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113 Possible Causes for Darier's Sign

  • Urticaria Pigmentosa

    Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign [ Figure 1d ].[ncbi.nlm.nih.gov] Darier's sign was positive. Serum triptase levels were elevated. Diagnosis of mastocytosis was confirmed by pathohistology.[ncbi.nlm.nih.gov] The physician calls this Darier's sign and it points at mastocytosis.[symptoma.com]

  • Systemic Mastocytosis

    Darier sign How is mastocytosis diagnosed? Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign.[dermnetnz.org] Diagnosis Recognition of mastocytosis can be difficult, especially in patients who do not have the characteristic skin lesions and Darier's sign.[aafp.org] sign.[dermnetnz.org]

  • Benign Mastocytoma

    By the end of third month, complete subsidence of the lesion was noticed with residual hyperpigmentation, negative Darier's sign, and no signs of atrophy.[f1000research.com] When a mastocytoma is agitated, it turns red, swelling in size, and can even blister; this is known as a positive “Darier’s sign.”[aocd.org] This reaction is known as the Darier sign, and it is pathognomonic for all forms of cutaneous mastocytoma. 5 The diagnosis of cutaneous mastocytosis is confirmed with biopsy[consultant360.com]

  • Diffuse Cutaneous Mastocytosis

    In the first patient, at age 1 day the disease was recognized promptly by simple techniques such as Darier's sign and Tzanck smear.[ncbi.nlm.nih.gov] sign suggesting diffuse cutaneous mastocytosis.[ncbi.nlm.nih.gov] A crucial diagnostic hint is that rubbing of affected skin areas results in whealing (Darier's sign).[ncbi.nlm.nih.gov]

  • Mastocytosis

    The patient also complained of a long history of pruritis and diffuse skin erythema that could be elicited with just mild pressure (Darier's sign).[ncbi.nlm.nih.gov] Darier sign How is mastocytosis diagnosed? Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign.[dermnetnz.org] Darier sign became negative in 14 (82%) of 17 patients. No topical or systemic complications were observed. (7).[aad.org]

  • Telangiectasia Macularis Eruptiva Perstans

    Darier’s sign, a reaction to skin being rubbed/agitated resulting in redness and swelling, is usually absent, unlike other types of mastocytosis.[aocd.org] The Darier sign was positive in 40% of their TMEP patients and the median serum tryptase level was 24.2 ng/ml.[drwarrenrheymann.com] In addition to the biopsy, the clinical appearance of the lesions, the absence of Darier’s sign, and age of onset can all point to the diagnosis.[aocd.org]

  • Cutaneous Mastocytosis

    Thirteen (23.6%) patients had history of bulla; Darier's sign was positive in 34 of 38 patients. Itching was the most common complaint, provocated by hot weather/bath.[ncbi.nlm.nih.gov] Darier's sign was present in 94% of cases. A negative Darier's sign does not rule out mastocytosis.[ncbi.nlm.nih.gov] Darier sign and dermatographism were present. Skin biopsy confirmed the case as urticaria pigmentosa which is the most common form of cutaneous mastocytosis.[ncbi.nlm.nih.gov]

  • Indolent Systemic Mastocytosis

    Darier sign How is mastocytosis diagnosed? Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign.[dermnetnz.org] It is commonly characterized by multiple hyperpigmented macular or maculopapular lesions that become urticarial when rubbed or scratched (Darier’s sign).[blogs.nejm.org] This is known as Darier's sign. It's usually possible to confirm a diagnosis by carrying out a biopsy, where a small skin sample is taken and checked for mast cells.[nhs.uk]

  • Idiopathic Recurrent and Disabling Cutaneous Herpes

    Rubbing the lesion causes the development of a wheal and erythema (Darier sign).[emedicine.medscape.com] The Darier sign of urticaria pigmentosa is characterized by urticaria and erythema upon rubbing, scratching, or stroking the affected skin.[emedicine.medscape.com] Urticaria pigmentosa (Darier sign). Telangiectasia macularis eruptiva perstans is a rare form of mastocytosis that occurs mostly in adults.[emedicine.medscape.com]

  • Mast Cell Sarcoma

    Darier sign How is mastocytosis diagnosed? Cutaneous mastocytosis is usually diagnosed by its clinical appearance and positive Darier sign.[dermnetnz.org] When you rub or scratch them, the lesions respond with a Darier’s sign. A Darier’s sign looks like hives. It’s caused by the release of histamine from the mast cells.[healthline.com] The lesions blister when rubbed (Darier's sign) and become red, swollen and itchy. This confirms the presence of mastocytosis.[patient.info]

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