnormal nails of the fingers and toes, extra fingers and/or toes, a clubfoot, a short penis, failure of the testicles to descent into the scrotum (cryptorchidism [rarediseases.org]

Schinzel-Giedion Syndrome

Midfacial retraction, frontal bossing, deep groove under the eyes, upturned nose, low-set ears, bilateral cryptorchidism, and generalized hypertrichosis were identified on [ncbi.nlm.nih.gov]

Hypogonadism

Leydig cells results in ↓ testosterone synthesis any dysfunction isolated to Sertoli cells/seminiferous tubules does not result in ↓ testosterone synthesis if testes are cryptorchid [step1.medbullets.com]

Other features include cryptorchidism and a hypoplastic penis and scrotum. [msdmanuals.com]

Clinical description CHH may be suspected at birth in males with micropenis (often associated with cryptorchidism), during adolescence due to the absence of puberty or during [orpha.net]

Spigelian Hernia

This paper describes a male neonate born with cryptorchidism and imperforate anus. [doi.org]

Nearly 28% of pediatric Spigelian hernias reported in the literature are associated with ipsilateral cryptorchidism. [ncbi.nlm.nih.gov]

[…] with cryptorchidism on the same side; termed as a syndromic association of the defect in the Spigelian fascia and absence of gubernaculum and inguinal canal. [apspjcaserep.com]

Testicular Disease

However, even if cryptorchidism is corrected, the risk of cancer is still higher than for men who never had cryptorchidism. [msdmanuals.com]

Men who have undescended testes ( cryptorchidism ) are at an increased risk of developing a seminoma. [britannica.com]

There have also been some instances of their implanting in dogs [2] Other testicular issues: Cryptorchidism or "undescended testicles", when the testicle does not descend [ipfs.io]

Malignant Neoplasm of the Testis

However, even if cryptorchidism is corrected, the risk of cancer is still higher than for men who never had cryptorchidism. [merckmanuals.com]

1,2 However, it is unknown whether cryptorchidism and testicular cancer have a common cause, or whether cryptorchidism is in itself a cause of testicular cancer. [nejm.org]

Cryptorchidism is best corrected surgically in childhood. Correcting cryptorchidism decreases the risk of testicular cancer. [merckmanuals.com]

Cryptorchidism

The cryptorchid testis may be palpable or nonpalpable. [unboundmedicine.com]

Cryptorchidism on both sides can rarely be a sign of an inter-sex disorder. [healthcentral.com]

Cancer and Fertility Risks in UDT Cryptorchidism carries long-term risks, and long-term screening should follow treatment. [massgeneral.org]

Testicular Seminoma

Cryptorchidism and testicular cancer. J Urol. 1980; 124: 382-387. Lisa J. Herrinton, Wei Zhao, Gail Husson: Management of Cryptorchidism and Risk of Testicular Cancer. [alliedacademies.org]

Cryptorchidism: Aspects of fertility and neoplasms. [urologyannals.com]

Risk Factors Cryptorchidism: Almost 10% of testicular tumours are found in patients with cryptorchidism (undescended testes) However, the increased risk of testicular cancer [healthengine.com.au]

Testicular Teratocarcinoma

If this were known they would treat the cause of cryptorchidism, and not be satisfied merely with trying to correct its end result. [books.google.com]

The risk is greatest in cases of bilateral cryptorchidism( 2 ) .Intra abdominal cryptorchidism has 20-40 times higher incidence of malignancy than the general population. [ispub.com]

Cryptorchidism is a risk factor for testicular cancer. [myvmc.com]

Testicular Embryonal Carcinoma and Seminoma

A case is presented of a young man with a history of bilateral cryptorchidism who presented with infertility. [ncbi.nlm.nih.gov]

Synchronous bilateral testicular tumors are rare and bilateral synchronous testicular seminoma in a patient with bilateral cryptorchidism is very rare. [ncbi.nlm.nih.gov]

Cryptorchidism is the most common congenital malformation of the male genitourinary tract. [ncbi.nlm.nih.gov]

Cystic Fibrosis

Genetic multisystem disease associated with abnormalities in salt and water transport across epithelial surfaces. Age of onset of symptoms is highly variable; implementation of newborn screening in some countries allows for early detection and treatment. A sweat test is the most conclusive test for diagnosis.[…] [bestpractice.bmj.com]

Testicular Embryonal Carcinoma

Malignant potential of the cryptorchid testis. Mayo Clin Proc. 1991;66:372–8. 7. Kogan SJ. Cryptorchidism. In: Kelalis PP, King LR, Belman AB, eds. [aafp.org]

Incidence is 2.5 to 20 times higher in patients with cryptorchidism. This excess risk is decreased or eliminated if orchiopexy is done before age 10 yr. [merckmanuals.com]

1. cryptorchidism 2. scrotal trauma 3. trauma TDS includes 1. sperm = ----- 2. testicular volume less than ----- 3. cryptorchidism 4. ------spadias 1. [quizlet.com]

Neoplasm of the Testis

The cause remains unknown, but cryptorchidism and gonadal dysgenesis are shown to be significant risk factors. [symptoma.com]

Malignant potential of the cryptorchid testis. Mayo Clin Proc. 1991;66:372–8. 7. Kogan SJ. Cryptorchidism. In: Kelalis PP, King LR, Belman AB, eds. [aafp.org]

In terms of risk factors, cryptorchidism is shown to substantially increase the risk of testicular neoplasia. [symptoma.com]

Becker Muscular Dystrophy

Home, Search, Index, Links, Pathology, Molecules, Syndromes, Muscle, NMJ, Nerve, Spinal, Ataxia, Antibody & Biopsy, Patient Info DYSTROPHINOPATHIES Dystrophinopathies: Clinical ● Dystrophin ; Chromosome Xp21.2-p21.1; Recessive Clinical syndromes: General Usually very high serum CK Genotype-Phenotype correlation DMD:[…] [neuromuscular.wustl.edu]

Familial Hypospadias

[…] history of hypospadias and cryptorchidism, respectively. [bdsp-ehesp.inist.fr]

cryptorchidism. [journals.lww.com]

[…] family history of hypospadias and cryptorchidism, respectively. [journals.lww.com]