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165 Possible Causes for Cytochrome C Oxidase Negative Fibers, Hyperbiliverdinemia

  • Limb-Girdle Muscular Dystrophy Type 1H

    Gastroparesis Diarrhea Multiple mitochondrial DNA deletions Vomiting Cytochrome C oxidase-negative muscle fibers Diffuse leukoencephalopathy Abnormality of the gastric mucosa[mendelian.co] jaundice Green monkey disease Greig cephalopolysyndactyly syndrome Greither disease GRFoma GRF tumor Grisart-Destrée syndrome Griscelli-Pruniéras syndrome Griscelli-Pruniéras[orpha.net] […] splitting Absent Achilles reflex EMG: myopathic abnormalities Increased variability in muscle fiber diameter Functional respiratory abnormality Cataract Intellectual disability[mendelian.co]

  • Chronic Progressive External Ophthalmoplegia

    No relationship was found between lactate values and the number of ragged red fibers, or cytochrome c oxidase-negative fibers of the proportion of deleted mtDNA measured in[ncbi.nlm.nih.gov] The first muscle biopsy showed red-ragged fibers and cytochrome c oxidase negative fibers as well as inflammatory cells infiltration.[ncbi.nlm.nih.gov] -negative fibers in skeletal muscle.[ncbi.nlm.nih.gov]

    Missing: Hyperbiliverdinemia
  • MERRF Syndrome

    Single-fiber PCR analysis showed that the proportion of mutant genomes was higher in cytochrome c oxidase (COX)-negative ragged red fibers (RRFs) than in COX-positive non-RRFs[ncbi.nlm.nih.gov] This last method will show the presence of cytochrome c oxidase negative muscle fibers and ragged red fibers, while genetic tests will detect mitochondrial deoxyribonucleic[symptoma.com]

    Missing: Hyperbiliverdinemia
  • Episodic Mitochondrial Myopathy - Optic Atrophy - Reversible Leukoencephalopathy

    Cytochrome c oxidase-negative fibers showed significantly higher levels of mutated mtDNA ( 75%) than Cytochrome c oxidase-positive fibers ([ncbi.nlm.nih.gov] In addition,in some mitochondrial myopathies, especially CPEO, KSS, and MERRF, the muscle contains Cytochrome C Oxidase-negative fibers .[neuropathology-web.org] Muscle investigations showed occasional ragged red fibers, 30% cytochrome c oxidase (COX)-negative fibers, and reduced activities of complex I IV in the respiratory chain.[ncbi.nlm.nih.gov]

    Missing: Hyperbiliverdinemia
  • MELAS Syndrome

    Note cytochrome c oxidase negative fibers as usually seen in mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS).[en.wikipedia.org] (b) Cytochrome c oxidase stain showing Type-1 lightly stained and Type II fibers, darker fibers, and a few fibers with abnormal collections of mitochondria (arrowhead).[en.wikipedia.org] (a) Modified Gomori trichrome stain showing several ragged red fibers (arrowhead).[en.wikipedia.org]

    Missing: Hyperbiliverdinemia
  • Neuroferritinopathy

    More cytochrome c oxidase-negative fibers are also often found in the muscle biopsies of affected individuals.[en.wikipedia.org] More cytochrome c oxidase -negative fibers are also often found in the muscle biopsies of affected individuals.[dict.eudic.net] c oxidase -negative fibers are also often found in the muscle biopsies of affected individuals. [ 8 ] Genetic testing Genetic testing can confirm a neuroferritinopathy diagnosis[research.omicsgroup.org]

    Missing: Hyperbiliverdinemia
  • Kearns-Sayre Syndrome

    The incidence of ragged-red fibers and cytochrome c oxidase-negative fibers in muscle is correlate with the amount of deleted mtDNA.[ncbi.nlm.nih.gov] In skeletal muscle, the abundance of deleted mtDNA was slightly higher in cytochrome c oxidase (COX)-negative fibers (70%) than in COX-positive fibers (64%), whereas in the[ncbi.nlm.nih.gov] The skeletal muscle biopsy demonstrated ragged red fibers, cytochrome C oxidase-negative and succinate dehydrogenase-positive fibers.[ncbi.nlm.nih.gov]

    Missing: Hyperbiliverdinemia
  • Keratitis

    Muscle pathology showed ragged-red fibers (RRF), ragged-blue fibers (RBF), or cytochrome c-oxidase (COX)-negative fibers in almost all patients.[orpha.net]

    Missing: Hyperbiliverdinemia
  • Multiple Symmetric Lipomatosis

    In a nonalcoholic woman with multiple symmetric lipomatosis (MSL), muscle histochemistry showed ragged-red fibers and cytochrome c oxidase negative fibers.[ncbi.nlm.nih.gov]

    Missing: Hyperbiliverdinemia
  • Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

    Note cytochrome c oxidase negative fibers as usually seen in mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS).[en.wikipedia.org] Thus, cytochrome c oxidasenegative ragged-red fibers are characteristic of tRNA mutations, except for the A3243G mutation in the tRNALeu(UUR) gene that is associated with[nejm.org] (b) Cytochrome c oxidase stain showing Type-1 lightly stained and Type II fibers, darker fibers, and a few fibers with abnormal collections of mitochondria (arrowhead).[en.wikipedia.org]

    Missing: Hyperbiliverdinemia

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