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719 Possible Causes for Cytopenia, Pancytopenia

  • Tuberculosis

    In case of pyrexia of unknown origin with peripheral cytopenia, the possibility of disseminated tuberculosis should be considered, particularly in endemic areas.[] Extrapulmonary tuberculosis can present with various hematological manifestations, including pancytopenia.[] He had high inflammatory markers with pancytopenia in a peripheral blood smear. His chest radiograph was unremarkable, and he had a negative Mantoux test result.[]

  • Myelodysplasia

    Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis with resultant cytopenias.[] An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[] […] manifests usually in childhood with neurologic disorder (cerebellar ataxia or atrophy) and/or hematologic disorder (marrow hypoplasia, myelodysplasia, acute myeloid leukemia, or pancytopenia[]

  • Aggressive Systemic Mastocytosis

    […] flushing, diarrhea, pain, organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia[] Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function[] Affected individuals may present with symptoms due to organopathies caused by mast cell infiltration, bone marrow failure and subsequent cytopenias, and symptoms of mast cell[]

  • Severe Aplastic Anemia

    His cytopenia and organ dysfunctions began to be gradually recovered since about 2002, following a 4-yr deferoxamine treatment.[] Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[] These cytopenias include agranulocytosis, PRCA and aplastic anemia. In fact, the overall long-term survival of patients with thymoma is poor once cytopenias occur.[]

  • Hypersplenism

    In this exploratory study EST is of value in evaluating patients with cytopenia and a positive EST argues strongly for hypersplenism.[] Pancytopenia can be limited by reducing the volume of the functional spleen.[] Cytopenia(s) (at least one of: anaemia, thrombocytopenia, leukopenia) Normal bone marrow (which should therefore be hyperplastic in compensation for the cytopenia(s)) Correction[]

  • Graft-versus-Host-Disease

    The clinical findings mainly include high fever, cytopenia, splenomegaly, phagocytosis, and proliferation of histiocytes in lymphoreticular tissue.[] All cases had diarrhea and pancytopenia, 4 out of 5 presented with erythematous skin rashes, and 2 had cytomegalovirus colitis.[] Serious side effects noted with Imbruvica include severe bleeding (hemorrhage), infections, low levels of blood cells (cytopenias), irregular heartbeat (atrial fibrillation[]

  • Paroxysmal Nocturnal Hemoglobinuria

    We retrospectively assessed the clinical characteristics of patients with paroxysmal nocturnal hemoglobinuria (PNH) according to severity of cytopenia.[] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[] In contrast, only a minor fraction of the patients who had been submitted for PNH testing because of unexplained thrombosis in the absence of cytopenia, were positive (0.4%[]

  • Aplastic Anemia

    Peripheral cytopenias are common in systemic lupus erythematosus, but bone marrow involvement is rarely reported.[] Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.[] Common manifestations of BMFS include varying degrees of peripheral blood cytopenias and, sometimes, progression to acute myelogenous leukemia.[]

  • Acquired Immunodeficiency Syndrome

    Clinical symptoms and cytopenia originating from HPS were reduced by pulse therapy of corticosteroid, antibiotics, and virucides, but recurred with dose reduction of the steroid[] He developed increasingly severe pancytopenia while on treatment with anti-retroviral drugs.[] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[]

  • Leukemia

    (T-LGL) on the other hand are considered to be less vulnerable for severe opportunistic fungal infection as their course of disease is chronic and marked by less violent cytopenia[] Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[] […] excess blasts 9983/3 Myelodysplastic syndrome with isolated del(5q) 9986/3 Myelodysplastic syndrome, unclassifiable 9989/3 Childhood myelodysplastic syndrome NS Refractory cytopenia[]

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