Possible Causes for cytoplasmic inclusion bodies Psittacosis Contained in a phagosome, this dividing reticulate body enlarges and divides repeatedly by binary fusion, forming an enlarging cytoplasmic inclusion that can be stained with [antimicrobe.org] Phagolysosomal fusion is inhibited early, and the elementary body reorganizes into the reticulate body, which uses the host cell as an energy source. [antimicrobe.org] The enlarging and dividing reticulate body ultimately condenses back into elementary bodies, which are then released from the ruptured cell and begin the cycle anew ( 10, [antimicrobe.org] Chlamydial Conjunctivitis inclusion bodies of chlamydial conjunctivitis. [msdmanuals.com] Typical cytologic signs include basophilic cytoplasmic inclusion bodies (Fig. 4.13). [alpfmedical.info] […] should be examined microscopically and stained with Gram stain to identify bacteria and stained with Giemsa stain to identify the characteristic epithelial cell basophilic cytoplasmic [msdmanuals.com] Genetic Anomaly of Leukocytes Cytoplasmic inclusion bodies particularly in the neutrophils but also in monocytes, eosinophils, and basophils. [labmedicineblog.com] It is characterized by macro-thrombocytopenia with normal platelet function and cytoplasmic inclusion bodies in granulocytes. [elsevier.es] Neutrophil contains large, well-defined, basophilic, peripherally placed cytoplasmic inclusion body (resembling Döhle body). [labmedicineblog.com] Progressive Myoclonic Epilepsy Type 3 […] wave discharges in the electroencephalogram (EEG) basophilic cytoplasmic inclusion bodies in portions of brain, liver, and skin, as well as the duct cells of the sweat [slideshare.net] PAS positive polyglucosan intracytoplasmic inclusion body (Lafora Body) in the epithelial lining of the sweat gland ducts 3. [pubs.sciepub.com] Lafora Body Disease The characteristics of LBD include: generalized tonic–clonic seizures (GTCS), resting and action myoclonus, ataxia, dementia, polyspike and [slideshare.net] Hereditary Proximal Myopathy with Early Respiratory Failure inclusion bodies and myofibrillar disarray in skeletal or cardiac muscles ( Goebel 2011 ; Bé hin et al 2015 ). [medlink.com] […] aggregates Contain: Actin ; Desmin In type I muscle fibers Myofibrillar pathology Not typical Cytoplasmic bodies Eosinophilic inclusions Congophilic Variably contain: β amyloid [neuromuscular.wustl.edu] A characteristic finding in each sample was the presence of small round well defined myofibrillar inclusions of varying size referred to as cytoplasmic bodies. [bmcneurol.biomedcentral.com] Herpes Zoster Please log in to edit this article. Edit Synonym: shingles, zona German : Herpes zoster 1 Definition Herpes zoster is the secondary manifestation of an infection with Varicella zoster virus (VZV). After the primary infection with VZV, clinically presenting as " chickenpox ", the virus remains inactive in ganglia cells in[…] [flexikon.doccheck.com] Progressive Myoclonic Epilepsy Type 7 뇌와 피부의 조직검사에서 ceroid와 lipofuscin에 동시에 조직화학적 양성반응를 보이며 autofluorescent를 보이는 세포질봉입체 (cytoplasmic inclusion body) 을 관찰할 수 있습니다. [www.mediup.co.kr] […] wave discharges in the electroencephalogram (EEG) basophilic cytoplasmic inclusion bodies in portions of brain, liver, and skin, as well as the duct cells of the sweat [slideshare.net] PAS positive polyglucosan intracytoplasmic inclusion body (Lafora Body) in the epithelial lining of the sweat gland ducts 3. [pubs.sciepub.com] Stomatitis Eosinophilic inclusion bodies were noted in the cytoplasm of epithelial cells. [ncbi.nlm.nih.gov] Lafora Disease He was best known now for describing (in 1911) the intracytoplasmic inclusion bodies in "Lafora disease". [diki.pl] Axillary skin biopsy revealed intra-cytoplasmic inclusion bodies in apocrine glands (Figure 2). These were positive by periodic acid-Schiff (PAS) at 40 magnification. [cureus.com] One of the pathological hallmarks of LD is the presence of cytoplasmic polyglucosan inclusions, the Lafora bodies. [ncbi.nlm.nih.gov] Progressive Myoclonic Epilepsy Type 8 뇌와 피부의 조직검사에서 ceroid와 lipofuscin에 동시에 조직화학적 양성반응를 보이며 autofluorescent를 보이는 세포질봉입체 (cytoplasmic inclusion body) 을 관찰할 수 있습니다. [www.mediup.co.kr] […] wave discharges in the electroencephalogram (EEG) basophilic cytoplasmic inclusion bodies in portions of brain, liver, and skin, as well as the duct cells of the sweat [slideshare.net] PAS positive polyglucosan intracytoplasmic inclusion body (Lafora Body) in the epithelial lining of the sweat gland ducts 3. [pubs.sciepub.com] Rotavirus Infection inclusion bodies called viroplasms in a process involving the nonstructural viral proteins NSP5 and NSP2. [ncbi.nlm.nih.gov] Rotavirus replicates in the cytoplasm of infected cells in unique virus-induced cytoplasmic inclusion bodies called viroplasms (VMs), which are nucleated by two essential [ncbi.nlm.nih.gov] […] presenting a distinctive triple-layered particle architecture enclosing a segmented double-stranded RNA genome, exhibit a unique morphogenetic pathway requiring the formation of cytoplasmic [ncbi.nlm.nih.gov] Fibroma Histopathological examination of the skin lesions shows intracytoplasmic inclusion bodies. A virus called "malignant rabbit fibroma virus" has been isolated in rabbits. [medirabbit.com] Varicella As for the histology of gastric lesions, specific VZV infection signs may be observed, including eosinophilic inclusion bodies, cytoplasmic edema, and giant multinucleated [scielo.isciii.es] Kawasaki Disease Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the [ncbi.nlm.nih.gov] Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki disease. J. Infect. [doi.org] RNA-containing cytoplasmic inclusion bodies in ciliated bronchial epithelium months to years after acute Kawasaki disease. PLoS ONE 3, e1582 (2008). 18. Rowley, A. [nature.com] Orthostatic Hypotension Trans-activation response DNA protein 43 (TDP-43) immunoreactive cytoplasmic inclusions, the pathognomonic findings for ALS, were noted in the nucleus facialis, nucleus ambiguus [ncbi.nlm.nih.gov] The pathological hallmark of MSA is oligodendroglial cytoplasmic inclusions (Papp-Lantos bodies) that contain aggregates of misfolded alpha-synuclein (39). [onlinejacc.org] In addition, Lewy bodies and Lewy neurites were found in the brainstem and in the nucleus intermediolateralis of the thoracic cord. [ncbi.nlm.nih.gov] COVID-19 Extracellular free virus particles and inclusion bodies filled with virus particles in membrane-bound vesicles in cytoplasm were found in the human airway epithelial ultrathin [nejm.org] Toxoplasmosis Sporozoites are structurally similar to tachyzoites and bradyzoites, differing only in certain organelles and inclusion bodies ( Dubey et al., 1998a ). Figure 4. [waterpathogens.org] A- light micrography of an unsporulated oocyst showing a single cytoplasmic mass B-Fluorescent image of a sporulated oocyst with two sporocysts, it is not possible to visualize [waterpathogens.org] Foreign Body in the Eye inclusion bodies. [healio.com] Visible were intracytoplasmic inclusion bodies in the stratum spinosum (Henderson-Paterson bodies) that usually increase in size as the cells move toward the surface and crowd [healio.com] […] and eosin stain of the right upper eyelid lesion showed a crater-shaped nodular lesion with hypertrophied lobules of epidermis penetrating into the underlying dermis with intracytoplasmic [healio.com] Bladder Malakoplakia inclusion bodies (high-power view – PAS, 400) Click here to view Figure 5: Low power view 10 Prussian blue – deposits of iron within the cells Click here to view A diagnosis [ijdvl.com] Von Hansemann first described it in a necropsy study in 1903. [6] when he found a macrophagic infiltrate with PAS positive intracytoplasmic inclusion bodies in the urinary [jemds.com] Diagnostic feature is the presence of intracytoplasmic round concentric basophilic inclusions (Michaelis-Guttman bodies). [auanet.org] Alzheimer Disease A, Proximal to the nucleus ( N ) (and distal to the amyloid core), the neuron displayed, in addition to RER and elliptical inclusion bodies ( 1 ), a prominent Golgi apparatus [doi.org] B, Distal to the cell nucleus (and proximal to the amyloid core), the cytoplasm of the neuronal process displayed the presence of compact electrodense organelles surrounded [doi.org] Conjunctivitis inclusion bodies of chlamydial conjunctivitis (see Adult Inclusion Conjunctivitis ). [web.archive.org] […] should be examined microscopically and stained with Gram stain to identify bacteria and stained with Giemsa stain to identify the characteristic epithelial cell basophilic cytoplasmic [web.archive.org] Pneumonia Extracellular free virus particles and inclusion bodies filled with virus particles in membrane-bound vesicles in cytoplasm were found in the human airway epithelial ultrathin [nejm.org] Measles inclusion bodies in neurons and glial cells), (3) detection of elevated levels of measles antibody in cerebrospinal fluid, and (4) identification of measles virus RNA or [academic.oup.com] In subacute sclerosing panencephalitis (SSPE), there may be degeneration of the cortex and white matter with intranuclear and intracytoplasmic inclusion bodies 21. [slideshare.net] […] characteristic of SSPE, (2) the presence of typical histopathologic changes in neurologic tissues derived at autopsy or from brain biopsy specimens (in particular, intranuclear and cytoplasmic [academic.oup.com] Contagious Ecthyma In addition to microscopic features of contagious ecthyma in this study, eosinophilic cytoplasmic inclusion bodies are present in keratinocytes, but are transitory. [scialert.net] […] eosinophilic inclusion bodies. [histopathology-india.net] A 5-mm punch biopsy showed partial cytoplasmic vacuolisation and several cells with eosinophilic intranuclear and intracytoplasmic inclusion bodies in the stratum spinosum [ijdvl.com] Heart Failure bodies and curvilinear bodies in the cytoplasm. [doi.org] […] pathological metabolic products such as phospholipid and glycogen. 279, 280 On histology, these appear as granulovacular cell mutations and ultrastructurally as lamellar membranous inclusion [doi.org] Congestive Heart Failure bodies and curvilinear bodies in the cytoplasm. [doi.org] […] pathological metabolic products such as phospholipid and glycogen. 279, 280 On histology, these appear as granulovacular cell mutations and ultrastructurally as lamellar membranous inclusion [doi.org] Intestinal Pseudo-Obstruction Sections from these segments showed eosinophilic periodic acid Schiff stain and desmin positive cytoplasmic inclusion bodies in the myocytes. [ncbi.nlm.nih.gov] Varicella Zoster Virus Encephalitis Abstract Nine immunocompetent patients with acute herpes zoster encephalitis (HZE) were studied with the help of neurological investigations. All patients were treated with acyclovir. Neuropsychological performance was compared with that of a group of 16 healthy controls. Computed tomography of the head showed[…] [ncbi.nlm.nih.gov] Gonococcal Conjunctivitis inclusion bodies of chlamydial conjunctivitis (see Adult Inclusion Conjunctivitis ). [merckmanuals.com] Giemsa stain: helpful to identify epithelial cell basophilic cytoplasmic inclusion bodies of chlamydial conjunctivitis (adult inclusion conjunctivitis, usually chronic unilateral [hopkinsguides.com] […] should be examined microscopically and stained with Gram stain to identify bacteria and stained with Giemsa stain to identify the characteristic epithelial cell basophilic cytoplasmic [merckmanuals.com] Hemolytic Anemia The oxidized and denatured hemoglobin cross-links and precipitates intracellularly, forming inclusions that are identified as Heinz bodies on the supravital stain of the peripheral [aafp.org] Heinz bodies are removed in the spleen, leaving erythrocytes with a missing section of cytoplasm; these “bite cells” can be seen on the routine blood smear. [aafp.org]
