The only known effective interference for vinca alkaloid neurotoxicity is discontinuing treatment or decrease of the dose or frequency of drug administration.
[ncbi.nlm.nih.gov]
[…] and secologanin in the leaf epidermal vacuole by strictosidine synthase (STR1).
[pnas.org]
Although a number of antidotes, including thiamine, vitamin B 12, folinic acid, pyridoxine and neuroactive agents, have been applied, these treatments have not been obviously
[ncbi.nlm.nih.gov]