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719 Possible Causes for Cytopenia, Pancytopenia

  • Tuberculosis

    In case of pyrexia of unknown origin with peripheral cytopenia, the possibility of disseminated tuberculosis should be considered, particularly in endemic areas.[ncbi.nlm.nih.gov] Extrapulmonary tuberculosis can present with various hematological manifestations, including pancytopenia.[ncbi.nlm.nih.gov] He had high inflammatory markers with pancytopenia in a peripheral blood smear. His chest radiograph was unremarkable, and he had a negative Mantoux test result.[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis with resultant cytopenias.[ncbi.nlm.nih.gov] An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[ncbi.nlm.nih.gov] […] manifests usually in childhood with neurologic disorder (cerebellar ataxia or atrophy) and/or hematologic disorder (marrow hypoplasia, myelodysplasia, acute myeloid leukemia, or pancytopenia[ncbi.nlm.nih.gov]

  • Aggressive Systemic Mastocytosis

    […] flushing, diarrhea, pain, organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia[orpha.net] Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function[ncbi.nlm.nih.gov] Affected individuals may present with symptoms due to organopathies caused by mast cell infiltration, bone marrow failure and subsequent cytopenias, and symptoms of mast cell[symptoma.com]

  • Severe Aplastic Anemia

    His cytopenia and organ dysfunctions began to be gradually recovered since about 2002, following a 4-yr deferoxamine treatment.[ncbi.nlm.nih.gov] Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[ncbi.nlm.nih.gov] These cytopenias include agranulocytosis, PRCA and aplastic anemia. In fact, the overall long-term survival of patients with thymoma is poor once cytopenias occur.[kjim.org]

  • Hypersplenism

    In this exploratory study EST is of value in evaluating patients with cytopenia and a positive EST argues strongly for hypersplenism.[ncbi.nlm.nih.gov] Pancytopenia can be limited by reducing the volume of the functional spleen.[ncbi.nlm.nih.gov] Cytopenia(s) (at least one of: anaemia, thrombocytopenia, leukopenia) Normal bone marrow (which should therefore be hyperplastic in compensation for the cytopenia(s)) Correction[medicguide.blogspot.com]

  • Graft-versus-Host-Disease

    The clinical findings mainly include high fever, cytopenia, splenomegaly, phagocytosis, and proliferation of histiocytes in lymphoreticular tissue.[ncbi.nlm.nih.gov] All cases had diarrhea and pancytopenia, 4 out of 5 presented with erythematous skin rashes, and 2 had cytomegalovirus colitis.[ncbi.nlm.nih.gov] Serious side effects noted with Imbruvica include severe bleeding (hemorrhage), infections, low levels of blood cells (cytopenias), irregular heartbeat (atrial fibrillation[pharmacytimes.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    We retrospectively assessed the clinical characteristics of patients with paroxysmal nocturnal hemoglobinuria (PNH) according to severity of cytopenia.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] In contrast, only a minor fraction of the patients who had been submitted for PNH testing because of unexplained thrombosis in the absence of cytopenia, were positive (0.4%[ncbi.nlm.nih.gov]

  • Aplastic Anemia

    Peripheral cytopenias are common in systemic lupus erythematosus, but bone marrow involvement is rarely reported.[ncbi.nlm.nih.gov] Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.[ncbi.nlm.nih.gov] Common manifestations of BMFS include varying degrees of peripheral blood cytopenias and, sometimes, progression to acute myelogenous leukemia.[ncbi.nlm.nih.gov]

  • Acquired Immunodeficiency Syndrome

    Clinical symptoms and cytopenia originating from HPS were reduced by pulse therapy of corticosteroid, antibiotics, and virucides, but recurred with dose reduction of the steroid[ncbi.nlm.nih.gov] He developed increasingly severe pancytopenia while on treatment with anti-retroviral drugs.[ncbi.nlm.nih.gov] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Leukemia

    (T-LGL) on the other hand are considered to be less vulnerable for severe opportunistic fungal infection as their course of disease is chronic and marked by less violent cytopenia[ncbi.nlm.nih.gov] Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com] […] excess blasts 9983/3 Myelodysplastic syndrome with isolated del(5q) 9986/3 Myelodysplastic syndrome, unclassifiable 9989/3 Childhood myelodysplastic syndrome NS Refractory cytopenia[atlasgeneticsoncology.org]

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