Cytoplasmic Inclusion Bodies: Causes & Reasons

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Possible Causes for Cytoplasmic Inclusion Bodies

Psittacosis

Contained in a phagosome, this dividing reticulate body enlarges and divides repeatedly by binary fusion, forming an enlarging cytoplasmic inclusion that can be stained with [antimicrobe.org]

Phagolysosomal fusion is inhibited early, and the elementary body reorganizes into the reticulate body, which uses the host cell as an energy source. [antimicrobe.org]

The enlarging and dividing reticulate body ultimately condenses back into elementary bodies, which are then released from the ruptured cell and begin the cycle anew ( 10, [antimicrobe.org]

X-Linked Reducing-Body Myopathy 1A

Definition A rare myopathy clinically characterized by rapidly progressive muscular weakness, and pathologically by the presence of intracytoplasmic inclusion bodies strongly [uniprot.org]

[…] reduce nitro-blue tetrazolium (hence the name `reducing body myopathy') and are located in the cytoplasm, usually close to the degenerating nucleus. [orpha.net]

[…] highly variable (EMG reveals mixed myogenic patterns), diagnosis relies on recognition of the typical histopathological findings at muscle biopsy : the non-membrane-bound inclusions [rarediseases.info.nih.gov]

Chlamydial Conjunctivitis

inclusion bodies of chlamydial conjunctivitis. [msdmanuals.com]

Typical cytologic signs include basophilic cytoplasmic inclusion bodies (Fig. 4.13). [alpfmedical.info]

[…] should be examined microscopically and stained with Gram stain to identify bacteria and stained with Giemsa stain to identify the characteristic epithelial cell basophilic cytoplasmic [msdmanuals.com]

Hereditary Proximal Myopathy with Early Respiratory Failure

inclusion bodies and myofibrillar disarray in skeletal or cardiac muscles ( Goebel 2011 ; Bé hin et al 2015 ). [medlink.com]

[…] aggregates Contain: Actin ; Desmin In type I muscle fibers Myofibrillar pathology Not typical Cytoplasmic bodies Eosinophilic inclusions Congophilic Variably contain: β amyloid [neuromuscular.wustl.edu]

A characteristic finding in each sample was the presence of small round well defined myofibrillar inclusions of varying size referred to as cytoplasmic bodies. [bmcneurol.biomedcentral.com]

Genetic Anomaly of Leukocytes

Cytoplasmic inclusion bodies particularly in the neutrophils but also in monocytes, eosinophils, and basophils. [labmedicineblog.com]

It is characterized by macro-thrombocytopenia with normal platelet function and cytoplasmic inclusion bodies in granulocytes. [elsevier.es]

Neutrophil contains large, well-defined, basophilic, peripherally placed cytoplasmic inclusion body (resembling Döhle body). [labmedicineblog.com]

Kawasaki Disease

Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the [ncbi.nlm.nih.gov]

Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki disease. J. Infect. [doi.org]

“Searching for the cause of Kawasaki disease--cytoplasmic inclusion bodies provide new insight”. 《Nature Reviews Microbiology》 6 (5): 394–401. doi:10.1038/nrmicro1853. [ko.wikipedia.org]

Cerebellar Hemangioblastoma

A 38-year-old woman with known von Hippel-Lindau syndrome underwent In-111 pentetreotide (OctreoScan) scintigraphy to evaluate a suspected pancreatic neuroendocrine tumor. The patient had undergone surgical resection of a left adrenal pheochromocytoma and a large right cerebellar hemangioblastoma several years[…] [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 3

[…] wave discharges in the electroencephalogram (EEG)  basophilic cytoplasmic inclusion bodies in portions of brain, liver, and skin, as well as the duct cells of the sweat [slideshare.net]

PAS positive polyglucosan intracytoplasmic inclusion body (Lafora Body) in the epithelial lining of the sweat gland ducts 3. [pubs.sciepub.com]

Lafora Body Disease  The characteristics of LBD include:  generalized tonic–clonic seizures (GTCS),  resting and action myoclonus,  ataxia,  dementia,  polyspike and [slideshare.net]

Contagious Ecthyma

[…] eosinophilic inclusion bodies. [histopathology-india.net]

In addition to microscopic features of contagious ecthyma in this study, eosinophilic cytoplasmic inclusion bodies are present in keratinocytes, but are transitory. [scialert.net]

A 5-mm punch biopsy showed partial cytoplasmic vacuolisation and several cells with eosinophilic intranuclear and intracytoplasmic inclusion bodies in the stratum spinosum [ijdvl.com]

Progressive Myoclonic Epilepsy Type 7

뇌와 피부의 조직검사에서 ceroid와 lipofuscin에 동시에 조직화학적 양성반응를 보이며 autofluorescent를 보이는 세포질봉입체 (cytoplasmic inclusion body) 을 관찰할 수 있습니다. [www.mediup.co.kr]

PAS positive polyglucosan intracytoplasmic inclusion body (Lafora Body) in the epithelial lining of the sweat gland ducts 3. [pubs.sciepub.com]

Neuronal Ceroid Lipofuscinosis Type 1

(cytoplasm) of cells (inclusion bodies). [rarediseases.org]

[…] study of such tissue samples reveals abnormal accumulations of deposits (i.e., pigmented lipids [lipopigments] ceroid and lipofuscin) in membrane-bound cavities within the body [rarediseases.org]

Welander Distal Myopathy

[…] aggregates Contain: Actin; Desmin In type I muscle fibers Myofibrillar pathology Not typical Cytoplasmic bodies Eosinophilic inclusions Congophilic Variably contain: β amyloid [neuromuscular.wustl.edu]

Cytoplasmic body Vacuoles Gowers-Laing (MPD1) Dominant MYH7 14q11 1.5 to 25 years Dorsiflex: Ankle; Toe ↑ up to 3x Myopathic: Mild Vacuoles: Few Distal dystrophy + Rimmed [neuromuscular.wustl.edu]

body Dominant Autosomal 40 to 50 years Hands Normal or Slight ↑ Myofibrillary inclusions MPD3 Dominant 8p22-q11 & 12q13-q22 32 to 45 years Distal Legs & Hands Normal or Slight [neuromuscular.wustl.edu]

Progressive Myoclonic Epilepsy Type 8

PAS positive polyglucosan intracytoplasmic inclusion body (Lafora Body) in the epithelial lining of the sweat gland ducts 3. [pubs.sciepub.com]

Reducing Body Myopathy

Definition A rare myopathy clinically characterized by rapidly progressive muscular weakness, and pathologically by the presence of intracytoplasmic inclusion bodies strongly [uniprot.org]

Get Update Overview Reducing-body myopathy (RBM) is a rare myopathy characterized pathologically by the presence of intracytoplasmic inclusion bodies strongly stained by menadione-linked [diseaseinfosearch.org]

This condition is also commonly associated with rimmed vacuoles and cytoplasmic bodies. [uniprot.org]

Gonococcal Conjunctivitis

inclusion bodies of chlamydial conjunctivitis (see Adult Inclusion Conjunctivitis ). [merckmanuals.com]

[…] mucus tive culture Herpes simplex virus 5 th-7 th day ❖ Watery blepharo- Multinucleated giant of life conjunctivitis cells, cytoplasmic ❖ Corneal involve- inclusion bodies [alpfmedical.info]

Platelet-Type Bleeding Disorder 19

MYH9 -RD is characterized by congenital macrothrombocytopenia, leading to bleeding tendency, along with cytoplasmic inclusion bodies within leukocytes (Döhle-like inclusions [ncbi.nlm.nih.gov]

inclusions (Dohle bodies) * * Autosomal recessive (more common) or dominate mutations in NBEAL2 gene at 3p21 * Macrothrombocytopenia with gray platelets with * deficient [quizlet.com]

[…] symptoms Platelets lose ability to change shape for platelet aggregation Platelet aggregation studies either normal or with decreased response to epinephrine * Neutrophil cytoplasmic [quizlet.com]

Alpha-B Crystallinopathy

inclusion bodies and myofibrillar disarray in skeletal or cardiac muscles ( Goebel 2011 ; Bé hin et al 2015 ). [medlink.com]

Light microscopy: Trichrome-stained tissue shows single or multiple areas of blue-red amorphous material described as hyaline structures, cytoplasmic bodies, or inclusions [emedicine.medscape.com]

Other early reports of sporadic cases include postmortem findings of cytoplasmic bodies and myofibrillar aggregates ( Kinoshita et al 1975 ; Jerusalem et al 1979 ). [medlink.com]

Fitzsimmons-Watson-Mellor Syndrome

Key words: thrombocytopenia, macrothrombocyte, Alport syndrome INTRODUCTION May-Hegglin anomaly is a rare hereditary disease, characterized by cytoplasmic inclusion body in [documents.tips]

Cowpox

The most significant pathological feature of cowpox is the presence of two types of cytoplasmic inclusion bodies: irregular B-type inclusion bodies, and numerous large, homogenous [virus.stanford.edu]

Granulomas

CYTOPLASMIC INCLUSION BODY NAKED GRANULOMA This cytoplasmic Schaumann body (arrow) is common in sarcoidosis but is nonspecific. [meddean.luc.edu]

Cytoplasmic inclusion bodies, usually within giant cells, are a feature of some granulomas. Asteroid bodies are eosinophilic stellate bodies. [ijdpdd.com]

Several types of cytoplasmic inclusion bodies can accompany granulomatous inflammation including: laminated calcific Schaumann bodies, stellate asteroid bodies, and small [meddean.luc.edu]

Bladder Malakoplakia

inclusion bodies called “Michaelis Gutmann bodies.” [6], [7] These bodies have a “target appearance,” are PAS positive, diastase resistant, and stain positive for Von Kossa [ijdvl.com]

The histiocytes contained typical cytoplasmic inclusions known as Michaelis-Gutmann bodies, which are characteristic of malakoplakia. [webview.isho.jp]

Von Hansemann first described it in a necropsy study in 1903. [6] when he found a macrophagic infiltrate with PAS positive intracytoplasmic inclusion bodies in the urinary [jemds.com]

Infantile Neuroaxonal Dystrophy

Independent of axonal changes, a few endoneurial and Schwann cells showed cytoplasmic inclusion bodies composed of structures similar to those seen in the spheroids. [ncbi.nlm.nih.gov]

Ultrastructural examination of muscle in infantile neuroaxonal dystrophy (INAD) revealed intramuscular cytoplasmic bodies, fibrous bodies and concentric laminated bodies. [ncbi.nlm.nih.gov]

Although these intramuscular inclusions have been reported in various conditions and thus are considered to be non-specific changes, this is the first report of observing [ncbi.nlm.nih.gov]

Neuronal Intranuclear Inclusion Disease

[…] disease an idiopathic disease of female Japanese Brown cattle; characterized by an acute onset of excitability, fever, sweating, sudden death plus cytoplasmic inclusion bodies [medical-dictionary.thefreedictionary.com]

Inclusion bodies, sometimes called elementary bodies, are nuclear or cytoplasmic aggregates of stable substances, usually proteins. [en.wikipedia.org]

Global impairment of the ubiquitin–proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol. [nature.com]

Lafora Disease

Axillary skin biopsy revealed intra-cytoplasmic inclusion bodies in apocrine glands (Figure 2). These were positive by periodic acid-Schiff (PAS) at 40× magnification. [cureus.com]

He was best known now for describing (in 1911) the intracytoplasmic inclusion bodies in "Lafora disease". [diki.pl]

One of the pathological hallmarks of LD is the presence of cytoplasmic polyglucosan inclusions, the Lafora bodies. [ncbi.nlm.nih.gov]

Familial Paget Disease of Bone

There may be nuclear and cytoplasmic inclusion bodies. The development of osteoclast-induced lytic lesions is followed by a proliferation of osteoblasts. [symptoma.com]

Marinesco-Sjögren-Like Syndrome

Cultured fibroblasts contained numerous cytoplasmic inclusion bodies, similar to those identified in the brain of the whoozy mouse in five unrelated patients, three with and [onlinelibrary.wiley.com]

MYH9-Related Disorder

A giant platelet as large as erythrocyte and a cytoplasmic inclusion body in a neutrophil were observed. [journals.lww.com]

Typical large inclusion body in a neutrophil is indicated by an arrowhead. (B) Light micrograph of Wright–Giemsa-stained peripheral blood. [journals.lww.com]

Measles

inclusion bodies in neurons and glial cells), (3) detection of elevated levels of measles antibody in cerebrospinal fluid, and (4) identification of measles virus RNA or [dx.doi.org]

In subacute sclerosing panencephalitis (SSPE), there may be degeneration of the cortex and white matter with intranuclear and intracytoplasmic inclusion bodies 21. [slideshare.net]

[…] characteristic of SSPE, (2) the presence of typical histopathologic changes in neurologic tissues derived at autopsy or from brain biopsy specimens (in particular, intranuclear and cytoplasmic [dx.doi.org]

Varicella

As for the histology of gastric lesions, specific VZV infection signs may be observed, including eosinophilic inclusion bodies, cytoplasmic edema, and giant multinucleated [scielo.isciii.es]

Rabies

Characteristic cytoplasmic inclusion bodies (Negri bodies) found in many neurons aid rapid laboratory diagnosis. [medical-dictionary.thefreedictionary.com]

Cytoplasmic inclusions consistent with Negri bodies were seen in CNS tissue from all recipients. [dx.doi.org]

inclusion bodies (Negri bodies) in degenerated neurons. [medical-dictionary.thefreedictionary.com]