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110 Possible Causes for Darier's Sign

  • Urticaria Pigmentosa

    Darier's sign was positive. Serum triptase levels were elevated. Diagnosis of mastocytosis was confirmed by pathohistology.[ncbi.nlm.nih.gov] Widespread slate-grey patches and erythematous hyperpigmented plaques were observed with a positive Darier's sign.[ncbi.nlm.nih.gov] Based on the clinical presentation of skin lesions, presence of pruritus and positive Darier's sign, cutaneous mastocytosis was diagnosed; 24-hour pH-metry revealed an increased[ncbi.nlm.nih.gov]

  • Systemic Mastocytosis

    Darier sign How is mastocytosis diagnosed? Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign .[dermnetnz.org] sign.[aafp.org] sign .[dermnetnz.org]

  • Indolent Systemic Mastocytosis

    Darier sign How is mastocytosis diagnosed? Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign .[dermnetnz.org] It is commonly characterized by multiple hyperpigmented macular or maculopapular lesions that become urticarial when rubbed or scratched (Darier’s sign).[blogs.nejm.org] This is known as Darier's sign. It's usually possible to confirm a diagnosis by carrying out a biopsy , where a small skin sample is taken and checked for mast cells.[nhs.uk]

  • Primary Anetoderma

    Anetoderma with positive Darier's sign. Our Dermatol Online. 2017;8(1):53-55.[odermatol.com] Darier s sign might reflect abnormal mechanosensitivity of mast cells in certain skin lesions [ 9 ].[odermatol.com] Positive Darier s sign on anetodermic lesions was the only point for diagnosis which is pathognomonic for mastocytosis.[odermatol.com]

  • Dermatologic Disorder

    Up to 5% of normal patients may exhibit this sign, which is a form of physical urticaria. Darier sign refers to rapid swelling of a lesion when stroked.[msdmanuals.com] Rubbing the lesion causes the development of a wheal and erythema (Darier sign).[emedicine.medscape.com] The Darier sign of urticaria pigmentosa is characterized by urticaria and erythema upon rubbing, scratching, or stroking the affected skin.[emedicine.medscape.com]

  • Scabies

    We report a misleading case of a 5-month-old child, who presented with pruritic brown-red macules of the trunk showing a positive Darier's sign, suggestive of an urticaria[ncbi.nlm.nih.gov] sign, suggestive of urticaria pigmentosa.[ncbi.nlm.nih.gov] We report two misleading cases of young infants (10- and 12-month-old infants) who presented with pruritic brown-red lesions on their trunks and showing a positive Darier's[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    Leukemia cutis: Darier’s sign in a neonate with acute lymphoblastic leukemia. J Am Acad Dermatol 1996; 34(2): 375-78. 7. Pui CH. Acute lymphoblastic lymphoma.[pacificejournals.com]

  • Leiomyomatosis

    Pseudo-Darier's sign can be seen, and when rubbed, the leiomyoma may twitch or fasciculate, mimicking the Darier's sign of mastocytosis. Figure 1. Leiomyomas.[dermatologyadvisor.com] sign may be present.[en.wikipedia.org] […] mammillary muscle of the nipple ( genital leiomyoma ), the smooth muscle of blood vessels ( angioleiomyoma ) and the lung ( pulmonary lymphangioleiomyomatosis ). [5] A pseudo- Darier[en.wikipedia.org]

  • Congenital Smooth Muscle Hamartoma

    Congenital smooth muscle hamartoma presenting with an unusual pseudo-Darier's sign. Clinical and Experimental Dermatology , 31 (1), 148-149.[moh-it.pure.elsevier.com] The lesion is most frequent in the lumbosacral area (67% [10/15]) and a positive pseudo-Darier's sign is present in 80% (12/15) of patients.[ncbi.nlm.nih.gov] We describe a case of congenital smooth muscle hamartoma with hypertrichosis and pseudo-Darier's sign, and suggest that it is a clinicohistopathological entity distinct from[ncbi.nlm.nih.gov]

  • Angioma Serpiginosum

    However, Darier’s sign was negative. The rest of the cutaneous and systemic examination was unremarkable.[termedia.pl]

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