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13 Possible Causes for Dark Skin Pigmentation, Deep Palmar Creases

  • Costello Syndrome

    A 2-year-old Japanese boy presented with a 'coarse' face, curly hair and loose skin of the dorsal aspect of the hands and feet with dark pigmentation.[ncbi.nlm.nih.gov] Both patients had manifestations of Costello syndrome with thick, lax skin on the dorsal aspects of hands and feet, deep palmar and plantar creases, curly hair, hyperkeratoses[ncbi.nlm.nih.gov] palmar creases Hoarse voices Loose skin, especially on the hands/feet Hyperkeratosis (thickened skin; see photos below) Lax/loose joints Broad fingertips Nail dystrophy/dysplasia[forgottendiseases.org]

  • Papillomas in Perioral, Nasal and Anal Regions

    Nails Hair Skin Cutis laxa (especially hands and feet) Dark skin pigmentation Papillomas (perioral, nasal, and anal regions) Palmar nevi Acanthosis nigricans Loose, redundant[mnglabs.com] […] altered in color but usu. not elevated that is a characteristic feature of various diseases (as smallpox) Melanin Pigments causing darkness in skin, hair, feathers, etc.[courses.washington.edu] 1 Costello Syndrome: The Challenge of Hypoglycemia and Failure to Thrive. ( 29248509 ) Leoni C....Flex E. 2018 2 Deep Palmar and Plantar Creases in Costello Syndrome. ( 29954608[malacards.org]

  • Ring Chromosome 7

    In our case study, various dark pigmented spots over the body were observed.[slideshare.net] palmar creases * Deep plantar creases * Café au lait spots * Pigmented nevi * Nevus flammeus * Fusion of cerebral hemispheres * Agenesis of olfactory bulb * Teterotopic Purkinje[checkorphan.org] Skin lesions such as pigmented naevi, cafe -au-lait spots, and vascular lesions are common to all reported cases of r(7), with the exception of one presented by Vermeesch[slideshare.net]

  • Chondrodysplasia punctata Type Toriello

    No abnormal skin pigmentation was observed until the age of one year when a brown spot was seen on the right wrist.[dokumen.tips] Deep palmar crease Deep palm line Excessively deep creases of the palm.[rarediseases.oscar.ncsu.edu] Note deep palmar creases. entities included in their table are similar to those listed by Wulfsberg et al. [19921, Bennett et al. list Conradi Hunermann syndrome as an autosomal[documents.tips]

  • Oculocerebral Hypopigmentation Syndrome Type Cross

    The skin is pale but may have a yellowish tinge and there may be a few dark pigment spots.[wohproject.org] palmar crease Upper limb undergrowth High-frequency hearing impairment Cutis laxa Microretrognathia Abnormal facial shape Cerebral cortical atrophy Talipes Narrow chest Protruding[mendelian.co] Red reflex on transillumination of the iris and nystagmus are important clues to the diagnosis in dark-skinned people.[clinicalgate.com]

  • LEOPARD Syndrome

    Her skin showed numerous, small, dark pigmented spots (fig 1).[jmg.bmj.com] palmar and plantar creases; papillomata of the face and perianal region; diffuse hypotonia and joint laxity with ulnar deviation of the wrists and fingers; tight Achilles[rasopathiesnet.org] We describe two unrelated LS cases with a common PTPN11 mutation Y279C and with completely different clinical features including distinct changes in skin pigmentation.[ncbi.nlm.nih.gov]

  • LEOPARD Syndrome

    The color of the lentigines is not specific, but it has been observed that the color is darker in dark skinned individual.[syndromespedia.com] palmar and plantar creases, papillomata of the face and perianal region, diffuse hypotonia, joint laxity, and cardiac disease.[aafp.org] Her skin showed numerous, small, dark pigmented spots (fig 1).[jmg.bmj.com]

  • Legius Syndrome

    Her skin showed numerous, small, dark pigmented spots (fig 1).[jmg.bmj.com] palmar and plantar creases; papillomata of the face and perianal region; diffuse hypotonia and joint laxity with ulnar deviation of the wrists and fingers; tight Achilles[rasopathiesnet.org] The pigmented lesions can be smooth or raised and range in color from beige to dark brown. In light-skinned individuals, they are the color of coffee with lots of cream.[firstderm.com]

  • ABCD Syndrome

    […] hair/eye pigmentation 3, blue/green eyes]; [Skin/hair/eye pigmentation 3, light/dark/freckling skin]; Albinism, oculocutaneous, type IB AD, AR 15 There is no cure for Waardenburg[centogene.com] Features of a connective tissue abnormality are observed in many individuals with Cantú syndrome, including wrinkled or loose skin especially at birth, deep palmar and plantar[ncbi.nlm.nih.gov] Waardenburg syndrome, type 4C AD 16 TYR 606933 Waardenburg syndrome/albinism, digenic; Albinism, oculocutaneous, type IA; Melanoma, cutaneous malignant, susceptibility to, 8; [Skin[centogene.com]

  • HAIR-AN Syndrome

    The protein that pigments our hair and skin is melanin.[downsyndrometreatment.net] palmar and plantar creases; papillomata of the face and perianal region; diffuse hypotonia and joint laxity with ulnar deviation of the wrists and fingers; tight Achilles[rasopathiesnet.org] Laser therapy destroys hair by targeting the pigment (melanin) in the hair follicle and is ideally suited for dark-haired, light-skinned individuals.[obgyn.ucla.edu]

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